Tag: M.W=100-150

Leanez, Jacques published the artcileAnti-leishmanial effect of spiro dihydroquinoline-oxindoles on volume regulation decrease and sterol biosynthesis of Leishmania braziliensis, Product Details of C7H6N2, the main research area is Leishmania macrophage spiro dihydroquinoline oxindole sterol antileishmania; Leishmania braziliensis; chemotherapy; parasite internal regulation; spiro dihydroquinoline-oxindoles; squalene epoxidase inhibitors; sterol pathway.

Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF3·OEt2-catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans-isoeugenol. Ten spiro-oxiindole derivatives were selected and evaluated at different stages of the life cycle of Leishmania braziliensis parasites, responsible for cutaneous leishmaniasis in South America. Among them, the 8-ethyl-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-3,4-dihydro-1H-spiro[indoline-3,2′-quinolin]-2-one called JS87 was able to inhibit the growth of promastigotes without affecting the mammalian cells viability, and to decrease the number of intracellular amastigotes of L. braziliensis. This spiro compound was found to act through the alteration of parasite internal regulation by disrupting the regulatory volume decrease (RVD), and to affect the sterol biosynthetic pathway at level of squalene epoxidase (SE) enzyme. These results revealed that the spiro annulation between quinoline and oxindole scaffolds enhances the anti-leishmanial activity, and could assist in the development of potent quinoline-oxindole hybrids against Leishmania braziliensis, the main etiol. agent of cutaneous leishmaniasis in South America.

Experimental Parasitology published new progress about Apoptosis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Negri, Laisa Bonafim published the artcilePhotobiomodulation combined with photodynamic therapy using ruthenium phthalocyanine complexes in A375 melanoma cells: Effects of nitric oxide generation and ATP production, Application of Phthalonitrile, the main research area is ruthenium phthalocyanine nitric oxide ATP photodynamic therapy melanoma photobiomodulation; Light irradiation therapy; Metal-based drug; Nitrosyl ruthenium-phthalocyanine complex; Photobiomodulation.

Light irradiation has been used in clin. therapy for several decades. In this context, photobiomodulation (PBM) modulates signaling pathways via ROS, ATP, Ca2+, while photodynamic therapy (PDT) generates reactive oxygen species by excitation of a photosensitizer. NO generation could be an important tool when combined with both kinds of light therapy. By using a metal-based compound, we found that PBM combined with PDT could be a beneficial cancer treatment option. This paper used two types of ruthenium compounds, ([Ru(Pc)], Pc = phthalocyanine) and trans-[Ru(NO)(NO2)(Pc)]. The UV-vis spectra of both complexes displayed a band in the 660 nm region. In the case of 0.5 μM trans-[Ru(NO)(NO2)(Pc)], light irradiation at the Q-band reduced the percentage of viable human melanoma (A375) cells to around 50% as compared to [Ru(Pc)]. We hypothesized that these results were due to a synergistic effect between singlet oxygen and nitric oxide. Similar experiments performed with PDT (660 nm) combined with PBM (850 nm) induced more photocytotoxicity using both [Ru(Pc)] and trans-[Ru(NO)(NO2)(Pc)]. This was interpreted as PBM increasing cell metabolism (ATP production) and the consequent higher uptake of the ruthenium phthalocyanine compounds and more efficient apoptosis. The use of metal-based photosensitizers combined with light therapy may represent an advance in the field of photodynamic therapy.

Journal of Photochemistry and Photobiology, B: Biology published new progress about Apoptosis. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vidyacharan, Shinde published the artcileContinuous-Flow Visible Light Organophotocatalysis for Direct Arylation of 2H-Indazoles: Fast Access to Drug Molecules, COA of Formula: C7H6N2, the main research area is aryldiazonium indazole arylation visible light continuous flow; arylindazole regioselective preparation; visible light arylation promotor; continuous flow micro reaction technol; C−H activation; drug synthesis; flow chemistry; organocatalysis; photocatalysis.

A continuous-flow homogeneous photocatalytic method has been devised for the direct arylation of 2H-indazoles. This visible-light-promoted approach directly accesses a wide range of structurally diverse C3-arylated scaffolds of biol. interest in a fast (1 min), single-step reaction by using eosin Y as an organophotocatalyst. Furthermore, a microreactor technol. is also employed for the fast synthesis of liver X receptor inhibitor drugs with very good yields under metal-free conditions, whereas the reported methods required multiple steps and much longer reaction times (18-24 h).

ChemSusChem published new progress about Arylation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Yamei published the artcileSilica supported potassium oxide catalyst for dehydration of 2-picolinamide to form 2-cyanopyridine, Synthetic Route of 100-70-9, the main research area is picolinamide cyanopyridine silica potassium oxide catalyst dehydration.

The dehydration of 2-picolinamide to produce 2-cyanopyridine was investigated thoroughly using silica supported potassium oxide as a heterogeneous catalyst. Both large sp. surface area and pore size of SiO2 (B) contributed to the favorable catalytic performance for the synthesis of 2-CP. In addition, the yield of 2-CP showed the linear relationship with the amounts of medium basicity of the catalysts, demonstrating that medium basic sites were the active sites of silica supported potassium oxide catalysts. The catalysts were further characterized by XRD and FT-IR to clarify the active species. The results indicated the Si-O-K group produced by the reaction of K2CO3 with Si-OH was the active species, which was further evidenced by the adjustment of the amount of Si-OH by silylation and hydroxylation procedure.

Chinese Chemical Letters published new progress about Catalysis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kalita, Gauravjyoti D. published the artcileBimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure: enhanced catalytic activity of Pd(core)-Au(shell) over Au(core)-Pd(shell), Recommanded Product: Picolinonitrile, the main research area is gold palladium nanoparticle silica coreshell structure catalytic activity.

A facile ligand-assisted approach of synthesizing bimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure is presented. Maneuvering the addition sequence of metal salts, both Aucore-Pdshell (Au@Pd-SiO2) and Pdcore-Aushell (Pd@Au-SiO2) nanoparticles were synthesized. The structures and compositions of the core-shell materials were confirmed by probe-corrected HRTEM, TEM-EDX mapping, EDS line scanning, XPS, PXRD, BET, FE-SEM-EDX and ICP anal. The synergistic potentials of the core-shell materials were evaluated for two important reactions viz. hydrogenation of nitroarenes to anilines and hydration of nitriles to amides. In fact, in both the reactions, the Au-Pd materials exhibited superior performance over monometallic Au or Pd counterparts. Notably, among the two bimetallic materials, the one with Pdcore-Aushell structure displayed superior activity over the Aucore-Pdshell structure which could be attributed to the higher stability and uniform Au-Pd bimetallic interfaces in the former compared to the latter. Apart from enhanced synergism, high chemoselectivity in hydrogenation, wide functional group tolerance, high recyclability, etc. are other advantages of our system. A kinetic study has also been performed for the nitrile hydration reaction which demonstrates first order kinetics. Evaluation of rate constants along with a brief investigation on the Hammett parameters has also been presented.

Nanoscale Advances published new progress about Catalysis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Yu published the artcileRoom-temperature conversion of CO2 into quinazoline-2,4(1H,3H)-dione using deep eutectic solvents at atmospheric pressure with high efficiency, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is carbon dioxide quinazoline dione DES pressure high efficiency temperature.

Highly efficient and sustainable conversion of CO2 into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure is challenging. Deep eutectic solvents (DESs) are considered as the green solvents of the 21st century, which are also designable with high tunability and high atom efficiency. Here, DESs are for the first time used to catalyze the CO2 conversion into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure with high efficiency and nearly 100% yield. This work provides a sustainable way for the efficient conversion of CO2 into quinazoline-2,4(1H,3H)-dione by DESs at room temperature and atm. pressure.

Reaction Chemistry & Engineering published new progress about Catalysis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chan, Chieh-Kai published the artcileEnvironmentally Friendly Nafion-Catalyzed Synthesis of Substituted 2-Ethyl-3-Methylquinolines from Aniline and Propionaldehyde under Microwave Irradiation, HPLC of Formula: 1885-29-6, the main research area is nafion quinoline environmentally microwave irradiation cyclization.

Herein, we report a facile synthetic methodol. for the preparation of 2,3-dialkylquinolines from anilines and propionaldehydes. This cyclization involved environmentally friendly Nafion NR50 as an acidic catalyst with microwave irradiation as the heating source. A series of substituted 2-ethyl-3-methylquinolines were prepared from various anilines and propionaldehyde derivatives through this protocol with good to excellent yields. Some new chem. structures were confirmed by X-ray single-crystal diffraction anal. and the related data were provided. The plausible reaction mechanism studies are also discussed.

Catalysts published new progress about Catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Linbing published the artcileConversion of chenodeoxycholic acid to cholic acid by human CYP8B1, Related Products of nitriles-buliding-blocks, the main research area is chenodeoxycholic cholic acid human CYPB; S. pombe; bile acid; cytochrome P450; fission yeast; liver; steroid hydroxylation.

The human cytochrome P 450 enzyme CYP8B1 is a crucial regulator of the balance of cholic acid (CA) and chenodeoxycholic acid (CDCA) in the liver. It was previously shown to catalyze the conversion of 7α-hydroxycholest-4-en-3-one, a CDCA precursor, to 7α,12α-dihydroxycholest-4-en-3-one, which is an intermediate of CA biosynthesis. In this study we demonstrate that CYP8B1 can also convert CDCA itself to CA. We also show that five derivatives of luciferin are metabolized by CYP8B1 and established a rapid and convenient inhibitor test system. In this way we were able to identify four new CYP8B1 inhibitors, which are aminobenzotriazole, exemestane, ketoconazole and letrozole.

Biological Chemistry published new progress about Catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Revuelta-Maza, Miguel A. published the artcileSynthesis and Aggregation Studies of Functional Binaphthyl-Bridged Chiral Phthalocyanines, HPLC of Formula: 91-15-6, the main research area is zinc phthalocyanine chiral complex preparation CD spectra fluorescence.

We describe the preparation of a battery of chiral Zn(II) phthalocyanines with an AABB substitution pattern through cross-condensation of different chiral, binaphthyloxy-linked bisphthalonitriles and (non)functionalized single phthalonitriles. All the compounds are endowed with reactive groups (halogen and/or ethynyl moieties) that will allow us to prepare customized amphiphilic phthalocyanines. Preliminary self-assembly studies in solution have been performed by UV-vis and CD experiments

Organic Letters published new progress about Chirality. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khajeh Dangolani, Soheila published the artcileImmobilized palladium nanoparticles on a cyclodextrin-polyurethane nanosponge (Pd-CD-PU-NS): An efficient catalyst for cyanation reaction in aqueous media, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is palladium nanoparticle cyclodextrin polyurethane nanosponge catalyst cyanation reaction.

Immobilized palladium nanoparticles on a cyclodextrin-polyurethane nanosponge (Pd-CD-PU-NS) were found to be an efficient heterogeneous catalyst in the cyanation reaction of aryl halides in aqueous media. This catalyst system is containing palladium nanoparticles with a size of � nm. Moreover, the CD-PU-NS support formed microsphere-shaped structures with a size of �00-200 nm. The TEM images show that Pd nanoparticles were formed in near spherical shape morphol. and were immobilized in the structure of the CD-PU-NS support. Under our optimized reaction conditions, aryl cyanides were obtained in high yields in the presence of the Pd-CD-PU-NS catalyst. Our results demonstrated that the Pd-CD-PU-NS catalyst is highly effective in the cyanation reaction in aqueous media. Furthermore, the catalyst could be simply extracted from the reaction mixture, providing an efficient methodol. for the synthesis of aryl cyanides. The Pd-CD-PU-NS catalyst could be recycled four times with almost consistent catalytic efficiency.

Inorganica Chimica Acta published new progress about Cyanation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts