Tag: M.W=200-300

Name: 2,4,5-Triphenylimidazole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Exothermic Effects in Mixtures of Low-Density Polyethylene with 90 weight% of Low-Molecular-Weight Organic Compounds after Plastic Deformation under High Pressure. Author is Zhorin, V. A.; Kiselev, M. R.; Kotenev, V. A..

Mixtures of low-d. polyethylene (Tm = 108°C, enthalpy of melting 80 J g-1) with 90 weight% indigo, lophine, bromcresol purple, spiropyran, phenol red, rhodamine, phenolphthalein, and fluorescein were subjected to plastic deformation under a pressure of 1 GPa on an anvils-type high-pressure apparatus The study of deformed mixtures was carried out by the DSC method. The thermograms of heating the mixtures showed peaks of polymer melting with enthalpies, which varied from 25 to 170 J g-1. The thermograms below the polymer temperature showed either endotherm peaks of melting of fine crystallites with maxima at 44-57°C, the enthalpies of which varied within 20-120 J g-1, or exotherm peaks of crystallization of fine crystallites with maxima at 58-67°C and enthalpies from 20 up to 45 J g-1. In the range of 81-86°C, in some mixtures, the exotherm process of cold polymer crystallization took place, the enthalpy of which varied from 75 to 290 J g-1. At temperatures above the polymer Tm in the range 115-132°C, the heating thermograms showed exotherm peaks with enthalpies from 115 to 420 J g-1, while, in the range 137-164°C, they showed endotherm peaks with enthalpies of 520-540 J g-1. Crystallization of most mixtures from the melt was described by two peaks, one of which was always at 87°C, while the other could be at 48 or 112°C. The total enthalpies of crystallization varied from 40 to 82 J g-1.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Jie; Dodd, Robert H. researched the compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate( cas:166329-43-7 ).Formula: C12H16BrNO2.They published the article 《Synthesis of 1,4-benzodiazepine-1-carbothioamides, bicyclic analogs of the TIBO-type anti-HIV agents》 about this compound( cas:166329-43-7 ) in Journal of Heterocyclic Chemistry. Keywords: TIBO analog preparation HIV virucide; benzodiazepinecarbothioamide TIBO analog preparation HIV. We’ll tell you more about this compound (cas:166329-43-7).

A series of N’-substituted 1,4-benzodiazepine-1-carbothioamides were prepared by reacting the precursor 1,4-benzodiazepine with the corresponding N-substituted isothiocyanates or with sodium thiocyanatotrifluoroacetic. Despite the structural resemblance of these mols. with the potent TIBO-type anti-HIV compound R82150, none of the compounds prepared displayed no anti-HIV activity in vitro.

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Name: 2,4,5-Triphenylimidazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Fe3O4@SiO2/Bipyridinium Nanocomposite as a Magnetic and Recyclable Heterogeneous Catalyst for the Synthesis of Highly Substituted Imidazoles Via Multi-Component Condensation Strategy. Author is Hosseini, Sara; Kiasat, Ali Reza; Farhadi, Asadollah.

A magnetically separable catalyst consisting bipyridinium supported on silica coated Fe3O4 nanoparticles was prepared Fe3O4@SiO2/bipyridinium nanocomposite (Fe3O4@SiO2/BiPy+22Cl-) was used as a recyclable heterogeneous catalyst for the synthesis of various multi-substituted imidazoles via multi-components cyclocondensation reaction of 1,2-dicarbonyl compounds, aldehydes and N-source compounds under solvent-free conditions. This catalyst afforded the imidazole derivatives as key intermediates in pharmaceutical chem. in very short reaction times. The catalyst is readily recovered by simple magnetic decantation and can be recycled several times with no significant loss of catalytic activity. However, this catalyst was characterized by FT-IR, TGA, SEM and VSM.

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Reference of (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Physics and Chemistry of Solids called Pumice-modified cellulose fiber: An environmentally benign solid state hybrid catalytic system for the synthesis of 2,4,5-triarylimidazole derivatives, Author is Maleki, Ali; Gharibi, Saideh; Valadi, Kobra; Taheri-Ledari, Reza, which mentions a compound: 484-47-9, SMILESS is C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1, Molecular C21H16N2, Formula: C21H16N2.

An instrumental hybrid catalytic system comprising cellulose fiber and volcanic pumice powder, which was applied as a suitable organic-inorganic hybrid catalyst for the synthesis of 2,4,5-triarylimidazole derivatives was developed in this study. High reaction yields (97%) were obtained in short reaction times (20 min) using this catalytic system. In phys. terms, the high porosity of pumice provided an extremely high active surface area for electronic interactions among the components. Moreover, the most distinctive properties of this catalytic system were high biodegradability, simple separation of the catalyst, and good reusability. The natural pumicewas recovered easily using an external magnet and reused with no significant decline in the catalytic activity. The structural characteristics of this efficient catalytic system were assessed using various anal. methods.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Archiv der Pharmazie (Weinheim, Germany) called A novel dipeptide-based HIV protease inhibitor containing allophenylnorstatine, Author is Abdel-Rahman, Hamdy M.; El-Koussi, Nawal A.; Alkaramany, Gamal S.; Youssef, Adel F.; Kiso, Yoshiaki, which mentions a compound: 117918-23-7, SMILESS is O=C([C@H]1N(C(OC(C)(C)C)=O)CSC1(C)C)O, Molecular C11H19NO4S, Name: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid.

Dipeptide analogs, such as I and II [P2′ = NHCMe2Ph, NHN(Me)Ph, NH2CH2C6H4-2-OMe, etc.] incorporating allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] as a transition state mimic at the scissile bond, were designed and synthesized in the hope of obtaining a novel KNI series of HIV protease inhibitors. Improved activity of most of the members of series II relative to their analogs of series I can be partially attributed to the differences in the structures of the P2 moieties. Positional isomerism in the P2′ moieties significantly affected the activity and polarity of the target.

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HPLC of Formula: 484-47-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Sulfonated graphitic carbon nitride (Sg-C3N4): highly efficient heterogeneous organo-catalyst for the condensation reactions. Author is Ghafuri, Hossein; Hanifehnejad, Peyman; Rezazadeh, Zeynab; Rashidizadeh, Afsaneh.

Graphitic carbon nitride (g-C3N4) was widely studied in the field of photocatalysis and heterogeneous catalysis, due to its high surface area and great phys. and chem. stability. Herein, the synthesis of sulfonated graphitic carbon nitride (Sg-C3N4) as an efficient solid acid catalyst was reported for the preparation of imidazoles I [R = H, OH, Cl, NO2] and quinoxalines II [R1 = H, NO2; R2 = H, OMe] under mild reaction conditions.

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Khalifeh, Reza; Naseri, Vafa; Rajabzadeh, Maryam published an article about the compound: 2,4,5-Triphenylimidazole( cas:484-47-9,SMILESS:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1 ).Application of 484-47-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:484-47-9) through the article.

The core-shell of Fe3O4@SiO2 modified by epichlorohydrin and 1-methylimidazole (Fe3O4@SiO2-EPIM), a new green recyclable nanocatalyst, was designed and prepared This nanocatalyst was characterized using Fourier-transform IR spectroscopy (FT-IR), field-emission SEM (FESEM), energy-dispersive X-ray spectroscopy (EDS), elemental mapping technique, transmission electron microscopy (TEM), X-ray diffraction (XRD) techniques, thermal gravimetric anal. (TGA), N2 adsorption-desorption by Brunauer-Emmet-Teller (BET) and vibrating sample magnetometer (VSM). The catalytic activity of Fe3O4@SiO2-EPIM was assessed for synthesis of 2-R-4,5-diphenylimidazoles (R = i-Bu, Ph, anthracen-9-yl, 2-PhCH:CH, furan-2-yl, etc.) via one-pot condensation reactions of benzil, aldehydes RCHO and ammonium acetate under the optimal reaction condition (PEG 200, 100°C, 0.02 g catalyst). This nanocatalyst displayed remarkable advantages, such as environmental friendliness, shorter reaction time, excellent yields, reusability of the catalyst and simple workup procedure.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 484-47-9, is researched, Molecular C21H16N2, about Development of novel and green NiFe2O4/geopolymer nanocatalyst based on bentonite for synthesis of imidazole heterocycles by ultrasonic irradiations, the main research direction is nickel ferrite geopolymer nanocomposite preparation thermal stability; aryl aldehyde benzil ammonium acetate geopolymer nanocomposite multicomponent cyclocondensation; diphenyl arylimidazole preparation ultrasound green chem.Name: 2,4,5-Triphenylimidazole.

In this research, according to the fabrication of geopolymer based on bentonite as a substrate and embedment of NiFe2O4 nanoparticles in the construction of this polymer, the synthesis of a new magnetic nanocomposite (NiFe2O4/geopolymer) was investigated for the first time. In order to describe its chem. and morphol. features, different analyses such as Fourier transform IR spectroscopy, field-emission SEM and transmission electron microscopy images, Brunauer-Emmet-Teller adsorption-desorption isotherm, X-ray diffraction pattern, energy-dispersive X-ray anal., thermogravimetric anal., and vibrating-sample magnetometer anal. were used. The application of this novel nanocatalyst was studied for one-pot three-component condensation reaction of substituted imidazole derivatives by accelerated ultrasonic irradiations. Compared to the other conventional catalysts which were used for the synthesis of imidazole derivatives, the green synthesis method for fabrication of this heterogeneous and magnetic nanocatalyst, its high thermal stability, being eco-friendly, noticeable efficiency and easy reusability have become privileges to be superior.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Hybrid phase ligation for efficient synthesis of histone proteins, published in 2016, which mentions a compound: 117918-23-7, mainly applied to histone protein synthesis hybrid phase ligation refolding; solid phase peptide synthesis NCL desulfurization, COA of Formula: C11H19NO4S.

We introduce a hybrid solid-solution phase ligation approach that combines the efficiency of solid phase ligation with solution phase ligation in the total synthesis of modified histone proteins. A two linker strategy allows anal. throughout work on the solid phase and maximizes yields through cleavage at an external Rink, while an internal HMBA linker allows the native carboxyl terminus for any protein sequence. We demonstrate this approach for two histone proteins: triple-acetylated H4, K5ac, K12ac, K91ac, and CENP-A-K124ac.

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