Tag: M.W=200-300

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid( cas:117918-23-7 ) is researched.Formula: C11H19NO4S.Mimoto, Tsutomu; Kato, Ryohei; Takaku, Haruo; Nojima, Satoshi; Terashima, Keisuke; Misawa, Satoru; Fukazawa, Tominaga; Ueno, Takamasa; Sato, Hideharu; Shintani, Makoto; Kiso, Yoshiaki; Hayashi, Hideya published the article 《Structure-Activity Relationship of Small-Sized HIV Protease Inhibitors Containing Allophenylnorstatine》 about this compound( cas:117918-23-7 ) in Journal of Medicinal Chemistry. Keywords: peptidomimetic HIV1 protease inhibitor allophenylnorstatine preparation MSBAR. Let’s learn more about this compound (cas:117918-23-7).

We designed and synthesized a new class of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing a unique unnatural amino acid, allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4-phenyl-butyric acid], with a hydroxymethyl-carbonyl (HMC) isostere as the active moiety. A systematic evaluation of structure-activity relationships for HIV protease inhibition, anti-HIV activities, and pharmacokinetic profiles has led to the delineation of a set of structural characteristics that appear to afford an orally available HIV protease inhibitor. Optimum structures, exemplified by (I) (JE-2147), incorporated 3-hydroxy-2-methylbenzoyl groups as the P2 ligand, (R)-5,5-dimethyl-1,3-thiazolidine-4-carbonyl (Dmt) residue at the P1′ site, and 2-methylbenzyl-carboxamide group as the P2′ ligand. The present study demonstrated that I has potent antiviral activities in vitro and exhibits good oral bioavailability and plasma pharmacokinetic profiles in two species of laboratory animals.

The article 《Structure-Activity Relationship of Small-Sized HIV Protease Inhibitors Containing Allophenylnorstatine》 also mentions many details about this compound(117918-23-7)Formula: C11H19NO4S, you can pay attention to it, because details determine success or failure

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate, is researched, Molecular C12H16BrNO2, CAS is 166329-43-7, about Inhibition of Nucleoside Transport by New Analogues of 4-Nitrobenzylthioinosine: Replacement of the Ribose Moiety by Substituted Benzyl Groups.Quality Control of tert-Butyl (2-(bromomethyl)phenyl)carbamate.

4-Nitrobenzylthioinosine (NBTI, 1) is a well-known inhibitor for the nucleoside transport protein ENT1. However, its highly polar nature is unfavorable for oral absorption and/or penetration into the CNS. In the search for compounds with lower polarity than NBTI we replaced its ribose moiety by substituted benzyl groups. Halogen, hydroxyl, (trifluoro)methyl(-oxy), nitro, and amine functionalities were among the substituents at the benzyl group. In general, substitution of the benzyl group resulted in a lower affinity for ENT1. Only 2-hydroxyl substitution showed a higher affinity. Most likely this is the result of hydrogen bonding. Substitution at the 2-position of the benzyl group with aryl groups was also addressed. Compared to parent compound carrying a 2-phenylbenzyl group, all synthesized analogs gave higher affinities. Introduction of fluoro, trifluoromethyl, methoxy, and hydroxyl groups at the Ph group clearly showed that addition to the 4-position was preferable. Despite the highly different character of a ribose and a benzyl group, Ki values in the low nanomolar range were obtained for the benzyl-substituted derivatives Compound LUF5919, and compound LUF5929, displayed the highest affinity (Ki = 39 nM for both compounds), having a polar surface area of 101 Å2 and 85 Å2, resp.

The article 《Inhibition of Nucleoside Transport by New Analogues of 4-Nitrobenzylthioinosine: Replacement of the Ribose Moiety by Substituted Benzyl Groups》 also mentions many details about this compound(166329-43-7)Quality Control of tert-Butyl (2-(bromomethyl)phenyl)carbamate, you can pay attention to it, because details determine success or failure

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 484-47-9, is researched, Molecular C21H16N2, about Triphenyl-imidazole based reversible colorimetric/fluorimetric sensing and electrochemical removal of Cu2+ ions using capacitive deionization and molecular logic gates, the main research direction is triphenyl imidazole colorimetric fluorimetric sensing copper mol logic gate; Copper; Electrochemical; Fluorescence; LMCT; Logic gate; PET, imidazole.Recommanded Product: 2,4,5-Triphenylimidazole.

A simple hydroxyl-substituted triphenyl-imidazole based receptor (HTPI) which selectively detects Cu2+ ion by colorimetric and fluorimetric methods was developed. HTPI detects the Cu2+ ions with the absorption enhancement and fluorescence quenching by the possible ligand to metal charge transfer (LMCT) and the chelation-enhanced quenching (CHEQ) approaches, resp. HTPI showed high selectivity and sensitivity for Cu2+ ions detection over other interfering and competing metal ions. Interestingly, HTPI detects Cu2+ ion (LOD) at nanomolar concentrations (19 x 10-9 M (UV-vis) & 27 x 10-9 M (fluorescence), resp.), which is lower than the permissible level of Cu2+ ion reported by World Health Organization (WHO). Furthermore, HTPI was applied to the mol. logic gate function by using chem. inputs, and Cu2+ ion was potentially removed (95%) via Capacitive Deionization technique.

The article 《Triphenyl-imidazole based reversible colorimetric/fluorimetric sensing and electrochemical removal of Cu2+ ions using capacitive deionization and molecular logic gates》 also mentions many details about this compound(484-47-9)Recommanded Product: 2,4,5-Triphenylimidazole, you can pay attention to it or contacet with the author([email protected]) to get more information.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 484-47-9, is researched, SMILESS is C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1, Molecular C21H16N2Journal, ACS Catalysis called A Bifunctional Iron Nanocomposite Catalyst for Efficient Oxidation of Alkenes to Ketones and 1,2-Diketones, Author is Song, Tao; Ma, Zhiming; Ren, Peng; Yuan, Youzhu; Xiao, Jianliang; Yang, Yong, the main research direction is reusable bifunctional iron nanocomposite catalyst preparation; alkene oxidation Meinwald rearrangement; ketone preparation green chem; diketone preparation green chem.HPLC of Formula: 484-47-9.

The fabrication of a bifunctional iron nanocomposite catalyst, in which two catalytically active sites of Fe-Nx and Fe phosphate, as oxidation and Lewis acid sites, were simultaneously integrated into a hierarchical N,P-dual doped porous carbon was reported. As a bifunctional catalyst, it exhibited high efficiency for direct oxidative cleavage of alkenes into ketones or their oxidation into 1,2-diketones with a broad substrate scope and high functional group tolerance using TBHP as the oxidant in water under mild reaction conditions. Furthermore, it could be easily recovered for successive recycling without appreciable loss of activity. Mechanistic studies disclose that the direct oxidation of alkenes proceeds via the formation of an epoxide as intermediate followed by either acid-catalyzed Meinwald rearrangement to give ketones with one carbon shorter or nucleophilic ring-opening to generate 1,2-diketones in a cascade manner. This study not only opens up a fancy pathway in the rational design of Fe-N-C catalysts but also offers a simple and efficient method for accessing industrially important ketones and 1,2-diketones from alkenes in a cost-effective and environmentally benign fashion.

The article 《A Bifunctional Iron Nanocomposite Catalyst for Efficient Oxidation of Alkenes to Ketones and 1,2-Diketones》 also mentions many details about this compound(484-47-9)HPLC of Formula: 484-47-9, you can pay attention to it, because details determine success or failure

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Nitrile – Wikipedia,
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Wakale, Vijaykumar S.; Nandal, Dattatray H. published an article about the compound: 2,4,5-Triphenylimidazole( cas:484-47-9,SMILESS:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1 ).Formula: C21H16N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:484-47-9) through the article.

Mannich bases of 2-substituted 4,5-di-Ph imidazole derivatives were synthesized. IR, 1H-NMR, mass spectra, and elemental anal., characterized the structures of all synthesized derivatives The synthesized derivatives were also evaluated for their analgesic activity using Eddy’s hot plate method and anti-inflammatory activity using formalin-induced paw edema method. Many compounds have shown promising analgesic and significant anti-inflammatory activity.

The article 《Synthesis and pharmacological evaluation of some new mannich bases of 2-substituted 4, 5-diphenyl imidazole derivatives》 also mentions many details about this compound(484-47-9)Formula: C21H16N2, you can pay attention to it, because details determine success or failure

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Nitrile – Wikipedia,
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Synthetic Route of C11H19NO4S. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Attachment of basic amino group to plasmepsin inhibitors exhibiting potent antimalarial activity. Author is Kashimoto, Keisuke; Hidaka, Koushi; Uemura, Tsuyoshi; Miura, Takuya; Freire, Ernesto; Kimura, Tooru; Kiso, Yoshiaki.

Plasmepsin (Plm) is a target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. So, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, amino-substituted compound such as KNI-10538 exhibited enhanced antimalarial activity maintaining potent Plm II inhibitory activity. These results suggest that auxiliary substituents of specific basic group contribute to deliver the inhibitors to the target Plm. We further synthesized the alkylamino derivatives

After consulting a lot of data, we found that this compound(117918-23-7)Synthetic Route of C11H19NO4S can be used in many types of reactions. And in most cases, this compound has more advantages.

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 2,4,5-Triphenylimidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Iron-Phosphonate Nanomaterial: As a Novel and Efficient Organic-Inorganic Hybrid Catalyst for Solvent-Free Synthesis of Tri-Substituted Imidazole Derivatives. Author is Arpanahi, Foozhan; Mombeni Goodajdar, Bijan.

In this study, organic-metal nanocatalyst was synthesized by reacting ferric(II) chloride with organic phosphonate ligand. The particle size was controlled with the help of the surfactant. Nanoparticle structure was analyzed using Fourier transform IR, thermogravimetric anal., vibrating sample magnetometer, SEM, dispersive X-ray, Brunauer-Emmett-Teller isotherm and X-ray diffraction spectra. Next, its catalytic activity was investigated in the synthesis of heterocyclic compounds (2,4,5-trisubstituted imidazoles derivatives). Under optimal conditions, the products were obtained with good efficiency and short time. Products identification were evaluated using phys. data, FT-IR, 1H and 13C NMR anal. The results show that the new method, namely the use of iron-phosphonate nanostructures, is effective for the synthesis of trisubstituted imidazole derivatives This method has many advantages such as short reaction time, high yield, solvent free conditions, recyclability of the catalyst, and easy workup.

After consulting a lot of data, we found that this compound(484-47-9)Recommanded Product: 2,4,5-Triphenylimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Allophenylnorstatine-containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 ligands, published in 2005-06-30, which mentions a compound: 117918-23-7, Name is (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, Molecular C11H19NO4S, Name: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid.

The design and development of potent HIV protease inhibitors remain an attractive target for antiviral therapy. A novel class of HIV protease inhibitors containing allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4 phenylbutyric acid] as a transition state mimic have been reported. In this work we fixed P2′ (as tert-butylamino or 2-methylbenzylamino) and changed P2 moiety to provide two series of dipeptide analogs. Preliminary evaluation of the activity of the synthesized derivatives were determined as percentage of enzyme inhibition at 5 μM level. The results showed that the introduction of 2-methylbenzylamino moiety as P2′ ligands considerably improved HIV inhibitory activity in comparison with the tert-Bu amino analogs. It was found that compounds in both series retained activity still less than the lead compounds KNI-577 and KNI-727.

After consulting a lot of data, we found that this compound(117918-23-7)Name: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Heravi, Majid Momahed; Karimi, Narges; Pooremami, Samira published an article about the compound: 2,4,5-Triphenylimidazole( cas:484-47-9,SMILESS:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1 ).Formula: C21H16N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:484-47-9) through the article.

We introduced a very simple, one-pot three component procedure for preparation of 2,4,5-triaryl-imidazoles from the reaction of benzyl, aldehydes and ammonium acetate, as ammonia source, catalyzed by Caro’s acid-silica gel under Solvent -free condition.

After consulting a lot of data, we found that this compound(484-47-9)Formula: C21H16N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 484-47-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Magnetic nano cobalt ferrite: an efficient recoverable catalyst for synthesis of 2,4,5-trisubstituted imidazoles. Author is Gupta, Srinivasa; Lakshman, Manisha.

An efficient three-component synthesis of 2,4,5-trisubstituted imidazoles I (X = H, 4-Me, 4-F, etc.) by one pot condensation of aldehydes, diketones and ammonium acetate using CoFe2O4 magnetic nanoparticles as an efficient and environmentally benign catalyst is described. The easy recovery of the catalyst and reusability, broad substrate scopes, high yields of products and ethanol as solvent make this protocol practical, environmentally friendly and economically attractive.

After consulting a lot of data, we found that this compound(484-47-9)Application of 484-47-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts