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SDS of cas: 484-47-9. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about One-Pot, Two-Step Metal and Acid-Free Synthesis of Trisubstituted Imidazole Derivatives via Oxidation of Internal Alkynes Using an Iodine/DMSO System. Author is Naidoo, Shivani; Jeena, Vineet.

Diaryl alkynes underwent oxidative cyclocondensation reactions with aryl aldehydes and cyclohexanecarboxaldehyde mediated by I2 and DMSO followed by with NH4OAc in EtOH to yield diaryl- and triarylimidazoles. Benzyl alc. and cyclohexanemethanol underwent oxidative cyclocondensation with diphenylacetylene using I2 and DMSO to yield a tri-Ph and a diphenylimidazole in 81% and 20% yields, resp. A mechanism for the reaction is suggested and potential intermediates prepared and reacted further.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Imidazo-Fused Isoindoles by Pd(II)/Ag(I)-Promoted Intramolecular Dehydrogenative Coupling, the main research direction is imidazoisoindoles preparation; benzylimidazole preparation palladium silver promoter intramol dehydrogenative coupling.Name: 2,4,5-Triphenylimidazole.

An effective Pd(II)/Ag(I)-promoted intramol. cross-dehydrogenative coupling (CDC) of substituted 1-benzylimidazoles under air provides, for the first time, a simple access to several functionalized imidazo[2,1-a]isoindoles, an interesting class of polycyclic heteroaromatic compounds The direct involvement of two unactivated carbon-hydrogen bonds, without any directing group, grants an elevated atom economy of the whole process.

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Nitrile – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 484-47-9, is researched, SMILESS is C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1, Molecular C21H16N2Journal, RSC Advances called Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C-C bond cleavage, Author is Huang, Jiangkun; Luo, Lan; Xing, Naiguo; Gu, Linghui; Li, Chen; Han, Qiao; Zheng, Shilong; He, Ling, the main research direction is aryl imidazole preparation; ketone amination oxidative bond cleavage copper catalyst; aldehyde ketone amination oxidative bond cleavage copper catalyst.Formula: C21H16N2.

A one-pot synthesis, initiated by a copper salt with inorganic (NH4)2CO3 as the nitrogen source, forms divergent aryl imidazole derivatives I [R = H, Et, thiophen-2-yl, naphthalen-1-yl, 2H-1,3-benzodioxol-5-yl, etc.; R1 = Me, Et, n-Pr, Ph; Ar = 4-bromophenyl, thiophen-2-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, etc.] and II [Ar1 = 1H-indol-3-yl, 2-phenyl-1H-indol-3-yl, 5-bromo-1H-indol-3-yl, etc.; Ar2 = Ph, 4-methylphenyl; R2 = Me, 4-methylphenyl; R3 = Me, Et] from ketones ArC(O)CH2R/Ar1C(O)CH2Ar2/R2C(O)(R3) via α-amination and oxidative C-C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives I and II and has certain versatility.

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Reference:
Nitrile – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about The dual role of ammonium acetate as reagent and catalyst in the synthesis of 2,4,5-triaryl-1H-imidazoles, the main research direction is triphenylimidazole preparation; benzaldehyde benzil ammonium acetate heterocyclization.Recommanded Product: 484-47-9.

New findings concerning synthesis of some 2,4,5-triaryl-1H-imidazoles was disclosed in the absence of any catalyst. Results indicated that by enhancing the amount of ammonium acetate, an obvious acceleration can be observed in the reaction progress. It was believed that ammonium acetate can be converted to ammonia and acetic acid during the reaction and the produced acid can catalyze the reaction progress.

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Nitrile – Wikipedia,
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Computed Properties of C21H16N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about MIL-101(Cr), an efficient heterogeneous catalyst for one pot synthesis of 2,4,5-tri substituted imidazoles under solvent free conditions. Author is Manteghi, Faranak; Zakeri, Fatemeh; Guy, Owen James; Tehrani, Zari.

A chromium-containing metal-organic framework (MOF), MIL-101 (Chromium(III) benzene-1,4-dicarboxylate), was used to catalyze the one pot, three component synthesis of some 2,4,5-trisubstituted imidazoles under solvent-free conditions. The advantages of using this heterogeneous catalyst included short reaction time, high yields, easy and quick isolation of catalyst and products, low amount of catalyst needed and that the addition of solvent, salt and additives were not needed. This catalyst was highly efficient and recovered at least 5 times with a slight loss of efficiency. The structure of the metal-organic frameworks (MOF) was confirmed by X-ray diffraction (XRD) and field emission SEM (FESEM). Fourier transform IR spectroscopy (FTIR) and proton NMR (HNMR) were performed to confirm some of the synthesized products. Exptl. data indicated that the optimum amount of catalyst was 5 mg for benzil (1 mmol), 4-chlorobenzaldehyde (1 mmol) and ammonium acetate (2.5 mmol) and the synthetic route to the various imidazoles is performed in 10 min by 95% yield, an acceptable result rivalling those of other catalysts.

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 2,4,5-Triphenylimidazole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about One-Pot Three-Component Synthesis of 2,4,5-Triaryl-1H-imidazoles in the Presence of a Molecular Sieve Supported Titanium Catalyst under Mild Basic Conditions. Author is Magyar, Agnes; Hell, Zoltan.

A series of 2,4,5-trisubstituted-imidazoles was synthesized with good to excellent yields by the one-pot condensation reaction of 1,2-dicarbonyl compounds, benzaldehydes, and ammonium acetate in the presence of 4 Å mol. sieves modified with titanium(IV) as an efficient heterogeneous catalyst. The catalyst could be recovered easily and reused without significant loss of activity.

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Indalkar, Krishna; Malge, Sanjay S.; Mali, Anil S.; Chaturbhuj, Ganesh U. researched the compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ).Quality Control of 2,4,5-Triphenylimidazole.They published the article 《Expeditious and Highly Efficient One-Pot Synthesis of Functionalized Imidazoles Catalyzed by Sulfated Polyborate》 about this compound( cas:484-47-9 ) in Organic Preparations and Procedures International. Keywords: benzil aldehyde ammonium acetate sulfated polyborate green chem; diphenylimidazole preparation; benzaldehyde amine benzil ammonium acetate sulfated polyborate green chem; triphenylimidazole preparation. We’ll tell you more about this compound (cas:484-47-9).

An efficient and eco-friendly protocol for the one-pot synthesis of 2,4,5-tri- and 1,2,4,5-tetrasubstituted imidazoles in the presence of reusable sulfated polyborate as a mild, efficient, eco-friendly and inexpensive catalyst was reported. Key features of this procedure included excellent yields, short reaction times, mild conditions, an easy workup, recyclability of the catalyst and environmentally benign conditions. Moreover, this protocol tolerated a wide variety of substituent groups on the reactants.

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Nitrile – Wikipedia,
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Product Details of 484-47-9. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Base-promoted annulation of amidoximes with alkynes: simple access to 2,4-disubstituted imidazoles.

An efficient construction of imidazole ring by Cs2CO3-promoted annulation of amidoximes RC(NH2)=NOH (R = Me, Ph, 4-methylphenyl, 4-(trifluoromethyl)phenyl, thiophen-2-yl) with terminal alkynes R1CCR2 (R1 = H, Ph, 3-methylphenyl, trimethylsilyl; R2 = H, Ph, naphthalen-2-yl, thiophen-2-yl, etc.) in DMSO has been developed. This protocol provides a simple synthetic route with high atom-utilization for the synthesis of 2,4-disubstituted imidazoles I in good yields under transition-metal-free and ligand-free conditions. Internal alkynes can also undergo the annulation to give 2,4,5-trisubstituted imidazoles I.

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C21H16N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about NiO nanocomposites/rGO as a heterogeneous catalyst for imidazole scaffolds with applications in inhibiting the DNA binding activity. Author is Kumar, Gyanendra; Mogha, Navin Kumar; Kumar, Manish; Subodh; Masram, Dhanraj T..

Herein, we report a facile approach to synthesize a new highly versatile heterogeneous catalyst by spontaneous aerial oxidation based on nickel oxide nanocomposites immobilized on surface-functionalized reduced graphene oxide sheets. NiO nanocomposite/reduced graphene oxide (rGO-NiO-NC) is a highly efficient, cost-effective, reusable, selective, and eco-friendly nano-catalyst that does not lose any activity even after five reaction cycles. Nickel loading on the rGO-NiO nanocomposite was found to be 3.3 at%, which contributes to the effective and efficient use of rGO-NiO-NCs as a nano-catalyst for the synthesis of imidazole derivatives Consequently, a series of imidazole derivatives were synthesized, catalyzed by rGO-NiO-NCs, in 60 min with high yields (86% to 96%) under green conditions. Furthermore, the present synthetic methodol. was used for the synthesis of highly aromatic imidazole derivatives (B1-B3) whose calf thymus-DNA binding affinities suggest their superior inhibition ability to displace ethidium bromide (EB), which was further confirmed by mol. docking studies. Addnl., the green chem. matrix of the synthesis reaction was found to be very close to ideal values, such as carbon efficiency (82.32%), E-factor (0.51), atom economy (77.86%), process mass intensity (1.51), and reaction mass efficiency (66.14%).

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Pervaiz, Sania; Mutahir, Sadaf; Ullah, Islam; Ashraf, Muhammad; Liu, Xiao; Tariq, Sidrah; Zhou, Bao-Jing; Khan, Muhammad Asim researched the compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ).Electric Literature of C21H16N2.They published the article 《Organocatalyzed Solvent Free and Efficient Synthesis of 2,4,5-Trisubstituted Imidazoles as Potential Acetylcholinesterase Inhibitors for Alzheimer’s Disease》 about this compound( cas:484-47-9 ) in Chemistry & Biodiversity. Keywords: Alzheimer’s diseases organocatalyst mol docking AChE inhibitor SAR; 2,4,5-trisubstituted imidazoles; Alzheimer’s disease; acetylcholinesterase; molecular docking, synthesis; organocatalyst. We’ll tell you more about this compound (cas:484-47-9).

The catalytic potential of pyridine-2-carboxlic acid has been evaluated for efficient, green and solvent free synthesis of 2,4,5-trisubstituted imidazole derivatives 3a-3m. The compounds 3a-3m were synthesized by one pot condensation reaction of substituted aromatic aldehydes, benzil, and ammonium acetate in good to excellent yields (74-96%). To explore the potential of these compounds against Alzheimer’s disease, their inhibitory activities against acetylcholinesterase (AChE) were evaluated. In this series of compounds, compound 3m, bearing one ethoxy and a hydroxy group on the Ph ring on 2,4,5-trisubstituted imidazoles, proved to be a potent AChE inhibitor (102.56±0.14). Structure-activity relationship (SAR) of these compounds was developed. Mol. dockings were carried out for the compounds 3m, 3e, 3k, 3c, 3a, 3d, 3j, and 3f in order to further investigate the binding mechanism. The inhibitor mol. was molecularly docked with acetylcholinesterase to further study its binding mechanism. The amino group of the compound 3m forms an H-bond with the oxygen atom of the residue (i. e., THR121) which has a bond length of 3.051 Å.

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