Tag: M.W=100-150

An article Modular Dual-Tasked C-H Methylation via the Catellani Strategy WOS:000490358900033 published article about PALLADIUM-CATALYZED ALKYLATION; LATE-STAGE FUNCTIONALIZATION; AROMATIC FUNCTIONALIZATION; SELECTIVE ALKYLATION; COUPLING REACTIONS; ARYL IODIDES; REAGENTS; BONDS; ACTIVATION; NORBORNENE in [Gao, Qianwen; Shang, Yong; Song, Fuzhen; Ye, Jinxiang; Liu, Ze-Shui; Li, Lisha; Cheng, Hong-Gang; Zhou, Qianghui] Wuhan Univ, Engn Res Ctr Organosilicon Cpds & Mat, Sauvage Ctr Mol Sci, Coll Chem & Mol Sci,Minist Educ, Wuhan 430072, Peoples R China; [Zhou, Qianghui] Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China in 2019, Cited 91. Recommanded Product: 95-11-4. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4

We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and methylating reagent, respectively. Six types of ipso terminations can modularly couple with this ortho C-H methylation to constitute a versatile methylation toolbox for preparing diversified methylated arenes. This toolbox features inexpensive methyl sources, excellent functional-group tolerance, simple reaction procedures, and scalability. Importantly, it can be uneventfully extended to isotope-labeled methylation by switching to the corresponding reagents CD3OTs or (CH3OTs)-C-13. Moreover, this toolbox can be applied to late-stage modification of biorelevant substrates with complete stereoretention. We believe these salient and practical features of our dual-tasked methylation toolbox will be welcomed by academic and industrial researchers.

Recommanded Product: 95-11-4. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Gao, QW; Shang, Y; Song, FZ; Ye, JX; Liu, ZS; Li, LS; Cheng, HG; Zhou, QH or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C8H9N. Recently I am researching about BOVINE CORNEAL OPACITY; TIME EXPOSURE TEST; HPLC/UPLC-SPECTROPHOTOMETRY; HAZARD IDENTIFICATION; APPLICABILITY DOMAIN; CHEMICALS; ASSAY; VALIDATION, Saw an article supported by the . Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Alepee, N; Adriaens, E; Abo, T; Bagley, D; Desprez, B; Hibatallah, J; Mewes, K; Pfannenbecker, U; Sala, A; Van Rompay, AR; Verstraelen, S; McNamee, P. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile

The focus of Cosmetics Europe’s programme on serious eye damage/eye irritation is on development of testing strategies and defined approaches for identification of ocular effects of chemicals in the context of OECD’s Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation. Cosmetics Europe created a comprehensive database of chemicals for which in vitro data are available with corresponding historical in vivo Draize eye data. This database allowed further exploration of the initially proposed strategies from the CON4EI project and to identify opportunities for refinement. The current analysis focused on the development of a defined approach, applicable to liquid non-surfactant chemicals, neat and in dilution, that can distinguish between the three UN GHS categories (Cat. 1, Cat. 2, and No Cat.). Combining the modified-protocol Short Time Exposure (STE) test method (OECD TG 491 with extension to highly volatile substances) with the Bovine Corneal Opacity and Permeability Laser Light-Based Opacitometer (BCOP LLBO) test method in a Bottom-Up approach identified 81.2% Cat. 1, 56.3% Cat. 2, and 85.3% No. Cat correctly, with an NPV of 96.7% and a PPV of 68.6%. Therefore, the performance of the defined approach was better than the standalone test methods.

COA of Formula: C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Alepee, N; Adriaens, E; Abo, T; Bagley, D; Desprez, B; Hibatallah, J; Mewes, K; Pfannenbecker, U; Sala, A; Van Rompay, AR; Verstraelen, S; McNamee, P or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts