Tag: M.W=150-200

Zhang, Ya-Kai; Wang, Bin published the artcile< Synthesis of α-Ketoamides from β-Ketonitriles and Primary Amines: A Catalyst-Free Oxidative Decyanation-Amidation Reaction>, Reference of 21667-62-9 , the main research area is ketoamide preparation; ketonitrile amine decyanation amidation.

AN oxidative decyanation-amidation of β-ketonitriles and primary amines readily occurs using hydrogen peroxide sodium carbonate adduct (Na2CO3·1.5H2O2), K2CO3, and 1,4-dioxane. This reaction affords α-ketoamides under mild conditions without the need of a catalyst.

European Journal of Organic Chemistry published new progress about Amidation. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Reference of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aldeborgh, Hannah; George, Kaylene; Howe, Morgan; Lowman, Heili; Moustakas, Holger; Strunsky, Nora; Tanski, Joseph M. published the artcile< Analysis of Small Molecule X-Ray Crystal Structures: Chemical Crystallography with Undergraduate Students in a Teaching Laboratory>, COA of Formula: C7H3ClFN, the main research area is mol xray crystal structure crystalline chem education analysis.

Abstract: The mol. structures of six small mol. organic compounds have been studied by X-ray diffraction in collaboration with undergraduate students enrolled in an advanced integrated laboratory course. The structures of 3-chloro-2-fluorobenzonitrile (1) [orthorhombic, P212121, a = 3.7679(13) Å, b = 12.546(4) Å, c = 13.780(5) Å], 5-chloro-2-fluorobenzonitrile (2) [monoclinic, P21/c, a = 3.7909(7) Å, b = 14.265(3) Å, c = 12.171(2) Å, β = 92.314(3)°], 2-bromo-3′-hydroxyacetophenone (3) [triclinic, P-1, a = 7.7081(3) Å, b = 9.8840(3) Å, c = 10.7320(4) Å, α = 98.4345(4)°, β = 90.6184(4)°, γ = 105.9259(4)°], 3-chlorobenzoylacetonitrile (4) [monoclinic, Cc, a = 4.8086(6) Å, b = 32.929(4) Å, c = 10.5855(13) Å, β = 97.665(1)°], 4-bromo-1-indanone (5) [triclinic, P-1, a = 7.3731(4) Å, b = 7.5419(4) Å, c = 8.2370(4) Å, α = 62.927(1)°, β = 71.160(1)°, γ = 71.521(1)°], and 4-bromo-1-indanol (6) [monoclinic, P21/c, a = 12.7914(9) Å, b = 4.6949(4) Å, c = 27.864(2) Å, β = 94.707(1)°] reveal several different types of intermol. interactions, such as hydrogen bonding, π-stacking, halogen-halogen interactions, and C-H···X (X = O, N, halogen) interactions. Graphical Abstract: The mol. structures of six small mol. organic compounds have been studied by X-ray diffraction in collaboration with undergraduate students enrolled in an advanced integrated laboratory course. The structures reveal several different types of intermol. interactions, such as hydrogen bonding, π-stacking, halogen-halogen interactions, and C-H···X (X = O, N, halogen) interactions.

Journal of Chemical Crystallography published new progress about Chemical education (undergraduate, organic). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, COA of Formula: C7H3ClFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dong, Li-Na; Zhang, Shuai-Zheng; Zhang, Wan-Lu; Dong, Yao; Mo, Li-Ping; Zhang, Zhan-Hui published the artcile< Synthesis, characterization and application of magnetic biochar sulfonic acid as a highly efficient recyclable catalyst for preparation of spiro-pyrazolo[3,4-b]pyridines>, Application In Synthesis of 21667-62-9, the main research area is cobalt iron oxide biochar sulfonic acid magnetization adsorption stability.

A magnetic biochar sulfonic acid was prepared and characterized by fourier IR spectroscopy (FT-IR), powder x-ray diffraction technol., scanning electron microscope, transmission electron microscope and vibrating sample magnetometer techniques. The prepared catalyst exhibited excellent catalytic activity for synthesis of spiro-pyrazolo[3,4-b]pyridine derivatives via one-pot three-component reaction of 1H-pyrazol-5-amine, isatin and 3-oxo-3-phenylpropanenitrile. The catalyst could be readily recovered and reused several times without an obvious decay of catalytic performance.

Research on Chemical Intermediates published new progress about Adsorption. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Application In Synthesis of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Subaramanian, Murugan; Ramar, Palmurukan M.; Rana, Jagannath; Gupta, Virendra Kumar; Balaraman, Ekambaram published the artcile< Catalytic conversion of ketones to esters via C(O)-C bond cleavage under transition-metal free conditions>, Application In Synthesis of 21667-62-9, the main research area is aryl ester preparation.

The catalytic conversion of ketones to esters ArC(O)OR [Ar = Ph, 2-furyl, 2-thienyl, etc.; R = Me, CN, Ph, etc.] via C(O)-C bond cleavage under transition-metal free conditions was reported. This catalytic process proceeded under solvent-free conditions and offers an easy operational procedure, broad substrate scope with excellent selectivity, and reaction scalability.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Application In Synthesis of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lai, Miao; Su, Fangyao; Hu, Jingyi; Wang, Mengzhuo; Zhao, Mingqin; Zhang, Ganlin published the artcile< Synthesis of N-heteroarenemethyl esters via C-C bond cleavage of acyl cyanides under transition metal-free conditions>, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is heteroarenemethyl ester acyl cyanide transition metal free condition; C-C bond cleavage; N-heteroaryl esters; N-heteroaryl methanols; acyl cyanides; transition-metal free synthesis.

A practical method to synthesize N-heteroaryl esters from N-heteroaryl methanols with acyl cyanides via C-C bond cleavage without using any transition metal is demonstrated here. The use of Na2CO3/15-crown-5 couple enables access to a series of N-heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about C-C bond cleavage. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Taldone, Tony; Patel, Pallav D.; Patel, Hardik J.; Chiosis, Gabriela published the artcile< About the reaction of aryl fluorides with sodium sulfide: investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via SNAr displacement of fluorine>, COA of Formula: C7H3ClFN, the main research area is mercaptobenzonitrile synthesis aryl fluoride sulfide substitution.

In this report we describe a simple synthesis of mercaptobenzonitriles from the reaction of fluorobenzonitriles with Na2S in DMF at room temperature and following direct treatment with Zn/HCl. Significantly, 2- and 4-fluorobenzonitriles substituted with chlorine or bromine, but not iodine, undergo selective substitution of fluorine at room temperature to yield synthetically useful halo-substituted mercaptobenzonitriles.

Tetrahedron Letters published new progress about Aromatic substitution reaction. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, COA of Formula: C7H3ClFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Chong; Yuan, Jing; Zhang, Zhenfeng; Gridnev, Ilya D.; Zhang, Wanbin published the artcile< Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center>, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is arylcyclopentanone enantioselective preparation; rhodium catalyst enantioselective intramol hydroacylation arylenal alkene isomerization; mechanism transition state energy rhodium catalyzed enantioselective hydroacylation arylenal; alkene isomerization; cycloketones; hydroacylation; rhodacycle; β-H elimination.

A new transformation pattern for enantioselective intramol. hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals such as I (or their Z isomers) were converted to C3- or C3,C5-chirogenic cyclopentanones such as II with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theor. calculated and the origin of the stereoselection is rationally explained.

Angewandte Chemie, International Edition published new progress about Cyclopentanones Role: SPN (Synthetic Preparation), PREP (Preparation) (3-aryl-2,2-disubstituted). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Osipyan, Angelina; Sapegin, Alexander; Novikov, Alexander S.; Krasavin, Mikhail published the artcile< Rare Medium-Sized Rings Prepared via Hydrolytic Imidazoline Ring Expansion (HIRE)>, Synthetic Route of 94087-40-8, the main research area is thiazepine dihydroimidazo alkyl halide hydrolytic imidazoline ring expansion; thiazecine preparation.

The hydrolytic imidazoline ring expansion (HIRE) methodol. was extended to readily available tetracyclic [1,4]thiazepines as well as sulfoxide and sulfone analogs thereof. The reactions resulted in the facile formation of a rare medium-sized [1,4,7]thiazecine ring system that has an emerging utility in bioactive compound design. Comparing the HIRE rates for representative compounds in the three groups of substrates allowed drawing some generalizations about the substituent effects on the course of the reaction.

Journal of Organic Chemistry published new progress about Alkylation. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Synthetic Route of 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shi, Yongjia; Gao, Qian; Xu, Senmiao published the artcile< Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes>, Category: nitriles-buliding-blocks, the main research area is chiral bidentate boryl ligand preparation catalyst iridium borylation cyclopropane; cyclopropanecarboxamide preparation iridium catalyzed enantioselective borylation; crystal structure chiral boryl cyclopropanecarboxamide; mol structure chiral boryl cyclopropanecarboxamide; bioactive Levomilnacipran enantioselective preparation.

The authors herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the 1st time. A variety of substrates with α-quaternary C centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. Also the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Journal of the American Chemical Society published new progress about Amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (boryl cyclopropanecarboxamides). 658-99-1 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5F2N, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yadav, Maruti B.; Jeong, Yeon Tae published the artcile< A one-pot ring-closure and ring-opening sequence for the cascade synthesis of dihydrofurofurans and functionalized furans>, COA of Formula: C9H6ClNO, the main research area is dihydrofurofuran furan preparation triethylamine catalyst; aromatic aliphatic glyoxal cyanoacetophenone three component ring closure opening.

Authors have developed a simple novel ring-closure and ring-opening pathway using an organo-base system for the synthesis of highly substituted dihydrofurofuran and furan frameworks via a triethylamine-catalyzed one-pot three-component reaction. The protocol involved a Knoevenagel and Michael adduct via Paal-Knorr cyclization with aromatic/aliphatic glyoxal and 2-cyanoacetophenone under mild and heating conditions with excellent yields through a simple filtration method. The merits of this methodol., including the use of easily available feedstocks and an inexpensive catalyst, Gram-scale synthesis, wide functional group tolerance, an open-air reaction setup, and no need for workup and column-chromatog. procedures, make the developed methodol. a practical way to access dihydrofurofurans and functionalized furans.

Organic & Biomolecular Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent) (cyano). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts