Tag: M.W=100-200

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33143-29-2 as follows. 33143-29-2

Generally, the reactions were performed using 0.3 mmol of substrate; 0.3 mmol of co-catalyst; 0.2 mmol of chlorobenzene (GC internal standard) and Jacobsen complex (15 mg, 0.024 mmol) as catalyst; in 4 mL of solvent with continuous stirring at the desired temperature. The oxidant (3 mmol) was added totally at the beginning of the reaction (slowly to prevent gas evolution) or progressively at a rate of 3 mmol h-1. The progress of the reaction was monitored by GC-FID, by removing small samples of the reaction mixture every 15 min. The relative proportions of compounds usually did not change from 30-45 min of reaction time, when oxidant was totally added at the beginning of the reaction or from 120-135 min when oxidant was progressively added to the reaction mixture.The epoxide stereoselectivity was determined by 1H NMR in comparison with published data for (-)-(1R,2S)-1,2-indene oxide [47,48] and (3R,4R)-6-cyan-2,2-dimethychromene [49] or by comparison of analytic standards for (R)-(+)-styrene oxide.

According to the analysis of related databases, 33143-29-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rocha, Mariana; Rebelo, Susana L.H.; Freire, Cristina; Applied Catalysis A: General; vol. 460-461; (2013); p. 116 – 123;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 622-75-3

Synthesis of PIDSB: PIDSB was prepared by knoevenagel condensation reaction.In a 100 mL round bottom flask, PICHO(8mmol, 3.18g),The p-benzenediacetonitrile (4 mmol, 0.63 g) was dissolved in 50 mL of tetrahydrofuran and 25 ml of t-butanol, and the temperature was raised to 46 C under a nitrogen atmosphere.1 ml of tetrabutylammonium hydroxide (TBAH) and a solution of 80 mg of potassium t-butoxide in tetrahydrofuran were prepared in advance.After half an hour of reaction, the system was poured into acetic acidified methanol solution at room temperature.The crude product was obtained by suction filtration and separated by column chromatography ( petroleum ether: methylene chloride = 1:5,The volume ratio) gave a red powdery solid (1.96 g, yield: 53%).Mass spectrum MALDI-TOF (m/z) [M+]: The found value was 917.56 and the theoretical value was 916.33.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 622-75-3.

Reference:
Patent; Jilin University; Lu Ping; Sun Xiaoyi; Li Jinyu; (13 pag.)CN108822040; (2018); A;,
Nitrile – Wikipedia,
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67832-11-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67832-11-5, name is 4-Bromo-2-methylbenzonitrile, A new synthetic method of this compound is introduced below.

4-bromo-2-methylbenzonitrile (1 mmol) was suspended in water (49 mL) and potassium hydroxide was added (50 mmol); the reaction mixture was stirred at reflux overnight. After cooling, the basic solution was washed with ethyl acetate (3 x 15 mL), acidified with hydrochloric acid (6M) and extracted with ethyl acetate (3 x 15 mL). The organic phase deriving from the acidic extraction was dried over anhydrous sodium sulfate and concentrated in vacuo, yielding the desired product as a white solid. Yield: 60%. TLC (dichloromethane – methanol 9:1): Rf = 0.46. Mp: 182C. 1H-NMR (300 MHz, CD3OD) delta (ppm) 7.80 (d, J = 8.4 Hz, 1H, H6), 7.48 (s, 1H, H3), 7.42 (d, J = 8.4 Hz, 1H, H5), 2.56 (s, 3H, CH3).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Chiarelli, Laurent R.; Mori, Matteo; Barlocco, Daniela; Beretta, Giangiacomo; Gelain, Arianna; Pini, Elena; Porcino, Marianna; Mori, Giorgia; Stelitano, Giovanni; Costantino, Luca; Lapillo, Margherita; Bonanni, Davide; Poli, Giulio; Tuccinardi, Tiziano; Villa, Stefania; Meneghetti, Fiorella; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 754 – 763;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts