Tag: M.W=150-200

Liu, Hui; Yan, Yingkun; Zhang, Jiayan; Liu, Min; Cheng, Shaobing; Wang, Zhouyu; Zhang, Xiaomei published the artcile< Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines>, Computed Properties of 21667-62-9 , the main research area is aminoisoxazole quinone monoimine chiral phosphoric acid catalyst dearomative cycloaddition; benzofuroisoxazole diamine preparation enantioselective; quinone monimine aminoisoxazole phosphoric acid tandem dearomative cycloaddition cyclization; epoxyazenometheno dihydrobenzofuropyrrolyl benzenesulfonamide preparation enantioselective.

The first enantioselective dearomative [3+2] annulation of 5-aminoisoxazoles with quinone monoimines was realized using a chiral phosphoric acid as catalyst. Various novel (bridged) isoxazoline fused dihydrobenzofurans bearing two continuous quaternary stereocenters were achieved in moderate to good yields (up to 94%) with moderate to good enantioselectivities (up to 98% ee). The absolute configurations of two products were assigned by X-ray crystal structural analyses and a plausible reaction mechanism was proposed.

Chemical Communications (Cambridge, United Kingdom) published new progress about [3+2] Cycloaddition reaction catalysts (dearomative, stereoselective). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Computed Properties of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Weiqiang; Yang, Qin; Zhou, Tian; Tian, Qingshan; Zhang, Guozhu published the artcile< Enantioselective Synthesis of α-exo-Methylene γ-Butyrolactones via Chromium Catalysis>, SDS of cas: 94087-40-8, the main research area is aldehyde ethyl acrylate bromomethyl chromium allylation alkoxycarbonyl lactonization catalyst; butyrolactone methylene stereoselective preparation.

Enantioenriched α-exo-methylene γ-butyrolactones I [R = (CH2)2Ph, cyclohexyl, n-hexyl, cyclopropyl, Ph, 4-BrC6H4, 2-thienyl, etc.] have been obtained via a two-step sequence consisting of a highly enantioselective chromium-catalyzed carbonyl 2-(alkoxycarbonyl)allylation and lactonization. A variety of functional groups are compatible under the mild reaction conditions. The synthetic utility of this methodol. was demonstrated by two short derivatization transformations and the enantioselective synthesis of (+)-methylenolactocin.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, SDS of cas: 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guo, Rui; Xiao, Haijing; Li, Sijia; Luo, Yixin; Bai, Jiahui; Zhang, Mengzhen; Guo, Yinlong; Qi, Xiaotian; Zhang, Guozhu published the artcile< Photoinduced Copper-Catalyzed Asymmetric C(sp3)-H Alkynylation of Cyclic Amines by Intramolecular 1,5-Hydrogen Atom Transfer>, Reference of 94087-40-8, the main research area is cyclic amine photoinduced copper alkynylation alkyne hydrogen atom transfer; Amines; Asymmetric Synthesis; Copper Catalysis; Hydrogen Atom Transfer; Photochemistry.

The development of a mild and general method for C(sp3)-H functionalization of cyclic amines has been an ongoing challenge. In this work, authors describe the copper-catalyzed enantioselective C(sp3)-H alkynylation of unactivated cyclic 2-iodo-benzamide under photo-irradiation by intramol. 1,5-hydrogen atom transfer (HAT). The employment of a new bisoxazoline diphenylamine ligand, in conjunction with 1,1′-bi-2-naphthol, which significantly improved the reduction potential of the copper complex, was the key to success of this chem. Mechanistic and computational studies supported that the new copper complex served the dual role as a photoredox and coupling catalyst, the reaction went through a radical process, and the intramol. 1,5-HAT process was involved in the rate-limiting step. Apart from the broad substrate scope including unprecedented benzocyclic amines, this method also showed excellent diastereoselectivity in 2-monosubstituted cyclic amines via substrate control.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Reference of 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Pawan K.; Kumar, Rajiv; Ram, Sita; Chandak, Navneet published the artcile< Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions>, COA of Formula: C9H6ClNO, the main research area is ketonitrile preparation green chem one pot.

A one pot synthesis of β-ketonitriles RC(O)CH2CN (R = 4-bromophenyl, 3,4-dimethoxyphenyl, naphth-1-yl, etc.) and I from readily accessible 3-chloropropenals RCH(Cl)=CHCHO and 3-chloro-3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)prop-2-enal using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for the product synthesis.

Synthetic Communications published new progress about Green chemistry. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Prasad, A. S. G.; Rao, T. Bhaskara; Rambabu, D.; Basaveswara Rao, Mandava V.; Pal, Manojit published the artcile< Ultrasound Assisted Faster and Milder Approach to 6H-pyrido[1,2-a] quinazolin-6-imine Derivatives as Potential Inhibitors of PDE4>, Safety of 3-Chloro-2-fluorobenzonitrile, the main research area is aminopyridine Quinazolinimine pinner reaction bioactive agents potential inhibitor.

Background: The ultrasound assisted methodol. has been explored first time for the quicker synthesis of 6H-pyrido[1,2-a]quinazolin-6-imine derivatives via the reaction of 2-aminopyridines and 2-fluorobenzontriles under mild conditions. Methods: The methodol. is free from the use of any transition metal catalyst and afforded the desired products in good yields. Some of the synthesized compounds were evaluated for their potential PDE4 inhibition in silico and subsequently in vitro. Conclusion: One compound showed dose dependent inhibition of PDE4B and favorable pharmacol. properties indicating potential of this scaffold for the discovery of new inhibitors of PDE4.

Letters in Drug Design & Discovery published new progress about 94087-40-8. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Safety of 3-Chloro-2-fluorobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yoshida, Yu; Naoe, Yoshimitsu; Terauchi, Taro; Ozaki, Fumihiro; Doko, Takashi; Takemura, Ayumi; Tanaka, Toshiaki; Sorimachi, Keiichi; Beuckmann, Carsten T.; Suzuki, Michiyuki; Ueno, Takashi; Ozaki, Shunsuke; Yonaga, Masahiro published the artcile< Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist>, Name: 2-(3,4-Difluorophenyl)acetonitrile, the main research area is E2006 oral orexin receptor antagonist discovery SAR sleep disorder.

The orexin/hypocretin receptors are a family of G protein-coupled receptors and consist of orexin-1 (OX1) and orexin-2 (OX2) receptor subtypes. Orexin receptors are expressed throughout the central nervous system and are involved in the regulation of the sleep/wake cycle. Because modulation of these receptors constitutes a promising target for novel treatments of disorders associated with the control of sleep and wakefulness, such as insomnia, the development of orexin receptor antagonists has emerged as an important focus in drug discovery research. Here, we report the design, synthesis, characterization, and structure-activity relationships (SARs) of novel orexin receptor antagonists. Various modifications made to the core structure of a previously developed compound (-)-5 (I), the lead mol., resulted in compounds with improved chem. and pharmacol. profiles. The investigation afforded a potential therapeutic agent, (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006, II), an orally active, potent orexin antagonist. The efficacy was demonstrated in mice in an in vivo study by using sleep parameter measurements.

Journal of Medicinal Chemistry published new progress about Brain (brain penetrability). 658-99-1 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5F2N, Name: 2-(3,4-Difluorophenyl)acetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dong, Li-Na; Zhang, Shuai-Zheng; Zhang, Wan-Lu; Dong, Yao; Mo, Li-Ping; Zhang, Zhan-Hui published the artcile< Synthesis, characterization and application of magnetic biochar sulfonic acid as a highly efficient recyclable catalyst for preparation of spiro-pyrazolo[3,4-b]pyridines>, Formula: C9H6ClNO, the main research area is cobalt iron oxide biochar sulfonic acid magnetization adsorption stability.

A magnetic biochar sulfonic acid was prepared and characterized by fourier IR spectroscopy (FT-IR), powder x-ray diffraction technol., scanning electron microscope, transmission electron microscope and vibrating sample magnetometer techniques. The prepared catalyst exhibited excellent catalytic activity for synthesis of spiro-pyrazolo[3,4-b]pyridine derivatives via one-pot three-component reaction of 1H-pyrazol-5-amine, isatin and 3-oxo-3-phenylpropanenitrile. The catalyst could be readily recovered and reused several times without an obvious decay of catalytic performance.

Research on Chemical Intermediates published new progress about Adsorption. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeng, Ge; Liu, Jichao; Shao, Yinlin; Zhang, Fangjun; Chen, Zhongyan; Lv, Ningning; Chen, Jiuxi; Li, Renhao published the artcile< Selective Synthesis of β-Ketonitriles via Catalytic Carbopalladation of Dinitriles>, COA of Formula: C9H6ClNO, the main research area is dinitrile arylboronic acid palladium carbopalladation addition catalyst; ketonitrile preparation.

A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition of organoboron reagents to dinitriles has been developed. This method provides excellent functional-group tolerance, a broad scope of substrates, and the convenience of using com. available substrates. The method is expected to show further utility in future synthetic procedures.

Journal of Organic Chemistry published new progress about Addition reaction. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yadav, Maruti B.; Jeong, Yeon Tae published the artcile< A one-pot ring-closure and ring-opening sequence for the cascade synthesis of dihydrofurofurans and functionalized furans>, Application of C9H6ClNO, the main research area is dihydrofurofuran furan preparation triethylamine catalyst; aromatic aliphatic glyoxal cyanoacetophenone three component ring closure opening.

Authors have developed a simple novel ring-closure and ring-opening pathway using an organo-base system for the synthesis of highly substituted dihydrofurofuran and furan frameworks via a triethylamine-catalyzed one-pot three-component reaction. The protocol involved a Knoevenagel and Michael adduct via Paal-Knorr cyclization with aromatic/aliphatic glyoxal and 2-cyanoacetophenone under mild and heating conditions with excellent yields through a simple filtration method. The merits of this methodol., including the use of easily available feedstocks and an inexpensive catalyst, Gram-scale synthesis, wide functional group tolerance, an open-air reaction setup, and no need for workup and column-chromatog. procedures, make the developed methodol. a practical way to access dihydrofurofurans and functionalized furans.

Organic & Biomolecular Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent) (cyano). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Application of C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Crosby, John; Moilliet, Jock; Parratt, Julian S.; Turner, Nicholas J. published the artcile< Regioselective hydrolysis of aromatic dinitriles using a whole cell catalyst>, Name: Methyl 5-cyano-2-methylbenzoate, the main research area is regioselective hydrolysis aromatic dinitrile biochem catalyst; whole cell catalyst hydrolysis aromatic dinitrile.

A series of aromatic dinitriles have been examined as substrates for an immobilized whole cell Rhodococcus sp. that catalyzes the hydrolysis of nitriles to amides and/or carboxylic acids. The fluorinated aromatic dinitriles were regioselectivity hydrolyzed to the corresponding cyano amides whereas the non-fluorinated analogs were converted to cyano acids but with poorer regioselectivity.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Brevibacterium Role: CAT (Catalyst Use), USES (Uses). 103261-68-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C10H9NO2, Name: Methyl 5-cyano-2-methylbenzoate.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts