Tag: M.W=200-300

COA of Formula: C21H16N2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions.

A TMSOTf-catalyzed synthesis of trisubstituted imidazoles through the reaction of 1,2-diketones and aldehydes using hexamethyldisilazane as a nitrogen source under microwave heating and solvent-free conditions was developed. The chem. structures of representative trisubstituted imidazoles were confirmed using X-ray single-crystal diffraction anal. This synthetic method had several advantages including the involvement of mild Lewis acid, being metal- and additive-free, wide substrate scope with good to excellent yields and short reaction time. Furthermore, the application of the methodol. was demonstrated in the synthesis of biol. active imidazole-based drugs.

《TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4,5-Triphenylimidazole)COA of Formula: C21H16N2.

Reference:
Nitrile – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid( cas:117918-23-7 ) is researched.Name: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid.Zhang, Meihui; Nguyen, Jeffrey-Tri; Kumada, Henri-Obadja; Kimura, Tooru; Cheng, Maosheng; Hayashi, Yoshio; Kiso, Yoshiaki published the article 《Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme》 about this compound( cas:117918-23-7 ) in Bioorganic & Medicinal Chemistry. Keywords: HTLVI protease inhibitor tetrapeptide preparation structure activity relationship. Let’s learn more about this compound (cas:117918-23-7).

Adult T-cell leukemia and tropical spastic paraparesis/HTLV-I-associated myelopathy are only some of the more common end results of an infection with a human T-cell leukemia virus type 1 (HTLV-I). Expanding from their previous reports, the authors have synthesized all different permutations of tetrapeptidic HTLV-I protease inhibitors using at least eight P3-cap and five P’1-cap moieties. The inhibitors exhibited over 97% inhibition against HIV-1 protease and a wide range of inhibitory activity against HTLV-I protease.

Different reactions of this compound((R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid)Name: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid require different conditions, so the reaction conditions are very important.

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Kadu, Vikas D.; Mali, Ganesh A.; Khadul, Siddheshwar P.; Kothe, Gokul J. published an article about the compound: 2,4,5-Triphenylimidazole( cas:484-47-9,SMILESS:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1 ).Formula: C21H16N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:484-47-9) through the article.

A rapid practical process was developed for synthesis of 2,4,5-trisubstituted imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope was well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.

Different reactions of this compound(2,4,5-Triphenylimidazole)Formula: C21H16N2 require different conditions, so the reaction conditions are very important.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of 2,4,5-triaryl-1H-imidazole derivatives using SiO2-NaHSO4, published in 2020, which mentions a compound: 484-47-9, Name is 2,4,5-Triphenylimidazole, Molecular C21H16N2, COA of Formula: C21H16N2.

A mixture of benzyl, aromatic aldehydes and ammonium acetate in presence of SiO2-NaHSO4 under solvent-free condition converted to 2,4,5-triaryl-1H-imidazoles. The short reaction time, cleaner reaction and easy workup make this protocol practical and economically attractive.

《Synthesis of 2,4,5-triaryl-1H-imidazole derivatives using SiO2-NaHSO4》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4,5-Triphenylimidazole)COA of Formula: C21H16N2.

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Nitriles – Chemistry LibreTexts

Computed Properties of C21H16N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Acidic Ionic Liquid [H-NP]HSO4 Promoted One-Pot Synthesis of Dihydro-1H-Indeno[1,2-b]pyridines and Polysubstituted Imidazoles. Author is Alinezhad, Heshmatollah; Tajbakhsh, Mahmoud; Maleki, Behrooz; Pourshaban Oushibi, Fereshteh.

A green and efficient protocol for the one-pot synthesis of dihydro-1H-indeno[1,2-b]pyridines and polysubstituted imidazoles using a recyclable acidic ionic liquid [H-NP]HSO4 (H-NPBS) was reported. Non-corrosiveness, safe, low waste, generality, simplicity, easy for separation, short reaction times, high yields and environmentally benign were some of the advantages of this methodol. The [H-NP]HSO4 (H-NPBS) was effectively recycled for six consecutive cycles without appreciable loss in its activity.

《Acidic Ionic Liquid [H-NP]HSO4 Promoted One-Pot Synthesis of Dihydro-1H-Indeno[1,2-b]pyridines and Polysubstituted Imidazoles》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4,5-Triphenylimidazole)Computed Properties of C21H16N2.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A new nanocomposite catalyst based on clay-supported heteropolyacid for the green synthesis of 2,4,5-trisubstituted imidazoles, published in 2020-08-31, which mentions a compound: 484-47-9, mainly applied to imidazole preparation green chem; benzil benzaldehyde heterocyclization nanocatalyst, Application of 484-47-9.

Intercalation of cetyltrimethylammonium (CTA+) cations within the nanolayers of montmorillonite (MMT) clay followed by reaction with Keggin-type phosphomolybdic acid (PMo) resulted in the synthesis of (CTA)3PMo-MMT nanocomposite catalyst. The prepared nanocomposite catalyst was characterized using different physicochem. methods such as Fourier-transform IR and inductively coupled plasma-optical emission spectroscopies, X-ray diffraction, and nitrogen adsorption-desorption (Brunauer-Emmett-Teller method) analyses. Characterization techniques demonstrated the intercalation of (CTA)3PMo species into the nanolayers of MMT. The resulting (CTA)3PMo-MMT nanocomposite catalyst efficiently catalyzed the synthesis of 2,4,5-trisubstituted imidazoles I (R = 4-chlorophenyl, 2-bromophenyl, 1-naphthyl, etc.) under solvent-free conditions. The efficiency is due to the fact that the presence of CTA+ species makes the nanocomposite catalyst hydrophobic and facilitates the accessibility of hydrophobic reactants to active sites in the course of the reaction. High activity and selectivity were achieved in the presence of the prepared nanocomposite catalyst. The nanocomposite catalyst was readily isolated from the reaction mixture using simple filtration, washed with ethanol, and recycled five times without a major loss of activity.

The article 《A new nanocomposite catalyst based on clay-supported heteropolyacid for the green synthesis of 2,4,5-trisubstituted imidazoles》 also mentions many details about this compound(484-47-9)Application of 484-47-9, you can pay attention to it, because details determine success or failure

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Nitrile – Wikipedia,
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Synthetic Route of C21H16N2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Ni-Rhodanine Complex Supported on FSM-16 as Mesoporous Silica Support: Synthesis, Characterization and Application in Synthesis of Tri and Tetrasubstituted Imidazoles and 3,4-Dihydropyrimidine-2-(1H)-Ones. Author is Gholamian, Fatemeh; Hajjami, Maryam; Sanati, Ali Mohammad.

A new, efficient and recoverable heterogeneous catalyst was successfully synthesized by functionalization of mesoporous silica FSM-16. The FSM-16/CPTMS-Rh-Ni(II) characterization with several techniques such as, XRD, TGA, FT-IR, SEM, EDX, BET and ICP. As a result, it was found that this synthesized compound acted as catalyst for many multi component reactions. These reactions included the synthesis of 2,4,5-triaryl-1H-imidazoles, 1,2,4,5-tetrasubstituted imidazoles and 3,4-dihydropyrimidine-2-(1H)-ones derivatives

The article 《Ni-Rhodanine Complex Supported on FSM-16 as Mesoporous Silica Support: Synthesis, Characterization and Application in Synthesis of Tri and Tetrasubstituted Imidazoles and 3,4-Dihydropyrimidine-2-(1H)-Ones》 also mentions many details about this compound(484-47-9)Synthetic Route of C21H16N2, you can pay attention to it, because details determine success or failure

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Hilal, D. A.; Hanoon, H. D. published the article 《Bronsted acidic ionic liquid catalyzed eco-friendly and efficient procedure for synthesis of 2,4,5-trisubstituted imidazole derivatives under ultrasound irradiation and optimal conditions》. Keywords: imidazole preparation ultrasonication green chem; Bronsted acidic imidazolium cyclohexadienone ionic liquid catalyst preparation.They researched the compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ).Application of 484-47-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:484-47-9) here.

2-[(1H-imidazol-3-ium-3-yl)methyl]-4-{bis[3-((1H-imidazol-3-ium-3-yl)methyl-4-hydroxyphenyl)]methylene}cyclohexa-2,5-dienone trihydrogen sulfate ([2-(imm)-4-{b(immh)m}c][HSO4]3), as the new Bronsted acidic ionic liquid, is effectively prepared and revealed by using FTIR, 1H NMR, SEM, EDS, XRD and mass data. Afterward, its catalytic activity was investigated for the synthesis of 2,4,5-trisubstituted imidazole derivatives via the simple reaction between different aldehydes, ammonium acetate and benzil/benzoin under ultrasound irradiation at ambient temperature and optimal conditions. The novel procedure has the advantages of high yields, easy handling, short reaction times, and being eco-friendly and economical. Moreover, the catalyst can be easily recovered for several times without any addnl. treatment.

Different reactions of this compound(2,4,5-Triphenylimidazole)Application of 484-47-9 require different conditions, so the reaction conditions are very important.

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Nitrile – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Synthesis and Structure-Activity Relationships of a Series of Penicillin-Derived HIV Proteinase Inhibitors: Heterocyclic Ring Systems Containing P1′ and P2′ Substituents.Recommanded Product: 117918-23-7.

As an extension of our earlier work based upon a single penicillin-derived thiazolidine moiety we have found that the decahydroisoquinoline grouping, also present in Ro 31-8959, is an effective replacement for one of the thiazolidine units in C2 sym. penicillin-derived dimers. Reaction of racemic epoxide I with [3S-[3α,4aα,8aα]]-decahydro-N-(1,1-dimethylethyl)-3-isoquinolinecarboxamide gave diastereoisomers (R)- and (S)-II. Reaction of the amines derived from (R)- and (S)-II with thiazolidine III gave thiazolidineacetamides (R)- and (S)-IV, resp. (S)-IV was a potent inhibitor of HIV proteinase (IC50 = 23 nM) with antiviral activity against HIV-1 in vitro (EC50 C8166 cells = 50 nM). However, a poor pharmacokinetic profile in the dog for (S)-IV and its analogs, in keeping with earlier studies on penicillin-derived dimers in three species, precluded their development as potential antivirals.

Different reactions of this compound((R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid)Recommanded Product: 117918-23-7 require different conditions, so the reaction conditions are very important.

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Nitrile – Wikipedia,
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Synthetic Route of C21H16N2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Nanomagnetic organic-inorganic hybrid (CuFe2O4@Si-Imid-PMo): an efficient green catalyst for the synthesis of 2,4,5-trisubstituted imidazoles.

In this research, a new magnetic nanocatalyst CuFe2O4@Si-Imid-PMo containing acidic ionic liquid based on imidazolium cation and phosphomolybdic acid anion immobilized on CuFe2O4@SiO2 magnetic nanoparticles was prepared and characterized using FT-IR, EDX, SEM, and VSM techniques. Then, the catalytic activity of CuFe2O4@Si-Imid-PMo was evaluated in the synthesis of 2,4,5-trisubstituted imidazoles I (Ar = C6H5, 4-FC6H4, 3-HOC6H4, etc.). The results showed that the catalyst had high activity and the desired products were obtained in high yields within short reaction times. The best result was obtained at 120 °C in the presence of 0.02 g of the catalyst under solvent-free conditions. The catalyst was also readily recovered by an external magnet and could be used for several times without substantial reduction in its catalytic activity.

Different reactions of this compound(2,4,5-Triphenylimidazole)Synthetic Route of C21H16N2 require different conditions, so the reaction conditions are very important.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts