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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 484-47-9, is researched, Molecular C21H16N2, about SO3H-functionalized Zeolite-Y as an Efficient Nanocatalyst for the Synthesis of N-benzimidazole-2-aryl-4-thiazolidinones and tri-substituted Imidazoles, the main research direction is sulfonic acid functionalized zeolite Y nanocatalyst preparation surface structure; aminobenzimidazole benzaldehyde thioglicolic acid zeolite nanocatalyst cyclocondensation green chem; benzoimidazolyl phenyl thiazolidinone preparation; benzil benzaldehyde ammonium acetate sulfonic acid functionalized zeolite cyclocondensation; triphenyl imidazole preparation green chem; 1,3-thiazolidin-4-one; Sulfonated zeolite; aromatic aldehydes; heterogeneous nanocatalyst; imidazole; solid acid..Product Details of 484-47-9.

SO3H-functionalized zeolite-Y was prepared and used as a catalyst for the synthesis of 2-aryl-N-benzimidazole-4-thiazolidinones and tri-substituted imidazoles at ambient conditions. High reaction rates, elimination toxic solvent, simple exptl. procedure and reusability of the catalyst were the important features of this protocol. The SO3H-functionalized zeolite-Y was characterized by FT-IR, FESEM, EDX, XRF and BET. Different kinds of aromatic aldehydes were converted to the corresponding of products with good to excellent yields.

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Reference of 2,4,5-Triphenylimidazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about One-Pot Synthesis of Polysubstituted Imidazoles Based on Pd(OAc)2/Ce(SO4)2/Bi(NO3)3 Trimetallic Cascade of Decarboxylation/Wacker-Type Oxidation/Debus-Radziszewski Reaction.

A novel and highly efficient one-pot synthesis of polysubstituted imidazoles I (R1 = H, 2-NO2, 4-Me, etc.; R2 = H, benzyl, 4-methylphenyl, etc.) from α-hydroxyphenylacetic acids R1C6H4CH(OH)CO2H, diphenylacetylene, and amines R2NH2 has been achieved by Pd(OAc)2/Ce(SO4)2/Bi(NO3)3 trimetallic catalytic system. A series of control experiments showed that this overall reaction occurs through a one-pot cascade process combining the steps of decarboxylation of α-hydroxyphenylacetic acids, Wacker-type oxidation of diphenylacetylene, and Debus-Radziszewski annulation of aryl aldehydes and benzil generated in situ, as well as amines.

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SDS of cas: 117918-23-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles. Author is Nguyen, Jeffrey-Tri; Kato, Keiko; Hidaka, Koushi; Kumada, Henri-Obadja; Kimura, Tooru; Kiso, Yoshiaki.

The human T cell leukemia/lymphotropic virus type 1 (HTLV-I) is clin. associated with adult T cell leukemia/lymphoma, HTLV-I associated myelopathy/tropical spastic paraparesis, and a number of other chronic inflammatory diseases. To stop the replication of the virus, we developed highly potent tetrapeptidic HTLV-I protease inhibitors. In a recent X-ray crystallog. study, several of our inhibitors could not form co-crystal complexes with the protease due to their high hydrophobicity. In the current study, we designed, synthesized and evaluated the HTLV-I protease inhibition potency of compounds with hydrophilic end-capping moieties with the aim of improving pharmaceutic and pharmacokinetic properties.

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Related Products of 117918-23-7. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Effect of dipeptidomimetics on malaria parasite proliferation inhibition targeting plasmepsin. Author is Hidaka, Koushi; Kimura, Tooru; Uemura, Tsuyoshi; Ruben, Adam J.; Freire, Ernesto; Kiso, Yoshiaki.

To improve the antimalarial activity of peptidomimetic plasmepsin (Plm) inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified a methylamino compound, i.e., KNI-10283, with 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining Plm inhibitory activity and low cytotoxicity.

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Synthetic Route of C11H19NO4S. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Structure-activity and structure-metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure. Author is Mimoto, Tsutomu; Terashima, Keisuke; Nojima, Satoshi; Takaku, Haruo; Nakayama, Mitsunobu; Shintani, Makoto; Yamaoka, Takashi; Hayashi, Hideya.

A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine [Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] were designed and synthesized. From the structure-metabolism relationship of this type of HIV protease inhibitors, the compounds having para substitution of the Ph ring of Apns and/or 2,6-disubstitution of the P2′ benzylamine were found to be able to avoid the P2 phenol glucuronidation that occurs with SM-319777 (formerly named JE-2147, KNI-764); one of the main metabolic pathways of SM-319777. These new analogs, such as SM-322377, had more desirable pharmacokinetic profiles and more potent antiviral activity against not only wild type HIV-1 but also the multi-drug-resistant HIV-1 than SM-319777.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Process Safety and Environmental Protection called Thermal hazards of benzaldehyde oxime: Based on decomposition products and kinetics analysis by adiabatic calorimeter, Author is Zhao, Xiao-Qiao; Wu, Wen-Qian; Li, Hua-bo; Guo, Zi-Chao; Chen, Wang-Hua; Chen, Li-Ping, which mentions a compound: 484-47-9, SMILESS is C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1, Molecular C21H16N2, Quality Control of 2,4,5-Triphenylimidazole.

As a self-reactive substance, benzaldehyde oxime (BO) is prone to a highly exothermic runaway reaction and thermal hazard anal. and the reaction kinetics calculation of BO have great significance. In this work, the decomposition products of BO in nitrogen atm. were identified by GC-MS and HPLC techniques. The impact of the decomposition products on the decomposition behaviors of BO were analyzed by comparison of the ARC test results of pure BO and mixture of BO and decomposition products. It was found that N-benzylidene benzylamine was the intermediate decomposition product and benzoic acid, benzamide, N-benzyl benzamide, and 2,4,5-triphenylimidazole were the final products of BO. A two-step continuous autocatalytic reaction model was established to depict the decomposition process of BO. The kinetic parameters of the model were calculated by applying the nonlinear optimization method. Finally, thermal behaviors under different process temperature were predicted based on the kinetic model, and the time to maximum rate (TMRad) was predicted as 112.04°C under 24 h, and 122.19°C of 8 h, which offer crucial safety information to optimize the safety conditions of BO during usage, storage and transportation, which minimizes the industrial disasters.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 484-47-9, is researched, Molecular C21H16N2, about Room temperature ionic liquid promoted improved and rapid synthesis of highly functionalized imidazole and evaluation of their inhibitory activity against human cancer cells, the main research direction is trisubstituted imidazole green preparation antitumor human docking SAR; tetrasubstituted imidazole green preparation antitumor human docking SAR.HPLC of Formula: 484-47-9.

In this study, the use of a 1,8-diazabicyclo [5.4.0]-undec-7-en-8-ium imidazolate ionic liquid as a catalyst as well as a green solvent for the expeditious multicomponent transformation of trisubstituted imidazoles I [Ar = Ph, 4-MeOC6H4; R = n-Bu, Ph, 2-furyl, etc.] and tetrasubstituted imidazoles II [R1 = Ph, 4-ClC6H4, 2-thienyl, etc.; R2 = n-Bu, Ph, 4-FC6H4, etc.; R3 = Ph, 4-MeOC6H4] via pseudo-four- and four-component reactions with short reaction time, excellent yield and purity of products was reported. The ionic liquid was cheap, biodegradable and could be recovered and reused for more than five consecutive cycles. The advantage of this protocol for gram-scale synthesis added to its practical applicability. Selected synthesized tetra- and trisubstituted imidazole scaffolds were screened for their in vitro antiproliferative properties against the human cancer cell lines EC-109, MCF-7, HGC-27, and PC-3. Compounds I [R = 2,6-di-ClC6H3, Ar = Ph], II [R1 = 4-ClC6H4, R2 = 4-MeC6H4, R3 = Ph] and II [R1 = 4-ClC6H4, R2 = Ph, R3 = 4-MeOC6H4] showed potent cytotoxic activity against the human breast cancer cell line PC-3, MCF-7 and HGC-27, resp.

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Kumari, Mitlesh; Jain, Yachana; Yadav, Priya; Laddha, Harshita; Gupta, Ragini published the article 《Synthesis of Fe3O4-DOPA-Cu Magnetically Separable Nanocatalyst: A Versatile and Robust Catalyst for an Array of Sustainable Multicomponent Reactions under Microwave Irradiation》. Keywords: DOPA functionalized magnetite supported copper multicomponent reaction nanocatalyst microwave.They researched the compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ).Computed Properties of C21H16N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:484-47-9) here.

Herein, we are reporting a facile route to synthesize magnetically separable copper loaded L-DOPA functionalized magnetite nanoparticles (Fe3O4-DOPA-CuNPs), which are well characterized by FT-IR, PXRD, SEM, EDAX, HRTEM, XPS, TGA and VSM techniques. This single catalyst exhibits excellent catalytic activity towards (i) synthesis of DHPMs via Biginelli reaction (ii) synthesis of imidazoles (iii) synthesis of 2-amino-4H-chromenes (iv) 1,2,3-triazole derivatives by ‘Click reaction’ under microwave irradiation (MWI). Interestingly it can be easily recovered and reused for subsequent cycles for above mentioned four important multicomponent reactions without any significant decrease in its catalytic activity.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 166329-43-7, is researched, Molecular C12H16BrNO2, about Antimicrobial effects of novel siderophores linked to β-lactam antibiotics, the main research direction is antibiotic beta lactam linked siderophore preparation antimicrobial effect; monobactam linked siderophore preparation antimicrobial effect; cephalosporin linked siderophore preparation antimicrobial effect; structure activity relationship beta lactam linked siderophore antibacterial; chimeric beta lactam preparation antimicrobial effect.Safety of tert-Butyl (2-(bromomethyl)phenyl)carbamate.

As a strategy to increase the penetration of antibiotic drugs through the outer membrane of Gram-neg. pathogens, facilitated transport through siderophore receptors has been frequently exploited. Hydroxamic acids, catechols, or very close isosteres of catechols, which are mimics of naturally occurring siderophores, have been used successfully as covalently linked escorting moieties, but a much wider diversity of iron binding motifs exists. This observation, coupled to the relative lack of specificity of siderophore receptors, prompted us to initiate a program to identify novel, noncatechol siderophoric structures. We screened over 300 compounds for their ability to (1) support growth in low iron medium of a Pseudomonas aeruginosa siderophore biosynthesis deletion mutant, or (2) compete with a bactericidal siderophore-antibiotic conjugate for siderophore receptor access. From these assays we identified a set of small mols. that fulfilled one or both of these criteria. We then synthesized these compounds with functional groups suitable for attachment to both monobactam and cephalosporin core structures. Siderophore-β-lactam conjugates then were tested against a panel of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus strains. Although several of the resultant chimeric compounds had antimicrobial activity approaching that of ceftazidime, and most compounds demonstrated very potent activity against their cellular targets, only a single compound was obtained that had enhanced, siderophore-mediated antibacterial activity. Results with tonB mutants frequently showed increased rather than decreased susceptibilities, suggesting that multiple factors influenced the intracellular concentration of the drugs.

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SDS of cas: 484-47-9. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Electrical and hysteric properties of organic compound-based humidity sensor and its dualistic interactive approach to H2O molecules. Author is ur Rahman, Muneeb; Gul, Hina; ur Rahman, Zia; Zulfiqar, Syed; Khan, Rajwali; Ullah, Burhan; Ahmad, Iftikhar; Saeed, Aamer; Alamgir, Khalid; Ullah, Mateen; Fan, Jiandong.

The compound lophine, 2, 4, 5-triphenyl-1 H-imidazole, has been used to fabricate humidity sensors. The sensors were tested in different humidity environments, and at various applied frequencies. The SEM images showed inter-woven spiky needles, pores, pore-channels of diverse shapes and sizes. The H2O mols. interacted with N and NH sites in the aromatic ring of the compound and thus altered the elec. properties due to the imidazole scaffold’s electron acceptor and trifling donating nature. The conduction mechanism is based on Grotthuss hydroxide transfer and prototropic mobility. The calculated dielec. constant of the material was 1.69. In 45-95%RH limit, the device’s capacitance was increased from 11 pF to 460 pF and 7.29 pF to 18.9 pF at applied frequencies 1 kHz and 10 kHz, resp. The response/recovery time was 39/20 s, resp. The maximum hysteresis was 0.44% (at 1 kHz) and 1.09% (at 10 kHz). The R2 values (goodness of fit) 0.98 and 0.99 for chemisorbed and multi-layered physisorbed layers are close to unity and thus considered the best linear-fit. The sensors showed a strong affinity to moisture at ambient conditions with low hysteresis. Fabulous improvement in the device’s sensitivity has been noted over the reported sensitivity of devices based on ceramic materials.

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