Tag: M.W=150-200

Abou Elmaaty, Tarek; Elsisi, Hanan; Negm, Elham; Ayad, Seif; Sofan, Mamdouh published the artcile< Novel nano silica assisted synthesis of azo pyrazole for the sustainable dyeing and antimicrobial finishing of cotton fabrics in supercritical carbon dioxide>, Quality Control of 21667-62-9 , the main research area is nano silica azo pyrazole dye synthesis cotton fabric dyeing; disperse reactive dye supercritical carbon dioxide antimicrobial finishing.

A new protocol was developed for the synthesis of azo pyrazole derivatives via one-pot reaction of β-ketonitriles and Ph hydrazines in the presence of nano SiO2 as a mild catalyst. The synthesized dyes were elucidated using spectrophotometry, mainly NMR, FTIR, UV as well as elemental anal. The dyeing was carried out utilizing supercritical carbon dioxide as a green medium. Outstanding deep color shades and excellent dye fixation were exhibited by all new dyes. Furthermore, the dyed samples revealed superlative color fastness. The biol. evaluation of both the dyestuffs and the dyed samples showed overgrowing antimicrobial activity against the tested microorganisms. Therefore, our findings assured that disperse reactive dyes are the most com. appropriate materials for dyeing cotton in supercritical carbon dioxide.

Journal of Supercritical Fluids published new progress about Antimicrobial agents. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Quality Control of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gore, Babasaheb Sopan; Kuo, Chiao-Ying; Garkhedkar, Amol Milind; Chang, Yu-Lun; Wang, Jeh-Jeng published the artcile< Metal-Free Solvent/Base-Switchable Divergent Synthesis of Multisubstituted Dihydrofurans>, Formula: C9H6ClNO, the main research area is ketonitrile cyclization; dihydropyran preparation.

A general protocol for the synthesis of multisubstituted 2,3-dihydrofuran-2-carbonitriles and 4,5-dihydrofuran-3-carbonitriles was demonstrated under a metal-free regime with the same oxidant, TBHP. By simply switching the reaction solvent and base, the reaction proceeds via two pathways. An unexpected -CN group migration rearrangement and hydroxylation have occurred in nonpolar and polar solvents, resp., under the reported conditions. Furthermore, the source of the hydroxyl group and hydrogen in the reaction is indirectly confirmed with isotope labeling studies.

Organic Letters published new progress about Crystal structure. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Hui; Yan, Yingkun; Li, Min; Zhang, Xiaomei published the artcile< An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines>, Formula: C9H6ClNO, the main research area is isoxazole amino oxindole preparation enantioselective chiral phosphoric acid catalyst; aminoisoxazole isatin boc ketimine aza Friedel Crafts.

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles I (R1 = C6H5, 4-OMeC6H4, 4-FC6H4, etc.; R2 = Me, Et, Bn, Allyl; R3 = H, 5-Me, 5-Cl, etc.; R4 = H, Me, Et, Bn, Boc) with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural anal. and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity.

Organic & Biomolecular Chemistry published new progress about Enantioselective synthesis. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghosh, Arun K.; Takayama, Jun; Aubin, Yoann; Ratia, Kiira; Chaudhuri, Rima; Baez, Yahira; Sleeman, Katrina; Coughlin, Melissa; Nichols, Daniel B.; Mulhearn, Debbie C.; Prabhakar, Bellur S.; Baker, Susan C.; Johnson, Michael E.; Mesecar, Andrew D. published the artcile< Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease>, Quality Control of 103261-68-3, the main research area is SARS CoV Coronavirus severe acute respiratory syndrome; naphthalene derivative SAR preparation antiviral agent.

We describe here the design, synthesis, mol. modeling, and biol. evaluation of a series of small mol., nonpeptide inhibitors of SARS-CoV PLpro. Our initial lead compound was identified via high-throughput screening of a diverse chem. library. We subsequently carried out structure-activity relationship studies and optimized the lead structure to potent inhibitors that have shown antiviral activity against SARS-CoV infected Vero E6 cells. Upon the basis of the X-ray crystal structure of inhibitor (III)-bound to SARS-CoV PLpro, a drug design template was created. Our structure-based modification led to the design of a more potent inhibitor, (I) (enzyme IC50 = 0.46 μM; antiviral EC50 = 6 μM). Interestingly, its methylamine derivative, (II), displayed good enzyme inhibitory potency (IC50 = 1.3 μM) and the most potent SARS antiviral activity (EC50 = 5.2 μM) in the series. We have carried out computational docking studies and generated a predictive 3D-QSAR model for SARS-CoV PLpro inhibitors.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 103261-68-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C10H9NO2, Quality Control of 103261-68-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Haoran; DiMagno, Stephen G. published the artcile< Room-temperature nucleophilic aromatic fluorination: experimental and theoretical studies>, Name: 3-Chloro-2-fluorobenzonitrile, the main research area is fluorination aromatic tetrabutylammonium fluoride; fluorobenzene preparation.

The use of anhydrous tetrabutylammonium fluoride in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes, was investigated. It was shown that TBAF permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.

Angewandte Chemie, International Edition published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Name: 3-Chloro-2-fluorobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Elmaaty, Tarek Abou; Sofan, Mamdouh; Kosbar, Tamer; Elsisi, Hanan; Negm, Ilham published the artcile< Green Approach to Dye PET and Nylon 6 Fabrics with Novel Pyrazole Disperse Dyes under Supercritical Carbon Dioxide and Its Aqueous Analogue>, Computed Properties of 21667-62-9, the main research area is polyethylene terephthalate nylon fabric pyrazole disperse dye; supercritical carbon dioxide green chem color property.

The development of a water-free dyeing process for synthetic fabrics is of great importance for the textile industry due to environmental and economic reasons. In this study, a series of novel 3-(3-chlorophenyl)-l-phenyl-4-(diazenyl derivatives)-lH-pyrazol-5-amine dyes were specifically synthesized for use with supercritical carbon dioxide. The new dyes were characterized by MS, IR, and NMR spectral data, and the results were found to be in good agreement with the proposed structures. The new dye stuffs were applied to dye polyester and nylon 6 fabrics under supercritical carbon dioxide and aqueous media. The color uptake expressed through the color strength (K/S) was assessed, and the values obtained showed that the dyeing of polyester and nylon 6 fabrics using the scCO2 method was significantly better than that using the aqueous method. The fastness properties of all the dyed fabrics were evaluated and exhibited excellent results. Raman micro spectroscopy indicated conclusively that the dye absorbance took place through all layers of the fabrics. Elimination of water and its costly processing can now be achieved in the dyeing of synthetic fabrics.

Fibers and Polymers published new progress about Anionic dispersants (Dispex). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Computed Properties of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mo, Xueling; Chen, Bin; Zhang, Guozhu published the artcile< Copper-Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α-Bromoamides>, Category: nitriles-buliding-blocks, the main research area is copper catalyst enantioselective Sonogashira coupling alkyne alpha bromoamide; Sonogashira reaction; copper catalysis; enantioselectivety; terminal alkynes; α-bromoamide.

An asym. copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides was developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylaniline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jadhav, Amol Maruti; Balwe, Sandip Gangadhar; Kim, Jong Su; Lim, Kwon Taek; Jeong, Yeon Tae published the artcile< Indium(III)chloride catalyzed synthesis of novel 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under solvent-free condition>, Related Products of 21667-62-9, the main research area is phthalhydrazide aryl aldehyde benzoylacetonitrile indium tandem three component cyclocondensation; aryl amino benzoyl pyrazolophthalazinedione preparation green chem; dioxopyridazine aryl aldehyde benzoylacetonitrile indium tandem three component cyclocondensation; amino aryl benzoyl pyrazolopyridazinedione preparation green chem.

An efficient, inexpensive and environmentally friendly synthesis of novel 3-amino-2-benzoyl-1-aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-dione and 3-amino-2-benzoyl-1-aryl-1H-pyrazolo[1,2-a]pyridazine-5,8-dione derivatives were developed via one-pot three-component reaction of phthalhydrazide or maleic hydrazide, aryl aldehydes and substituted benzoylacetonitriles in the presence of catalytic amount of InCl3 as a Lewis acid catalyst under solvent-free conditions. A mild reaction conditions, short reaction times, high yields and a wide range of functional group tolerance were the most important features of this protocol.

Tetrahedron Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Related Products of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feng, Jian-Bo; Wu, Xiao-Feng published the artcile< Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions>, Recommanded Product: 3-Chloro-2-fluorobenzonitrile, the main research area is pyridoquinazolinimine preparation; aminopyridine fluorobenzonitrile cyclization nucleophilic aromatic substitution; quinazolinamine preparation; amidine fluorobenzonitrile cyclization nucleophilic aromatic substitution.

A convenient procedure for the synthesis of pyrido[1,2-a]quinazolinimines e.g., I and quinazolinamines e.g., II was developed via cyclization of 2-fluorobenzonitriles with 2-aminopyridines or amidines resp. through SNAr reactions using potassium tert-butoxide as the promoter. Using this methodol., the desired pyrido[1,2-a]quinazolinimines and quinazolinamines were obtained in moderate to good yields under catalyst-free conditions.

Organic & Biomolecular Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Recommanded Product: 3-Chloro-2-fluorobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Du, Bingnan; Jiang, Xiaoqing; Sun, Peipei published the artcile< Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group>, Recommanded Product: 2-Chloro-4-methylbenzonitrile, the main research area is halosuccinimide ortho halogenation arylnitrile palladium catalyst; nitrile aromatic ortho halogenation halosuccinimide palladium catalyst.

A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature Using cyano as the directing group, the halogenation reaction gave good to excellent yields. E.g., in presence of Pd(OAc)2 and p-toluenesulfonic acid, reaction of PhCN and NIS gave 84% 2-IC6H4CN. The method is compatible for arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available at least the gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.

Journal of Organic Chemistry published new progress about Halogenation catalysts. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Recommanded Product: 2-Chloro-4-methylbenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts