Tag: M.W=100-200

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Chemistry of the phenoxathiins and isosterically related heterocycles. XXIX. The crystal and molecular structure of 5-(3-hydroxy-2-pyridylthio)-4-nitro-1-methylimidazole, the main research direction is crystal structure pyridylthioimidazole preparation; mol structure pyridylthioimidazole preparation; imidazole pyridylthio preparation crystal structure.Product Details of 4897-25-0.

Reaction of the dianion of 3-hydroxypyridine-2(1H)-thione with 5-chloro-4-nitro-1-methylimidazole led to the formation of 5-(3-hydroxy-2-pyridylthio)-4-nitro-1-methylimidazole (I), which did not cyclize to the desired pyrid[1,4]oxathiinoimidazole derivative In an effort to determine why I did not cyclize, its crystal structure was determined Both the conformation of I and electronic factors could be responsible for its non-cyclization.

Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)Product Details of 4897-25-0 require different conditions, so the reaction conditions are very important.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Schumacher, Christian; Fergen, Hannah; Puttreddy, Rakesh; Truong, Khai-Nghi; Rinesch, Torsten; Rissanen, Kari; Bolm, Carsten researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Product Details of 4556-23-4.They published the article 《N-(2,3,5,6-Tetrafluoropyridyl)sulfoximines: synthesis, X-ray crystallography, and halogen bonding》 about this compound( cas:4556-23-4 ) in Organic Chemistry Frontiers. Keywords: tetrafluoropyridyl sulfoximine preparation crystal mol structure; arylsulfoximine pentafluoropyridine mechanochem reation; halogen bonding Hirshfeld surface analysis. We’ll tell you more about this compound (cas:4556-23-4).

In the presence of KOH, NH-sulfoximines react with pentafluoropyridine to give N-(tetrafluoropyridyl)sulfoximines (NTFP-sulfoximines) I (R1 = Me, Ph, 4-MeC6H4, 4-ClC6H4, etc.; R = Me, i-Pr, 2-Py, 2-thiophenyl, etc.; ) in moderate to excellent yields. Either a solution-based or a superior solvent-free mechanochem. protocol can be followed. X-Ray diffraction analyses of 26 products provided insight into the bond parameters and conformational rigidity of the mol. scaffold. In solid-state structures, sulfoximines with halo substituents on the S-bound arene are intermolecularly linked by C-X···O=S (X = Cl, Br) halogen bonds. Hirshfeld surface anal. is used to assess the type of non-covalent contacts present in mols. For mixtures of three different S-pyridyl-substituted NTFP-sulfoximines and N-iodosuccinimide (NIS) in CDCl3, association constants were determined by 1H NMR spectroscopy. The data revealed a dependence of the halogen bond strength on the position of the pyridyl nitrogen indicating the presence of N-I···N(S-pyridyl) interactions. Neither the S=O oxygen nor the tetrafluoropyridyl-substituted nitrogen of the sulfoximine appeared to be involved in halogen bonding.

Different reactions of this compound(Pyridine-4-thiol)Product Details of 4556-23-4 require different conditions, so the reaction conditions are very important.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Recommanded Product: 4897-25-0.Singin, A. S.; Ovchinnikova, V. A.; Savin, Yu. I.; Safonova, T. S. published the article 《Synthesis of labeled sulfur-containing antitumorigenic preparations and study of their metabolism in the body》 about this compound( cas:4897-25-0 ) in Tezisy Dokl. Nauchn. Sess. Khim. Tekhnol. Org. Soedin. Sery Sernistykh Neftei, 14th. Keywords: purine imidazolylthio labeled; piperazine thiophosphoryl labeled; metabolism labeled sulfur. Let’s learn more about this compound (cas:4897-25-0).

Piperazine derivatives I and II were prepared in 70% yields by treatment of piperazine with 32PSCl3 or P35SCl3 followed by treatment with ethylenimine. Treatment of 6-hydroxypurine III (R = OH) with P235S5 gave III (R = 35SH) which was reacted with chloromethylnitroimidazole to give IV. The labeled compounds were useful in studying the mechanism of human metabolism

Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)Recommanded Product: 4897-25-0 require different conditions, so the reaction conditions are very important.

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COA of Formula: C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Synthesis of 1-methyl-4-nitro-5-substituted imidazole and substituted imidazolothiazole derivatives as possible antiparasitic agents. Author is Mukherjee, Anita; Kumar, Shiv; Seth, M.; Bhaduri, A. P..

Reactions of 5-chloro-1-methyl-4-nitroimidazole (I) with appropriate nucleophiles gave the desired 5-substituted imidazole derivatives Oxidation of I with CrO3 in AcOH furnished 1-methylimidazoline-2,4,5-trione. These compounds and 2 substituted imidazolothiazole derivatives were evaluated for their antileishmanial, antiamebic, and anthelmintic activities. None of the compounds exhibited any noteworthy activity for drug developmental work.

Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)COA of Formula: C4H4ClN3O2 require different conditions, so the reaction conditions are very important.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Helvetica Chimica Acta called Synthesis of heteroxanthine from a derivative of imidazole, Author is Sarasin, J.; Wegmann, E., which mentions a compound: 4897-25-0, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2, Recommanded Product: 4897-25-0.

S. and W. describe a new synthesis of 7-methylxanthine from an imidazole derivative, by closing the pyrimidine ring, an operation which has not been previously effected. 1-Methyl-4-nitro-5-chloroimidazole (I) is obtained in theoretical yield from 1-methyl-5-chloroimidazole (b. 200°) (II) by dissolving in dilute HNO3 to form the nitrate, treating the latter with cold concentrated H2SO4, heating the mixture on the water bath for 2 hrs., and pouring the product on ice; it m. 147-8°, and is insoluble in acids and dilute alkalies. The isomeric 1-methyl-5-nitro-4-chloroimidazole (III), obtained by the same method from 1-methyl-4-chloroimidazole; m. 77-8°. I and III are reduced at 0° by Sn and HCl to the corresponding methylchloroaminoimidazoles which were not obtained in the pure state. I heated for several hrs. on the H2O bath in EtOH with 2 mols. KCN and 0.1 mol. KI yields 85% 1-methyl-4-nitro-5-cyanoimidazole (IV), m. 141-2°, insoluble in acids and dilute alkalies. 1-Methyl-4-nitroimidazole-5-carboxamide (V), obtained in 90% yield when IV is heated for 2 hrs. on the H2O bath with 8 times its weight of concentrated H2SO4 and the product is poured on ice, m. 257-8° (decomposes), insoluble in acids and alkalies, saponified with great difficulty; a small amount of the acid (VI) is obtained by prolonged action of concentrated HCl. VI m. 160° with evolution of CO2 and formation of 1-methyl-4-nitroimidazole (VII), m. 133-40°, which is also obtained by heating V in a sealed tube at 120° with HCl. Reduction of VII by Sn and HCl at 0° and hydrolysis of the product by heating under pressure with HCl, gives NH4Cl and sarcosine-HCl, m. 168-9°; this reaction establishes the constitution of II and VII. V is reduced at 0° by Sn and HCl to the corresponding amine, 1-methyl-4-aminoimidazole-5-carboxamide (VIII), m. 184-5°, decomposed when heated with water or dilute alkalies with evolution of NH3; HCl salt, m. 214-5°. 7-Methylxanthine (heteroxanthine) obtained in 38% yield by heating 0.4 g. of VIII for 8 hrs. in a sealed tube at 160-70° with an equal weight of CO(OEt)2, m. 380° (browning and evolution of gas). A mixture of the substance with heteroxanthine prepared from theobromine melts at the same temperature The murexide reaction is given with KClO3 and HCl.

《Synthesis of heteroxanthine from a derivative of imidazole》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Recommanded Product: 4897-25-0.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-4-thiol(SMILESS: SC1=CC=NC=C1,cas:4556-23-4) is researched.COA of Formula: C21H16N2. The article 《Long-Range Surface Plasmon Resonance Configuration for Enhancing SERS with an Adjustable Refractive Index Sample Buffer to Maintain the Symmetry Condition》 in relation to this compound, is published in ACS Omega. Let’s take a look at the latest research on this compound (cas:4556-23-4).

We propose a method to maintain the symmetry condition of the refractive index with respect to a dielec. buffer layer for a long-range surface plasmon resonance (LRSPR) configuration. The symmetry condition was maintained by changing the concentration of the ethylene glycol aqueous solution (sample buffer layer) to match the refractive index of the MgF2 film. Maintenance of the symmetry condition is necessary for exciting the LRSPR mode and increasing the elec. field intensity near the film. We used a four-phase Kretschmann resonance setup composed of a K9 prism, MgF2 film, Ag film, and sample buffer layer. The incident angle-dependent surface-enhanced Raman scattering (SERS) spectra were measured in the evanescent field. At the SPR angle, the SERS signal of the sym. configuration was 60 times higher than that of the conventional SPR configuration. Moreover, the elec. field penetration depth of the sym. long-range surface plasmon configuration (>1000 nm) was longer than that of their asym. counterparts. The enhancement factor of the sym. configuration was 8.6 x 107, which corresponded to the lowest detectable concentration for 4-mercaptopyridine, reaching 1.0 x 10-10 M at the resonance angle. Thus, the sym. LRSPR configuration has great potential for label-free sensing and detection of macromols. and biomols.

《Long-Range Surface Plasmon Resonance Configuration for Enhancing SERS with an Adjustable Refractive Index Sample Buffer to Maintain the Symmetry Condition》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridine-4-thiol)Application In Synthesis of Pyridine-4-thiol.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Gold-patterned microarray chips for ultrasensitive surface-enhanced Raman scattering detection of ultratrace samples, published in 2019, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Electric Literature of C5H5NS.

This paper reports the fabrication of gold-patterned microarray chips for fast and ultrasensitive surface enhanced Raman scattering (SERS) detection of trace samples. By micro-nano machining based on electron-beam lithog., magnetron sputtering, and chem. modification, gold-patterned microarray chips with hydrophilic and hydrophobic periodic structures are fabricated, and a polyethylene glycol (PEG) layer is coated on the surface of the gold well, making the chips long-term stable. The hydrophilic surface of each gold well is surrounded by a hydrophobic layer, which makes the ultratrace sample amount for SERS measurement only 0.3μl. In the detection of malachite green (MG), 4-mercaptopyridine (4-MPY), rhodamine 6G (R6G), and melamine, great enhanced SERS signals with the detection limit reaching nM level can be achieved due to the enrichment effect of the periodic structures and the hot-spots generated between the sandwich structure built on the gold wells. Such gold-patterned microarray chip is promising in fast and ultrasensitive SERS detection of various chem. and biol. species with trace amount

《Gold-patterned microarray chips for ultrasensitive surface-enhanced Raman scattering detection of ultratrace samples》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridine-4-thiol)Electric Literature of C5H5NS.

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Synthetic Route of C5H5NS. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Optical properties of two bismuth(III) halide hybrids with pyridyl sulfide derivative counter cations. Author is Wang, Zihan; Dan, Qingjuan; Zhao, Ruo-Yu; Xu, Rang-Dong; Liu, Guang-Ning; Li, Cuncheng.

Low dimensional organic-inorganic hybrid Bi(III) halides, especially those containing organic N, S-heterocycles are amazing as solid state photoluminescent materials, but remain less explored. Herein, two bismuth(III) halide compounds, (Etmp)4Bi2X10 (X = Cl for 1, Br for 2, Etmp = 4-(ethylthio)pyridin-1-ium), were obtained by employing pyridyl sulfide derivative as countercations. They are determined as zero-dimensional (0D) ionic structures, featuring binuclear bismuth halide anions charge-compensated by (Etmp)+ countercations. Solid-state UV-visible diffuse reflectance spectra reveal the wide optical band gaps of 3.20 eV for 1 and 2.67 eV for 2. Notably, 1 exhibits a strong green photoluminescence emission with a quantum yield of 20%, and a CIE chromaticity coordinate of (0.27, 0.36) when irradiated by a 394-nm light. Theor. calculations suggest that the charge transition between Cl-3p and p-π* anti-bonding orbital of (Etmp)+ is responsible for the emission.

《Optical properties of two bismuth(III) halide hybrids with pyridyl sulfide derivative counter cations》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridine-4-thiol)Synthetic Route of C5H5NS.

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Safety of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?. Author is Clarke, Eric D.; Wardman, Peter.

Reduction of 5-chloro-1-methyl-2-nitroimidazole (I) using HCO2-/N2O reducing system was characterized, and calculations at 450 nm and pH 2.2-8.3 gave a pKa of 3.3 for the prototropic equilibrium Experiments on the rate of oxidation of I radical by Fe(CN)63- demonstrated that reduction of I by the Me2CHOH/N2O system gave a radical with unit neg. charge at pH 8.2 which was oxidized by Fe(CN)63-. At 410 nm, the I radical produced in the HCO2- system was extremely long-lived at pH >7; the rate of decay increased progressively as pH was lowered and second order rate constants for radical-radical reaction were estimated γ-Radiolysis of N2O-saturated solutions containing I and HCO2- (concentration ratio of HCO2- to I ≃100) at pH 7.4 and 310 nm and Na2S2O4 anaerobic reduction of I indicated that dissociative electron attachment occurs, producing Cl- with high efficiency. The radical produced initially upon reaction of I with simple one-electron reducing agents behaves as a normal nitroimidazole radical-anion on the timescale of pulse radiolysis measurements. If the radical-anion of I dissociates to yield Cl- and a neutral radical, it does so only at times >1 s at pH 7, i.e. possibly accompanying the disproportionation or other reaction of 2 radicals.

《Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Safety of 5-Chloro-1-methyl-4-nitroimidazole.

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Quality Control of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Occupational allergic contact dermatitis from 5-chloro-1-methyl-4-nitroimidazole. Author is Jolanki, Riitta; Alanko, Kristiina; Pfaffli, Pirkko; Estlander, Tuula; Kanerva, Lasse.

A 46-yr old man, working on azathioprine synthesis, developed a rash on the face, especially the eyelids, neck, and hands, after minimal exposure to the drug intermediate, AZA III, in powder form, when he weighed the chem. in small amounts without using protective gloves. This contact allergy to 5-chloro-1-methyl-4-nitroimidazole, an intermediate product of azathioprine, had not been previously reported. This compound was shown to be present in the end products, azathioprine and azathioprine tablets, in amounts sufficient to induce allergic patch test reactions in a sensitized patient. Cross-reactivity was found between 5-chloro-1-methyl-4-nitroimidazole and 3 of 6 imidazole derivatives used as antifungal drugs tested.

Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)Quality Control of 5-Chloro-1-methyl-4-nitroimidazole require different conditions, so the reaction conditions are very important.

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