Tag: M.W=200-250

Skwierawska, Anna published the artcileRemoval of nonsteroidal anti-inflammatory drugs and analgesics from wastewater by adsorption on crosslinked β-cyclodextrin, Computed Properties of 42872-30-0, the main research area is nonsteroidal antiinflammatory drug analgesics removal adsorption wastewater crosslinked cyclodextrin.

We present a method using the material in the form of crosslinked β-cyclodextrin (CD) showing high efficiency in the simultaneous removal of hazardous pollutants from sewage, such as diclofenac (DIC), ibuprofen (IBU), ketoprofen (KETO), naproxen (NAPR), salicylic acid (SALI) and tramadol (TRAM). The material is stable and particularly easy to regenerate. The sorbent probably remembers the shape of the contaminants, which increases its sorption capacity after the second use. The kinetics of the KETO adsorption process from one-, two- and three-component solutions are well described by the pseudo-second-order model. The maximum polymer capacity was 162.60 mg g-1. The interactions of KETO with CD were investigated, indicating that the main sorption mechanism is based on supramol. interaction and uptake by a polymer network. The material is not sensitive to low pH and high salinity, so it can be used for the treatment of DIC, IBU, and KETO post-production wastewaters.

Water Resources and Industry published new progress about Adsorption. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Computed Properties of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Stefancich, Giorgio published the artcileResearch on nitrogen heterocyclic compounds. XII. Synthesis of 5H-pyrrolo[1,2-b][2]benzazepine derivatives, Application of 2-(2-(Bromomethyl)phenyl)acetonitrile, the main research area is pyrrolobenzazepine; carboxymethylbenzylpyrrole preparation cyclization; chloromethylbenzylpyrrolecarboxaldehyde cyclization.

Several routes to the unknown 5H-pyrrolo[1,2-b][2]benzazepine ring system have been explored. 1-(2-Cyanobenzyl)pyrrole was useful as starting material for 1-(2-carboxymethylbenzyl)pyrrole and 1-(2-chloromethylbenzyl)-2-pyrrolecarboxaldehyde. Polyphosphoric acid-catalyzed intramol. cyclization of the former substance and treatment of the latter compound with KCN led to 11-oxo-10,11-dihydo-5H-pyrrolo[1,2-b][2]benzazepine and to 10-cyano-5H-pyrrolo[1,2-b][2]benzazepine, resp., which were converted to the parent nucleus 5H-pyrrolo[1,2-b][2]benzazepine and its 10,11-dihydro- and 1,2,3,10,11,11a-hexahydro derivatives

Journal of Heterocyclic Chemistry published new progress about Cyclization. 73217-11-5 belongs to class nitriles-buliding-blocks, name is 2-(2-(Bromomethyl)phenyl)acetonitrile, and the molecular formula is C9H8BrN, Application of 2-(2-(Bromomethyl)phenyl)acetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Leowanawat, Pawaret published the artcileNi(COD)₂/PCy₃ catalyzed cross-coupling of aryl and heteroaryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates in THF at room temperature, Computed Properties of 214360-44-8, the publication is Journal of Organic Chemistry (2011), 76(24), 9946-9955, database is CAplus and MEDLINE.

Reaction conditions for the Ni(COD)₂/PCy₃ catalyzed cross-coupling of aryl neopentylglycolboronates with aryl mesylates were developed. By using optimized reaction conditions, Ni(COD)₂/PCy₃ was shown to be a versatile catalyst for the cross-coupling of a diversity of aryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates containing both electron-donating and electron-withdrawing substituents in their para, ortho, and meta positions in THF at room temperature This Ni-catalyzed cross-coupling of aryl neopentylglycolboronates is also effective for the synthesis of heterobiaryls and biaryls containing electrophilic functionalities sensitive to organolithium and organomagnesium derivatives In combination with the recently developed Ni-catalyzed neopentylglycolborylation, all Ni-catalyzed routes to functional biaryls and heterobiaryls are now easily accessible.

Journal of Organic Chemistry published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Computed Properties of 214360-44-8.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Kai published the artcileEfficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions, HPLC of Formula: 214360-44-8, the publication is Chemical Science (2016), 7(6), 3676-3680, database is CAplus and MEDLINE.

A rapid, chemoselective and metal-free C-B bond-forming reaction of aryl iodides and bromides in aqueous solution at low temperatures was discovered. This reaction is amenable to batch and continuous-flow conditions and shows exceptional functional group tolerance and broad substrate scope regarding both the aryl halide and the borylating reagent. Initial mechanistic experiments indicated a photolytically generated aryl radical as the key intermediate.

Chemical Science published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, HPLC of Formula: 214360-44-8.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhang, Xiao published the artcileSilver(I)-catalyzed carboxylation of arylboronic esters with CO₂, Recommanded Product: 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(50), 6292-6294, database is CAplus and MEDLINE.

A variety of arylboronic esters were efficiently carboxylated with CO₂ using a simple AgOAc/PPh₃ catalyst, affording the corresponding carboxylic acids in good yield. This simple and efficient silver(i) catalytic system showed wide functional group compatibility.

Chemical Communications (Cambridge, United Kingdom) published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C10H12O5, Recommanded Product: 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Yang, Chu-Ting published the artcileCopper-Catalyzed Cross-Coupling Reaction of Organoboron Compounds with Primary Alkyl Halides and Pseudohalides, Category: nitriles-buliding-blocks, the publication is Angewandte Chemie, International Edition (2011), 50(17), 3904-3907, S3904/1-S3904/108, database is CAplus and MEDLINE.

A copper-catalyzed cross-coupling of non-activated alkyl electrophiles with organoboron compounds has been developed. The use of LiOtBu as a base was found to be crucial to the reaction. The reaction is applicable to alkyl iodides, bromides, tosylates, mesylates, and even chlorides, and tolerates many more functional groups than the previously described copper-catalyzed coupling of Grignard reagents. It provides practically useful reactivities and may thus compliment palladium and nickel-catalyzed Suzuki-Miyaura coupling reactions of alkyl halides.

Angewandte Chemie, International Edition published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C4H7F3O2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xu, Jian-Xing published the artcileRuthenium-Catalyzed Carbonylative Coupling of Anilines with Organoboranes by the Cleavage of Neutral Aryl C-N Bond, Quality Control of 214360-44-8, the publication is Organic Letters (2020), 22(7), 2756-2760, database is CAplus and MEDLINE.

Herein, the first ruthenium-catalyzed Suzuki-type carbonylative reaction of electronically neutral anilines I (R¹ = H; R² = Me, F, Cl, t-Bu, H; R³ = H, F; R¹R² = -CH=CH-CH=CH-) and N,N-dimethyl-2-(pyrimidin-2-yl)aniline via C(aryl)-N bond cleavage was reported. Without any ligand and base, diaryl ketones II (R⁴ = 3-bromophenyl, 2,4,6-trimethylphenyl, 2-naphthyl, etc.) and phenyl(2-(pyrimidin-2-yl)phenyl)methanone can be obtained in moderate to high yields by using Ru₃(CO)₁₂ as the catalyst and chelation assisted by pyridine. The pyridine ring has a significant effect on both high efficiency and high regioselectivity in the cleavage of the aryl C-N bond in anilines.

Organic Letters published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C14H23N, Quality Control of 214360-44-8.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Duong, Hung A. published the artcileCobalt-Catalyzed Cross-Coupling Reactions of Arylboronic Esters and Aryl Halides, Application of 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, the publication is Organometallics (2017), 36(22), 4363-4366, database is CAplus.

An efficient cobalt catalyst system for the Suzuki-Miyaura cross-coupling reaction of arylboronic esters and aryl halides has been identified. In the presence of cobalt(II)/terpyridine catalyst and potassium methoxide, a diverse array of (hetero)biaryls have been prepared in moderate to excellent yields.

Organometallics published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Application of 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Ninglin published the artcileCobalt-Catalyzed Protodeboronation of Aryl and Vinyl Boronates, Formula: C12H14BNO2, the publication is Journal of Organic Chemistry (2021), 86(2), 1972-1979, database is CAplus and MEDLINE.

An efficient cobalt-based catalytic system for protodeboronation of various aryl and vinyl boronates ArR [R = 5,5-dimethyl-1,3,2-dioxaborinan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl, 1,3,2-dioxaborolan-2-yl, 4-oxo-1,2,3,4-tetrahydro-1,3,2-benzodiazaborinin-2-yl; Ar = 4-chlorophenyl, 4-(9H-carbazol-9-yl)benzen-1-yl, anthracen-2-yl, etc.]/(E/Z)-Ar¹CH=C(R¹)R² (Ar¹ = 4-bromophenyl, 1-benzothiophen-2-yl, pyridin-2-yl, etc.; R¹ = H, Ph, tetramethyl-1,3,2-dioxaborolan-2-yl; R² = Ph, 5,5-dimethyl-1,3,2-dioxaborinan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl) is described. The reaction is capable of tolerating a wide range of functional groups. The reaction is also extended to deuterodeboronation with D₂O, which provides a potential protocol for the synthesis of regiospecifically deuterated arenes and olefins R³D [R³ = 4-phenylphenyl, 3-(4-cyanophenyl)prop-1-en-1-yl, 4-(9H-carbazol-9-yl)benzen-1-yl, 2-(4-([6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amino)phenyl)ethenyl, etc.].

Journal of Organic Chemistry published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Formula: C12H14BNO2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Qu, Bingxue published the artcileDesign, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells, Formula: C13H17BN2O2, the publication is European Journal of Medicinal Chemistry (2022), 114257, database is CAplus and MEDLINE.

Multiple myeloma (MM) is a highly malignant hematol. cancer that occurs when an atypical plasma cell develops in the bone marrow and reproduces quickly. Despite varies of new drugs have been developed or under clinic trial, MM is still essentially incurable, while XPO1 inhibition has emerged as a promising therapeutic strategy in the treatment of MM. Using the second-generation XPO1 inhibitor KPT-8602 as the lead compound, structure-based optimization provided D4 with high anti-proliferation efficacy (IC50 = 24 nM in MM.1S). In addition, the treatment with D4 significantly induced MM.1S cell cycle arrested and cell apoptosis, which was confirmed as on-target effect by immunofluorescence microscopy and competitive binding assay. Moreover, D4 displayed good metabolic stability over rat plasma and liver microsomes, as well as good pharmacokinetic profile on SD rat model with high drug exposure and decent bioavailability by oral gavage. All these good properties of D4 pave the way for further drug development and clin. application.

European Journal of Medicinal Chemistry published new progress about 1036991-35-1. 1036991-35-1 belongs to nitriles-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, and the molecular formula is C13H17BN2O2, Formula: C13H17BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts