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Fu, Yuanyuan; Zhao, Xueyan; Chen, Dengfeng; Luo, Jinyue; Huang, Shenlin published an article about the compound: Pyridine-4-thiol( cas:4556-23-4,SMILESS:SC1=CC=NC=C1 ).Electric Literature of C5H5NS. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4556-23-4) through the article.

A Cu-catalyzed coupling reaction of indanone oxime acetates I (R = H, Me, MeO, Br, R1 = H, MeO, Cl, Br, steroid Q, R2 = H, Br, CN, CF3) with thiols R3SH (R3 = n-dodecyl, 2-naphthyl, pyridin-4-yl, etc.) has been developed for the synthesis of 2,3-functionalized 1-indenones II. This protocol has several features including easy mild reaction conditions, stabilized enamine products, good tolerance of functional groups, and no external oxidants. The reaction enables direct derivatization on the indanone ring to provide valuable functionalized indenones at room temperature

This compound(Pyridine-4-thiol)Electric Literature of C5H5NS was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C4H4ClN3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Some examples of anomalous radiosensitizing behavior of electron-affinic compounds in vitro. Author is Watts, M. E.; Jacobs, R. S..

The radiosensitizing activities of several nitroheterocyclic compounds for x-irradiated cells differ from the general patterns repeated for a number of nitroarom. and nitroheterocyclic compounds (sensitizing efficiency related to electron affinity, dose dependence of affect, and radiosensitization of hypoxic but not oxygentated cells). CMNI (I) [4897-25-0] was a much more potent radiosensitizer than predicted from its redox potential, L 6993 (II) [23571-52-0] extended a fairly constant effect over the concentration range 10-6-10-2M, and furaspor (III) [586-84-5] radiosensitized both hypoxic and oxygenated cells. Possible mechanisms for these anomalous effects are discussed.

This compound(5-Chloro-1-methyl-4-nitroimidazole)COA of Formula: C4H4ClN3O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Nitrile – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4897-25-0, is researched, Molecular C4H4ClN3O2, about The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds. I. Synthesis of azathioprine, the main research direction is azathioprine optimized preparation; chloroimidazole reaction mercaptopurine; imidazole chloro reaction mercaptopurine; purine mercapto reaction chloroimidazole.Category: nitriles-buliding-blocks.

The reaction conditions for the synthesis of azathioprine (I) were optimized with the help of UV spectroscopy. Thus, 0.029 mol imidazole II in 25 cm3 DMF was stirred into 0.029 mol 6-mercaptopurine hydrate in 15 cm3 DMF, 20 cm2 THF, and 40 cm3 25% aqueous NH4OH and the mixture heated to 70-90° 1.5 h to give 95% crude azathioprine, purified to give 80% product.

This compound(5-Chloro-1-methyl-4-nitroimidazole)Category: nitriles-buliding-blocks was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Nitrile – Wikipedia,
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Name: 5-Chloro-1-methyl-4-nitroimidazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Nitroimidazoles. Part V. Chloronitroimidazoles from dinitroimidazoles. A reinvestigation. Author is Suwinski, Jerzy; Salwinska, Ewa; Watras, Jan; Widel, Maria.

5(4)-Chloro- and 2-chloro-4(5)-nitroimidazole or their N-Me derivatives were prepared by ≥2 independent routes. Contrary to some former reports, only 2-chloro-4-(or 5)-nitroimidazoles were obtained from 2,4(or 5)-dinitroimidazoles. In 4,5-dinitroimidazoles only a nitro group in the 5 position was replaced by a chlorine atom.

《Nitroimidazoles. Part V. Chloronitroimidazoles from dinitroimidazoles. A reinvestigation》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Name: 5-Chloro-1-methyl-4-nitroimidazole.

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Nitrile – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.COA of Formula: C21H16N2. The article 《A validated UPLC method for the determination of process-related impurities in Azathioprine bulk drug》 in relation to this compound, is published in Analytical Methods. Let’s take a look at the latest research on this compound (cas:4897-25-0).

An UPLC method was developed and subsequently validated for the determination of Azathioprine and its process-related impurities. Separation was achieved with Acquity UPLC BEH C18, 100 × 2.1 mm, 1.7 μm column and trifluoroacetic acid (0.05% in water): acetonitrile as eluent in gradient mode. Flow rate was set at 0.35 mL min-1. UV detection was performed at 220 nm. The method was validated with respect to specificity, accuracy, precision, linearity, robustness, limit of quantification, and limit of detection. The accuracy of the method demonstrated at 3 levels in the range of 50-150% of the specification limit and the recovery of impurities were found to be in the range of 98 to 102%. The detection limits of the process related impurities ranged between 0.16 and 0.24 μg mL-1. The described method is simple, rapid, linear, precise, and robust. The method is useful during process development and quality control of bulk manufacturing

This compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Nitrile – Wikipedia,
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Related Products of 4556-23-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Electrochemically Promoted Nickel-Catalyzed Carbon-Sulfur Bond Formation. Author is Wang, Yang; Deng, Lingling; Wang, Xiaochen; Wu, Zhengguang; Wang, Yi; Pan, Yi.

This work describes a nickel-catalyzed Ullmann-type thiolation of aryl iodides under mild electrochem. conditions. The simple undivided cell with graphite felt/nickel foam electrode setups offers excellent substrate tolerance, affording aryl and alkyl sulfides in good chem. yields. Furthermore, the mechanism for this electrochem. cross-coupling reaction has been investigated by cyclic voltammetry.

This compound(Pyridine-4-thiol)Related Products of 4556-23-4 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Nitrile – Wikipedia,
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Das, Sumit Kumar; Bhattacharya, Tara Shankar; Chowdhury, Joydeep published an article about the compound: Pyridine-4-thiol( cas:4556-23-4,SMILESS:SC1=CC=NC=C1 ).Recommanded Product: Pyridine-4-thiol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4556-23-4) through the article.

Reported the wavelength-scanned (WS) SERS spectra of 4-mercaptopyridine mols. (4-MPy) adsorbed on Au nanoparticles immobilized in a Langmuir Reverse Schaefer (L-RSh) film matrix of 5CB mols. The WS-SERS spectral profile exhibited an increment in the intensity of the enhanced Raman bands of 4-MPy with an increase in the wavelength of the excitation laser source. The rationale behind the exptl. observations was supported by the simulated extinction spectra and the enhancement factor measurements of the modeled systems using the T-matrix formalism. The SERS intensity fluctuations in the band located at 1000 cm-1 for the 4-MPy mol., as obtained from 3 different locations in the L-RSh film substrate, were analyzed. Depending on the spatial locations of the substrates, the intensity fluctuations of the abovementioned band exhibit both Poisson and Gaussian distributions but the maximum number of probe mols. that can reside in the scattering areas under study cannot exceed 16. Probably the origin of SERS from single/few mols. or from the ensemble-averaged system cannot be inferred from the statistical distributions of the Raman intensity fluctuations. The present exptl. observations also revealed the relation between the near-field plasmonic behaviors of the substrate with the corresponding far-field SERS spectra of the 4-MPy mol.

This compound(Pyridine-4-thiol)Recommanded Product: Pyridine-4-thiol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Nitrile – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole.Carvalho, Alcione S.; Ferreira, Edmir F.; Soares, Renata O. A.; Souza, Adriano S.; Pinto, Angelo C.; Bozza, Marcelo; Boechat, Nubia published the article 《Synthesis of azoles distinguishing a trifluoromethyl derivative with potent dual anti-Trypanosoma cruzi activity and cell growth inhibitions》 about this compound( cas:4897-25-0 ) in Fluorinated Bioactive Compounds in the Agricultural & Medical Fields, Proceedings of the Conference, Brussels, Sept. 13-15, 1999. Keywords: conference trifluoromethyl azole preparation trypanosomicide; nitroimidazolyl trifluoromethyl triazolamine preparation trypanosomicide; proliferation inhibitor methylnitropyrazolylimidazole methylnitroimidazolyl triazolamine preparation; nitro pyrazolyl imidazole preparation trypanosomicide. Let’s learn more about this compound (cas:4897-25-0).

A conference report. The synthesis of N-(1-methyl-4-nitro-1H-imidazol-5-yl)-5-(trifluoromethyl)-1H-1,2,4-triazol-3-amine and 1-methyl-4-nitro-5-(1H-pyrazol-1-yl)-1H-imidazole and their trypanosomicidal activity were reported.

This compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Robust quantitative SERS analysis with Relative Raman scattering intensities, published in 2021-01-01, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Electric Literature of C5H5NS.

Robust quant. anal. methods are very attractive but challenging with surface-enhanced Raman scattering (SERS) technique till now. Quant. anal. methods using absolute Raman scattering intensities tend to desire very critical reproducibility of SERS substrates and consistency of testing conditions, as batch differences and inhomogeneity of SERS substrates as well as the fluctuation of measuring parameters placed challenging obstacles. Relative Raman scattering intensities, however, can release the adverse interferences mentioned above and provide effective and robust information as it is independent of the reproducibility of SERS substrates. By establishing external calibration working curves, the authors achieved accurate mol. composition prediction of mols. in multi-component systems. Further, by choosing or adding a label mol. with known concentration as Raman internal standards, the concentration of target mols. can be easily predicted. This approach proved the effectiveness and robustness of quant. anal. with the relative Raman scattering intensities, even carried out with a flexible inhomogeneous SERS substrate.

This compound(Pyridine-4-thiol)Electric Literature of C5H5NS was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
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Reference of 5-Chloro-1-methyl-4-nitroimidazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Determination of two related substances in azathioprine tablets by HPLC.

An HPLC method was developed to determine 6-mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole, which were related substances of azathioprine tablets. An ODS C18 column (250 mm × 4.6 mm, 5 μm) was used with the mobile phase of a mixture of sodium heptanesulfonate solution (sodium heptanesulfonate 1.336 g, dissolved in 850 mL water)-methanol (85:15, adjust the solution with 1 mol/L-1 hydrochloric acid to a pH of 3.5) at a flow rate of 1.0 mL/min-1. The detection wavelength was at 254 nm. For 6-mercaptopurine, the calibration curve was linear in the range of 4. 68 ± 10-4 to 0.014 mg/mL-1 with correlation coefficient 0.9997 and the regression equation being Y = 5400X-0.5302. The average recovery (n = 9) was 99.5%, and the detection limit was 1 ng . For 5-chloro-1-methyl-4-nitroimidazole, the calibration curve was also linear in the range of 5. 51 ± 10-4 to 0.0165 mg/mL-1 with correlation coefficient 0.9994 and the regression equation being Y = 6743X-1.396, the average recovery (n = 9) was 99.7%, and the detection limit was 2.5 ng. Sample solution and standard solution are all stable within 8 h. This method is specific, accurate, sensitive, and simple.

《Determination of two related substances in azathioprine tablets by HPLC》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Reference of 5-Chloro-1-methyl-4-nitroimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts