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Related Products of 117918-23-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors. Author is Nguyen, Jeffrey-Tri; Kato, Keiko; Kumada, Henri-Obadja; Hidaka, Koushi; Kimura, Tooru; Kiso, Yoshiaki.

The human T cell lymphotropic/leukemia virus type 1 (HTLV-I) causes adult T cell lymphoma/leukemia. The virus is also responsible for chronic progressive myelopathy and several inflammatory diseases. To stop the manufacturing of new viral components, in our previous reports, we derived small tetrapeptidic HTLV-I protease inhibitors with an important amide-capping moiety at the P3 residue. In the current study, we removed the P3-cap moiety and, with great difficulty, optimized the P3 residue for HTLV-I protease inhibition potency. We discovered a very potent and small tetrapeptidic HTLV-I protease inhibitor (KNI-10774a, IC50 = 13 nM).

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Structure-activity studies of FIV and HIV protease inhibitors containing allophenylnorstatine, published in 2001-05-31, which mentions a compound: 117918-23-7, mainly applied to FIV HIV protease inhibitor allophenylnorstatine derivative preparation; structure activity FIV HIV protease inhibitor allophenylnorstatine derivative, Electric Literature of C11H19NO4S.

The interaction of P1 and P3 side chains with the combining S1 and S3 hydrophobic subsites of HIV and FIV proteases has been explored using asym. competitive inhibitors. The inhibitors evaluated contained (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid (allophenylnorstatine) as the hydroxymethylcarbonyl isostere, (R)-5,5-dimethyl-1, 3-thiazolidine-4-carbonyl as P1′, Val as P2 and P2′ residues, and a variety of amino acids at the P3 and P3′ positions. All inhibitors showed competitive inhibition of both enzymes with higher potency against the HIV protease in vitro. Within this series, VLE776 is the most effective inhibitor against FIV protease, and it contains Phe at P3, but no P3′ residue. VLE776 also exhibited potent antiviral activities against the drug-resistant HIV mutants (G48V and V82F) and the TL3-resistant HIV mutants. Explanation of the inhibition activities was described. In addition, a new strategy was described for development of bifunctional inhibitors, which combine the protease inhibitor and another enzyme inhibitor in one mol.

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Akamatsu, Masaaki published an article about the compound: 2,4,5-Triphenylimidazole( cas:484-47-9,SMILESS:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1 ).Recommanded Product: 2,4,5-Triphenylimidazole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:484-47-9) through the article.

A review. Photo-induced morphol. changes in mol. assemblies, formed by surfactants, enable controlled release of incorporated substances, which can be applied in delivery systems of drugs and active components. Here, author review structural anal. of mol. assemblies, formed by azobenzene- or lophine dimer-based surfactants and their function controls with photoirradiation Moreover, author′s current subject regarding rate and dynamics of photoinduced morphol. changes in the mol. assemblies by photoirradiation is discussed.

The article 《Analysis and applications of photo-responsive molecular assemblies》 also mentions many details about this compound(484-47-9)Recommanded Product: 2,4,5-Triphenylimidazole, you can pay attention to it, because details determine success or failure

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Name: 2,4,5-Triphenylimidazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Sulfonated Fe3O4@PVA superparamagnetic nanostructure: design, in-situ preparation, characterization and application in the synthesis of imidazoles as a highly efficient organic-inorganic Bronsted acid catalyst. Author is Maleki, Ali; Rahimi, Jamal; Valadi, Kobra.

A new approach for in-situ preparation of Fe3O4@PVA nanostructure as well as its sulfonation was investigated. Then, the functional group of the prepared nanocatalyst was characterized by Fourier transform IR (FT-IR) spectroscopy. The size and morphol. of the nanoparticles were tested by using SEM images. The presence of constructive elements in the nanocomposites was confirmed by energy dispersive X-ray (EDX) anal. To better insight, the structure and magnetic properties of the prepared nanostructure were studied by X-ray diffraction (XRD) pattern and vibrating sample magnetometer (VSM) anal. Thermal stability and weight loss for the nanostructure composition at each step of weight change were screened by thermogravimetric anal. (TGA). Finally, the prepared nanocomposite structure was confirmed by transmission electron microscope (TEM) image. Then, for the first time, Fe3O4@PVA sulfonic acid-based superparamagnetic nanocatalyst was studied for the synthesis of 2,4,5-triarylimidazoles I (R = Ph, 2,4-dichlorophenyl, 2-thienyl, etc.) via a one-pot three-component condensation reaction starting from ammonium acetate, aldehydes RCHO and benzil or benzoin. Due to high magnetic property of the catalyst, it was easily recyclable by a magnet at least for ten runs without any significant reduction in the catalytic activity.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Beilstein Journal of Organic Chemistry called The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors, Author is Roper, Kimberley A.; Lange, Heiko; Polyzos, Anastasios; Berry, Malcolm B.; Baxendale, Ian R.; Ley, Steven V., which mentions a compound: 166329-43-7, SMILESS is O=C(OC(C)(C)C)NC1=CC=CC=C1CBr, Molecular C12H16BrNO2, Related Products of 166329-43-7.

Herein, we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction of alcs., e.g., PhCH2OH and Ph(CH2)4OH, in flow-chem. processing, to generate various brominated products, e.g., PhCH2Br and Ph(CH2)4Br, with high purity and in excellent yields, and with no requirement for further off-line purification

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Hidaka, Koushi; Kimura, Tooru; Tsuchiya, Yumi; Kamiya, Mami; Ruben, Adam J.; Freire, Ernesto; Hayashi, Yoshio; Kiso, Yoshiaki published the article 《Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II》. Keywords: allophenylnorstatine tripeptidomimetic preparation inhibitor malarial aspartic protease plasmepsin; plasmepsin inhibitor allophenylnorstatine tripeptidomimetic preparation structure activity relationship; antimalarial agent allophenylnorstatine tripeptidomimetic preparation.They researched the compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid( cas:117918-23-7 ).Application In Synthesis of (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:117918-23-7) here.

Based on a highly potent allophenylnorstatine-containing inhibitor, KNI-10006, against the plasmepsins of Plasmodium falciparum, the authors synthesized a series of tripeptide-type compounds with various N-terminal moieties and evaluated their inhibitory activities against plasmepsin II (Plm II). Certain phenylacetyl derivatives exhibited extremely high affinity with Ki < 0.1 nM suggesting successful hydrophobic interactions. Compounds in my other articles are similar to this one((R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid)Application In Synthesis of (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

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COA of Formula: C21H16N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Ultrasound-assisted synthesis of NiO nanoparticles and their catalytic application for the synthesis of trisubstituted imidazoles under solvent free conditions. Author is Gajengi, Aravind L.; Chaurasia, Shivkumar; Monflier, Eric; Ponchel, Anne; Ternel, Jeremy; Bhanage, Bhalchandra M..

This protocol reported the ultrasound assisted synthesis of NiO nanoparticles(NPs) using benzylamine as a base and different types of cyclodextrins (CDs) as capping agents. The use of α-CD, β-CD or γ-CD leads to different morphologies of NiO NPs. In particular, NiO nanosheets obtained using β-CD as the capping agent. The synthesized NPs were characterized by FEG-SEM, TEM, XRD and EDS anal. They showed high catalytic activity towards synthesis of different trisubstituted imidazoles under solvent free conditions. In addition, NiO NPs could be recycled and reused consecutively up to four recycle runs without much loss of their catalytic activity.

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Recommanded Product: 484-47-9. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about CoFe2O4 as green and efficient catalyst for synthesis of multisubstituted imidazoles.

In this study, CoFe2O4 as a highly efficient and eco-friendly catalyst has been developed for three component one-pot synthesis of lophine as the representative of multisubstituted imidazoles. The present methodol. offers several advantages such as excellent yields (99%), short reaction times (10 min) and environmentally mild reaction conditions (500C). Moreover, the catalyst was separated easily by an external magnet and reused several times without significant loss of catalytic properties.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ) is researched.Category: nitriles-buliding-blocks.Gabla, Jenifer J.; Lathiya, Dharmesh R.; Revawala, Akash A.; Maheria, Kalpana C. published the article 《Propyl-SO3H functionalized SBA-15: Microwave-mediated green synthesis of biologically active multi-substituted imidazole scaffolds》 about this compound( cas:484-47-9 ) in Research on Chemical Intermediates. Keywords: SBA15 propysulfate catalyst preparation multicomponent heterocyclization catalyst; imidazole multicomponent solventless green synthesis; microwave irradiation multicomponent solventless heterocyclization mediator. Let’s learn more about this compound (cas:484-47-9).

Propylsulfonic acid functionalized Santa Barbara Amorphous-15 (SBA-15-Pr-SO3H) catalyst has been synthesized using a surface modification of mesoporous SBA-15 via the one-pot co-condensation method. The synthesized SBA-15-Pr-SO3H has been characterized by peculiar characterization techniques such as small- and wide-angle XRD, SEM-EDX, TEM, TG-DTA, acidity, FT-IR, Py-FT-IR and BET surface area anal. The catalytic activity of synthesized catalyst has been studied towards solvent-free MW irradiation for the green and rapid synthesis of multi-substituted imidazoles, [2,4,5-triphenyl-1(H)-imidazole (tri-imidazole) and 1-benzyl-2,4,5-triphenyl-1H-imidazole (tetra-imidazole)]. The SBA-15-Pr-SO3H catalyst was found to be an efficient and recyclable solid acid catalyst and this solvent-free MW protocol afforded products in good to excellent yields of both, tri and tetra imidazoles (> 95%) within shorter reaction time (3 min) at 600 W as compared to the SBA-15 and other existing protocols. The applicability of this protocol was further explored by conducting the experiments in the presence of varied solvents and substituted aldehydes to generate a library of both, tri- and tetra-imidazole scaffolds. The catalyst was found to be reusable up to several runs without loss of its catalytic activity. This report allows the rapid and scalable access to a variety of multi-substituted imidazoles using SBA-15-Pr-SO3H, as heterogeneous catalyst.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Anti-Escherichia Coli Non-Pathogenic Strain Activity Of Complex Compound Based On Copper(II) And 2,4,5-triphenyl-1h-Imidazole, published in 2021, which mentions a compound: 484-47-9, Name is 2,4,5-Triphenylimidazole, Molecular C21H16N2, Computed Properties of C21H16N2.

The complex of Copper(II) binding 2,4,5-triphenyl-1H-imidazole ligand is a new copper complex and exhibits therapeutic properties to bacteria. The present observation is focused on anti-Escherichia coli non-pathogenic strain using disk diffusion method. Copper(II)-2,4,5-triphenyl-1H-imidazole complex compound showed anti-Escherichia coli non-pathogenic strain activity with a range of inhibition zone 14.51-17.37 mm and compared with free metal Cu(II) less reactive with a range of inhibition zone 10.57-27.16 mm, but more no toxic in the Vero cells with CC50 44.74 Μg/mL.

Although many compounds look similar to this compound(484-47-9)Computed Properties of C21H16N2, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Nitrile – Wikipedia,
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