Tag: M.W=150-200

V., Bhavadhaarani published the artcileCombined treatment of synthetic textile effluent using mixed azo dye by phyto and phycoremediation, Recommanded Product: 2,3-Dimethoxybenzonitrile, the main research area is azo dye textile effluent phytoremediation bioadsorptive wastewater treatment; Phycoremediation; phytoremediation; textile effluent.

Phytoremediation is one of the biol. approaches for remediating textile dyeing effluents. The objective of this study is the use of Pistia stratiotes, an aquatic macrophyte, which was found to degrade the maximum of 83% of mixed azo dye. A phytoreactor was designed and constructed to scale up the process of phytoremediation by P. stratiotes to treat 40mg/l of synthetic textile effluent. Continuous flow phytoreactor fed with 40mg/l (cycle 1) which showed maximum decolorization of 84%, COD removal was about 61%, BOD which was reduced up to 71.9%, and TDS removal was about 72% resp. Further to remove the residual color and toxic effects of the dyes, Phycoremediation was followed for the mixed azo dyes using the microalgae Chlorella vulgaris which showed a maximum decolorization of 99% in the batch study and 74% in the scale-up study where the treated effluent was at the most minimal discharge. Phytotoxicity tests showed 80% of germination in treated effluent, and the plants in untreated wastewater had inhibited growth that indicates only 30% of germination. Such combined biol. treatment techniques were put forward to be the most eco-friendly technol., which is cost-effective and attain zero discharge of the textile effluent.

International Journal of Phytoremediation published new progress about Azo dyes. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Recommanded Product: 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Makosza, Mieczyslaw published the artcileNitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides, SDS of cas: 87331-46-2, the main research area is vicarious nucleophilic substitution nitroarylamine preparation; nitroarylamine preparation; arylamine nitro preparation; amination nitroarene sulfenamide.

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of amination.

Journal of Organic Chemistry published new progress about Amination. 87331-46-2 belongs to class nitriles-buliding-blocks, name is 2-Amino-3-nitrobenzonitrile, and the molecular formula is C7H5N3O2, SDS of cas: 87331-46-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Messick, Troy E. published the artcileBiophysical screens identify fragments that bind to the viral DNA-binding proteins EBNA1 and LANA, Product Details of C10H6N2O, the main research area is DNA EBNA1 LANA protein ligand interaction binding fragment NMR; biophys screen surface plasmon resonance saturation transfer difference; Epstein–Barr nuclear antigen 1; Epstein–Barr virus; Kaposi’s sarcoma associated herpesvirus (KSHV); fragment-based lead discovery; latency-associated nuclear antigen; protein–DNA interaction; saturation transfer difference-nuclear magnetic resonance; surface plasmon resonance.

The human gamma-herpesviruses Epstein-Barr virus (EBV) (HHV-4) and Kaposi’s sarcoma-associated herpesvirus (KSHV) (HHV-8) are responsible for a number of diseases, including various types of cancer. Epstein-Barr nuclear antigen 1 (EBNA1) from EBV and latency-associated nuclear antigen (LANA) from KSHV are viral-encoded DNA-binding proteins that are essential for the replication and maintenance of their resp. viral genomes during latent, oncogenic infection. As such, EBNA1 and LANA are attractive targets for the development of small-mol. inhibitors. To this end, we performed a biophys. screen of EBNA1 and LANA using a fragment library by saturation transfer difference (STD)-NMR spectroscopy and surface plasmon resonance (SPR). We identified and validated a number of unique fragment hits that bind to EBNA1 or LANA. We also determined the high-resolution crystal structure of one fragment bound to EBNA1. Results from this screening cascade provide new chem. starting points for the further development of potent inhibitors for this class of viral proteins.

Molecules published new progress about Affinity. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Product Details of C10H6N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Groen, Aaron C. published the artcileA novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly, Formula: C10H8FN, the main research area is FCPT ATPase inhibitor kinesin spindle pole assembly.

The tetrameric plus-end-directed motor, kinesin-5, is essential for bipolar spindle assembly. Small-mol. inhibitors of kinesin-5 have been important tools for investigating its function, and some are currently under evaluation as anti-cancer drugs. Most inhibitors reported to date are ‘non-competitive’ and bind to a specific site on the motor head, trapping the motor in an ADP-bound state in which it has a weak but non-zero affinity for microtubules. Here, we used a novel ATP-competitive inhibitor, FCPT, developed at Merck (USA). We found that it induced tight binding of kinesin-5 onto microtubules in vitro. Using Xenopus egg-extract spindles, we found that FCPT not only blocked poleward microtubule sliding but also selectively induced loss of microtubules at the poles of bipolar spindles (and not asters or monoasters). We also found that the spindle-pole proteins TPX2 and γ-tubulin became redistributed to the spindle equator, suggesting that proper kinesin-5 function is required for pole assembly.

Journal of Cell Science published new progress about Centrosome. 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Formula: C10H8FN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nelson, Derek W. published the artcileStructure-Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists, Name: 2,3-Dimethoxybenzonitrile, the main research area is enzylphenyltetrazole derivative SAR preparation P2X7 receptor antagonist.

1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X7 receptor. Structure-activity relationship (SAR) studies were conducted around both the benzyl and Ph moieties. In addition, the importance of the regiochem. substitution on the tetrazole was examined Compounds were evaluated for activity to inhibit calcium flux in both human and rat recombinant P2X7 cell lines using fluorometric imaging plate reader technol. Analogs were also assayed for their ability to inhibit IL-1β release and to inhibit P2X7-mediated pore formation in human THP-1 cells. Compound 15d was advanced to efficacy studies in a model of neuropathic pain where significant reversal of mech. allodynia was observed at doses that did not affect motor coordination.

Journal of Medicinal Chemistry published new progress about Allodynia. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Name: 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Islam, Sk Manirul published the artcilePolymer-anchored Ru(II) complex as an efficient catalyst for the synthesis of primary amides from nitriles and of secondary amides from alcohols and amines, Formula: C9H9NO2, the main research area is nitrile polymer anchored ruthenium complex hydration catalyst; primary amide preparation green chem; alc amine polymer anchored ruthenium complex oxidative coupling catalyst; secondary amide preparation green chem; polymer anchored ruthenium complex preparation hydration oxidative amidation catalyst.

A polymer-anchored ruthenium(II) catalyst was synthesized and characterized. Its catalytic activity was evaluated for the preparation of primary amides from aqueous hydration of nitriles in neutral condition. A range of nitriles were successfully converted to their corresponding amides in good to excellent yields. The catalyst was also effective in the preparation of secondary amides from the coupling of alcs. and amines. The catalyst can be facilely recovered and reused six times without a significant decrease in its activity.

Applied Organometallic Chemistry published new progress about Amidation. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Barrett, Anthony G. M. published the artcileOxazole synthesis with minimal purification: synthesis and application of a ROMPgel Tosmic reagent, Name: 4-(5-Oxazolyl)benzonitrile, the main research area is oxazole preparation ROMPgel Tosmic reagent.

The synthesis of ring opening metathesis, polymer-supported Tosmic reagent I, prepared in 7 steps from 4-bromothiophenol, is described. This reagent was utilized in the conversion of aldehydes to a small library of oxazoles in good yields and purities. Thus, reacting PhCHO with I gave oxazole II in 51% yield and 90% purity.

Organic Letters published new progress about Cyclization. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Name: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Campaigne, E. published the artcileCyclization of ylidenemalononitriles. VIII. Synthesis of coumarins from o-methoxybenzylidenemalonitriles, Formula: C9H9NO2, the main research area is coumarin; malononitrile benzylidene cyclization; cyclization benzylidenemalononitrile.

The coumarins I (R = H, Cl; R1 = H, 6-,7-,8-MeO) were prepared by direct cyclization of α-cyano-o-methoxycinnamates (II) in H2SO4. Alkoxy groups other than the o-methoxy group involved in lactone formation are not hydrolyzed during the reaction. The 3-cyano group on the resulting coumarin is not hydrated in concentrated H2SO4, but can be converted to the carbamido group in 90% sulfuric acid. In certain cases these conditions do cleave methoxy substituents on the coumarins. The indenones III can be obtained by cyclizing the II with BF3.Et2O.

Journal of Heterocyclic Chemistry published new progress about Cyclization. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Yicun published the artcileDesign, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity, Quality Control of 612-13-5, the publication is PLoS One (2011), 6(11), e27673, database is CAplus and MEDLINE.

Several haloperidol derivatives with a piperidine scaffold that was decorated at the nitrogen atom with different alkyl, benzyl, or substituted benzyl moieties were synthesized at our laboratory to establish a library of compounds with vasodilator activity. Compounds were screened for vasodilatory activity on isolated thoracic aorta rings from rats, and their quant. structure-activity relationships (QSAR) were examined Based on the result of QSAR, N-4-tert-Bu benzyl haloperidol chloride (16c) was synthesized and showed the most potent vasodilatory activity of all designed compounds 16C dose-dependently inhibited the contraction caused by the influx of extracellular Ca²⁺ in isolated thoracic aorta rings from rats. It concentration-dependently attenuated the calcium channel current and extracellular Ca²⁺ influx, without affecting the intracellular Ca²⁺ mobilization, in vascular smooth muscle cells from rats. 16C, possessing the N-4-tert-Bu benzyl piperidine structure, as a novel calcium antagonist, may be effective as a calcium channel blocker in cardiovascular disease.

PLoS One published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Miaomiao published the artcileTransition Metal-Free Oxidative Cross-Coupling Reaction of Activated Olefins with N-Alkyl Amides, Category: nitriles-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(5), 3989-3998, database is CAplus and MEDLINE.

The K₂S₂O₈-mediated transition metal-free oxidative cross-coupling reaction of activated olefins with N-alkyl amides was developed, and the reaction gave N-allylic amides in moderate to good yield. This reaction protocol was suitable for different kinds of activated olefins.

Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts