Tag: M.W=50-100

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Computed Properties of 105-34-0.

Elyasi, Zahra;Reza Najafi, Gholam;Safaei Ghomi, Javad;Sharif, Mahboubeh A. research published 《 Design and fabrication of novel polymerized dual nature ionic liquid as highly effective catalyst for regioselective synthesis of monospiro derivatives》, the research content is summarized as follows. In this study, a novel hyper crosslinked PIL (HCPIL) as an effective heterogeneous catalyst has been developed for regioselective synthesis of monospiro compounds For this purpose, a new polymerizable ionic liquid (1-((2-methacryloyloxy)ethyl)-3-vinylimidazolium bromide ([MEVIm]Br)) was designed and synthesized with two different natures; i.e., ionic monomer and crosslinker agent. Next, magnetic HCPIL was fabricated using copolymerization of the prepared IL with N,N-methylene bisacrylamide (MBAA) in the presence of a water soluble initiator (4,4′-azobis(4-cyanopentanoic acid)) supported on vinyl functionalized Co₃O₄ nanoparticles (NPs). The results illustrated that the polymerization of ILs and covalent binding onto the magnetic support improved the thermal stability (from 75 to 33% weight loss around 450°C), reusability, catalytic activity, and generated porous structure. Accordingly, the proposed magnetic Co₃O₄@p[MEVIm]Br composite was investigated as a heterogeneous catalyst for the ultrasound-assisted synthesis of new and known spirooxindole-2-azapyrrolizidines I (X = H, 5-Cl, 5,7-Cl₂, 5-Me, etc.; Z = O, S) and spiro-2-amino-4H-pyran-oxindoles II (Y = CN, COOMe); and it showed accelerated mass transfer owing to its great porosity, high surface area (170.0 m²/g), and abundant accessible active sites. The applied scalable catalytic protocol has integrated the rules of an ideal biol.-oriented synthesis and organic synthesis to access a spiro heterocyclic skeleton. Easy work-up, high regioselectivity, excellent yields (>90%), short reaction time (6-12 min), and green reaction media are the other advantages of the proposed synthetic method.

Computed Properties of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application of C4H5NO2.

Emami, Leila;Moezi, Leila;Amiri-Zirtol, Leila;Pirsalami, Fatemeh;Divar, Masoumeh;Solhjoo, Aida;Khabnadideh, Soghra research published 《 Anticonvulsant activity, molecular modeling and synthesis of spirooxindole-4H-pyran derivatives using a novel reusable organocatalyst》, the research content is summarized as follows. Fifteen derivatives of spirooxindole-4H-pyran (I R= Et, Bu, 3-methyl-2-butene, sec-Bu, cyclopentyl, benzyl, 3-bromobenzyl, R′= CN, COOCH₃, COOC₂H₅) were subjected to evaluate through i.v. infusion of pentylenetetrazole (PTZ)-induced epilepsy mouse models. Four doses of the compounds (20, 40, 60 and 80 mg/kg) were tested in comparison with diazepam as pos. control. The resulted revealed that compounds[I R=3-methyl-2-butene, R′=CN] and [I R=sec-Bu, R′=COOC₂H₅] were the most active compounds and indicated significant anticonvulsant activity in the PTZ test. The tested compounds were prepared via a multicomponent reaction using graphene oxide (GO) based on the 1-(2-aminoethyl) piperazine as a novel heterogeneous organocatalyst. The prepared catalyst (GO-A.P.) was characterized using some diverse microscopic and spectroscopic procedures as well. The results showed high catalytic activity of the catalyst in the synthesis of spirooxindole-4H-pyran derivatives The GO-A. P. catalyst was reusable at least for 5 times with no significant decrease in its catalytic action. In silico assessment of physicochem. activity of all compounds also were done which represented appropriate properties. Finally, mol. docking study was performed to achieve their binding affinities as γ-aminobutyric acid-A (GABA-A) receptor agonists as a plausible mechanism of their anticonvulsant action. Binding free energy values of the compounds represented strongly matched with biol. activity.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Application of C4H5NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Application of C4H5NO2.

Emmetiere, Fabien;Ratnayake, Ranjala;Schares, Henry A. M.;Jones, Katherine F. M.;Bevan-Smith, Emily;Luesch, Hendrik;Harki, Daniel A.;Grenning, Alexander J. research published 《 Function-Oriented and Modular (+/-)-cis-Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF-κB Inhibitors》, the research content is summarized as follows. Described herein is a function-oriented synthesis route and biol. evaluation of pseudoguaianolide analogs, e.g., I. The 10-step synthetic route developed retains the topol. complexity of the natural product, installs functional handles for late-stage diversification, and forges the key bioactive Michael acceptors early in the synthesis. The analogs were found to be low-micromolar Nrf2 activators and micromolar NF-κB inhibitors and dependent on the local environment of the Michael acceptor moieties.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Application of C4H5NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: Methyl 2-cyanoacetate.

Escalante, Carlos H.;Carmona-Hernandez, Fernando A.;Hernandez-Lopez, Alberto;Martinez-Mora, Eder I.;Delgado, Francisco;Tamariz, Joaquin research published 《 Cascade synthesis of indolizines and pyrrolo[1,2-a]pyrazines from 2-formyl-1-propargylpyrroles》, the research content is summarized as follows. A straightforward synthesis of indolizines I [R = H, Ph, 4-MeC₆H₄, etc.; R¹ = H, CHO, Br, etc.; R² = H, Br; X = C(CO₂Me), C(CO₂Et), C(CN), C(NO₂)] and pyrrolo[1,2-a]pyrazines I [R = H, Ph, 4-MeOC₆H₄, 3-O₂NC₆H₄; R¹ = H, Br, 4-MeOC₆H₄, 3-O₂NC₆H₄; X = N] was performed through a cascade condensation/cyclization/aromatization reaction of substituted 2-formyl-N-propargylpyrroles with active methylene compounds such as nitromethane, alkyl malonates, Me cyanoacetate and malononitrile. Under basic conditions, the reaction proceeded satisfactorily to provide the corresponding 6,7-disubstituted indolizines. The condensation of the pyrrolic analogs with ammonium acetate gave rise to pyrrolo[1,2-a]pyrazines in high yields. N-Allenyl-2-formylpyrroles behaved as more reactive substrates than 2-formyl-N-propargylpyrroles, furnishing the expected indolizines in higher yields. Hence, an allenyl-containing intermediate was probably generated as the reactive species in the reaction mechanism of some N-propargyl pyrroles prior to the cyclization reaction.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Recommanded Product: Methyl 2-cyanoacetate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Computed Properties of 105-34-0.

Ferdousian, Roghayeh;Behbahani, Farahnaz K.;Mohtat, Bita research published 《 Synthesis and characterization of Fe₃O₄@Sal@Cu as a novel, efficient and heterogeneous catalyst and its application in the synthesis of 2-amino-4H-chromenes》, the research content is summarized as follows. This research paper presents the synthesis and characterization of the magnetic nanoparticle, Fe₃O₄@Sal@Cu, [Fe₃O₄@Si-CH₂-CH₂-CH₂-NH-NH-CO-N = CH-(2-HO-C₆H₄-)@Cu] as a green and retrievable catalyst. This catalyst was characterized by FTIR, XRD, EDX and TGA analyses. In addition, the catalytic activity of this new catalyst was investigated for the synthesis of 2-amino 4H-chromenes by producing good-to-excellent yields under mild reaction conditions. The other advantages of the developed nanocatalyst are its ecofriendliness, being easy to handle, high reusability and being magnetically separable. The synthesis of some new derivatives of 2-amino-4H-chromenes in the presence of this nanocatalyst is also reported.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Computed Properties of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Formula: C4H5NO2.

Ferlenghi, Francesca;Maccioni, Paola;Mugnaini, Claudia;Brizzi, Antonella;Fara, Federica;Mostallino, Rafaela;Paola, Castelli M.;Colombo, Giancarlo;Mor, Marco;Vacondio, Federica;Corelli, Federico research published 《 The GABA_B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives》, the research content is summarized as follows. We report an in vitro phase I metabolism study on COR659 (1), a 2-acylaminothiophene derivative able to suppress alc. and chocolate self-administration in rats, likely via pos. allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor. High performance liquid chromatog. coupled to tandem and high resolution mass spectrometry was employed for the characterization of in vitro metabolism and in vivo pharmacokinetics of COR659 in rats. In vitro [35S]GTPγS binding assays on stimulated GABAB and CB1 receptors, in combination with alc. and chocolate self-administration experiments in rats, were employed to assess the pharmacol. profile of this novel set of analogs, using COR659 as reference compound Eight metabolites of COR659 were discovered in liver microsomal incubates; two of them (M1, M2) were identified by comparison with synthetic reference standards In the novel set of COR659 analogs, those bearing branched alkyl substituents on the ester group, showed an improved in vitro metabolic stability (2-4), had an in vitro GABAB PAM (2-4) and/or CB1 partial agonist/antagonist profile (2-3) and maintained the ability to reduce alc. (2-4) and/or chocolate (4) self-administration in rats. Both PK and PD data ruled out any involvement of metabolite M1 in the in vivo potency of COR659 and 4. The present results, therefore, highlight the importance to design and synthesize novel compounds endowed with the dual activity profile and devoid of metabolic liabilities.

Formula: C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. SDS of cas: 105-34-0.

Ferreira, Joao Marcos Gomes de Oliveira;da Silva, Girlyanderson Araujo;Coelho, Maisa Cavalcanti;Junior, Claudio Gabriel Lima;Vale, Juliana Alves research published 《 Quick synthesis of isatin-derived Knoevenagel adducts using only eco-friendly solvent》, the research content is summarized as follows. A variety of Knoevenagel compounds I (R¹ = H, Me, allyl, Bn; R² = H, Cl, Br, NO₂ , R³ = H, Cl; EWG = CN, COOMe, COOEt) from isatin were synthesized using an eco-friendly methodol. It was used only the binary solvent ethanol: water (3:7 volume/volume) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2-5 min and isolated yields 80-96%. When cyanoesters were used as methylene actives, the reactions were longer and the knoenevagel products were obtained in 79-92% isolated yields.

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Safety of Methyl 2-cyanoacetate.

FitzSimons, Thomas M.;Oentoro, Felicia;Shanbhag, Tej V.;Anslyn, Eric V.;Rosales, Adrianne M. research published 《 Preferential Control of Forward Reaction Kinetics in Hydrogels Crosslinked with Reversible Conjugate Additions》, the research content is summarized as follows. Mol. substitutions were used to demonstrate preferential control over the kinetic rate constants in a poly(ethylene glycol)-based hydrogel with two different reversible thia-conjugate addition reactions. A strong electron-withdrawing nitrile group on the conjugate acceptor showed a 20-fold increase in the forward rate constant over a neutral withdrawing group, whereas the reverse rate constant only increased 6-fold. Rheometry experiments demonstrated that the hydrogel plateau modulus was primarily dictated by reaction equilibrium, whereas the stress relaxation characteristics of the hydrogel were dominated by the reverse rate constant Furthermore, dynamic crosslinking allowed the hydrogel to rapidly and spontaneously self-heal. These results indicate that decoupling the kinetic rate constants of bond exchange allow systematic control over dynamic covalent hydrogel bulk properties, such as their adaptability, stress relaxation ability, and self-healing properties.

Safety of Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Reference of 105-34-0.

Cottrez, Francoise;Leblanc, Virginie;Boitel, Elodie;Groux, Herve;Alepee, Nathalie research published 《 The EyeIRR-IS assay: Development and evaluation of an in vitro assay to measure the eye irritation sub-categorization of liquid chemicals》, the research content is summarized as follows. Several alternative methods have been developed and regulatory adopted by OECD as in vitro alternatives to the Draize eye irritation assay either to detect chems. not requiring classification (No Category) or inducing serious damage to the eye (Category 1) but none are sensitive enough to identify chems. inducing reversible eye effects (category 2) which are categorised by default. Therefore, the discriminatory power of a genomic approach applied to the SkinEthic Human Corneal Epithelium (HCE) model was investigated to allow subcategorization capacity according to UN GHS classification. An algorithm based on gene expression modulation on a training (62) and a test (31 liquids) chem. set, tested neat and at 30%was evaluated in an assay called EyeIRR-IS. Its accuracy prediction to distinguish Cat1/Cat2 from No Cat was 95% with a specificity of 89% and a sensitivity of 98%. For subcategorization into the 3 GHS classes the accuracy reached 84% with 94% Cat1, 67% Cat2 and 89% No Cat correctly predicted. No Cat.1 chems. were underestimated as neg. with a majority of misclassified Cat2 over predicted as Cat 1. In conclusion, the performance of the assay suggests its added value in a defined approach for liquids to replace the Draize assay.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Reference of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Reference of 105-34-0.

de Abrantes, Paloma Gomes;Costa, Israel Ferreira;Falcao, Nathalia Kellyne da Silva Marinho;de Oliveira Ferreira, Joao Marcos Gomes;Junior, Claudio Gabriel Lima;Teotonio, Ercules Epaminondas de Sousa;Vale, Juliana Alves research published 《 The Efficient Knoevenagel Condensation Promoted by Bifunctional Heterogenized Catalyst Based Chitosan-EDTA at Room Temperature》, the research content is summarized as follows. An efficient heterogeneous catalyst-based low mol. weight chitosan (LWC) modified with EDTA groups were prepared and applied as a bifunctional heterogenized catalyst in the Knoevenagel Condensation reaction, promoting fast reactions between malononitrile and aldehydes or isatins at room temperature Chitosan-EDTA (LWC-EDTA) catalysts were characterized by Fourier transform IR spectroscopy (FT-IR), thermogravimetric anal. (TGA/DTA), powder X-ray diffraction (XRD). UV-Vis absorption spectrophotometry showed that the functionalization of chitosan with EDTA for 72 h promotes the most significant modification of the matrix surface compared to the others applied, reflecting shorter reaction times. The reactions using the LWC-EDTA-72 catalyst present excellent isolated yields (78-98%) in short reaction times (0.50-120 min) for differents Knoevenagel compounds Additionaly, the catalyst was easily recovered and reused up to six times without significant losses of its catalytic activity.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Reference of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts