Tag: M.W=0-100

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 151-18-8, name is 3-Aminopropanenitrile, A new synthetic method of this compound is introduced below., name: 3-Aminopropanenitrile

oBromonium iodobenzene(4.0 g, 14.1 mmol) in dimethylsulfoxide (40 mL) was added 3-aminopropionitrile(1.5 mL, 20 mmol), cuprous iodide (2.8 g, 15 mmol), cesium carbonate (7.0 g, 21.5 mmol) and N, N-dimethylglycine(1.5 g, 14 mmol), reacted at 70 C for 5 hours, quenched with water (40 mL), extracted with dichloromethane (40 mL x 3), dried over anhydrous sodium sulfate (Eluent: PE / EtOAc (v / v) = 2/1) to give 3.0 g of a pale yellow oil, and the residue was subjected to column chromatography , Yield: 94%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Liu, Bing; Huang, Jiuzhong; Zhang, Yingjun; Xue, Yaping; Xing, Wei; Xu, Juan; Wu, Zuping; Yu, Tianxi; (106 pag.)CN106432246; (2017); A;,
Nitrile – Wikipedia,
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Application of 630-18-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 630-18-2, name is Pivalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of nitrile (50 mmol), NaN3 (65 mmol), and Et3N¡¤HCl (150 mmol) in toluene (100 mL) was stirred at 110 C for 17-30 h (2b, 2f and 2l for 24 h; 2c and 2d for 17 h; 2e and 2j for 30 h). After cooling to r.t., the mixture was extracted with H2O (100 mL). To the aqueous layer, 36% HCl was added dropwise to acidic pH. After filtration, the solid was washed with water and dried under reduced pressure to give the expected tetrazole 2. The corresponding physical and spectroscopic data for tetrazoles 2 are detailed below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pivalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Behloul, Cherif; Bouchelouche, Kenza; Hadji, Yasmine; Benseghir, Saadia; Guijarro, David; Najera, Carmen; Yus, Miguel; Synthesis; vol. 48; 15; (2016); p. 2455 – 2460;,
Nitrile – Wikipedia,
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These common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Oxobutanenitrile

General procedure: 3-Acetyl-2-aminothiophene Derivatives; General Procedure Carbonyl compound (0.025 mol) was added to freshly prepared cya-noacetone (0.03 mol) in either MeOH or EtOH (40 mL). Sublimed sul-fur S8 (0.03 mol) and piperidine (0.03 mol) were added and the mix-ture was stirred and heated to 55-65 C for 24 h. Ice was then addedand the formed precipitate was filtered under vacuum and washedwith water. The obtained solid was crystallised from a suitable sol-vent, with the exception of 4g and 4j, which were collected directlywithout further purification.

The synthetic route of 3-Oxobutanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Abdelwahab, Ahmed B.; Hanna, Atef G.; Kirsch, Gilbert; Synthesis; vol. 48; 17; (2016); p. 2881 – 2888;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 20249-16-5, name is 3-Oxocyclobutanecarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20249-16-5, HPLC of Formula: C5H5NO

NaBH4 (2.4 g, 63 45 mmol, 0 50 eq.) was added slowly to a -70C solution of 3-oxocyclobutane-l-carbonitrile (12 g, 126.18 mmol, 1.00 eq., prepared according example 33, step 1) in THF (100 mL) and water (5 mL). The resulting solution was stirred for 1 hour at -70C in a liquid nitrogen bath. The reaction was then quenched by the addition of 50 mL of water/ice. The resulting solution was extracted with ethyl acetate (3×100 mL) and the organic layers combined. The resulting mixture was washed with brine (3×50 mL), dried over anhydrous sodium sulfate and concentrated under vacuum to give 8.13 g (66%) of 3-hydroxycyclobutane-l-carbonitrile as colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Oxocyclobutanecarbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; BASTOS, Cecilia, M.; MUNOZ, Benito; TAIT, Bradley; (178 pag.)WO2016/115090; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 6330-25-2, name is 2-Cyano-N-methyl-acetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6330-25-2, Recommanded Product: 6330-25-2

General procedure: Sodium metal (46 mg, 2.0 mmol) was placed in a flask, equipped with reflux condenser and calcium chloride tube,and dissolved in absolute ethanol (4-5 ml). The obtained solution was treated with a mixture of the appropriate 3-carbamoylchromone 3 (1 mmol) and cyanoacetamide(2 mmol) and refluxed with stirring for 2 h. After coolingthe reaction mixture to room temperature, regardless of the presence of precipitate, the mixture was stirred and neutralized with 1 N HCl. The obtained fine crystalline precipitate was filtered off, washed with ethanol, dried, and recrystallized from a 1:3 mixture of DMF-EtOH.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Cyano-N-methyl-acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kornev, Mikhail Yu.; Moshkin, Vladimir S.; Sosnovskikh, Vyacheslav Ya.; Chemistry of Heterocyclic Compounds; vol. 51; 7; (2015); p. 688 – 690; Khim. Geterotsikl. Soedin.; vol. 51; 7; (2015); p. 688 – 690,3;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 6011-14-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6011-14-9 as follows.

4-Acetylbenzoic acid (10 g, 0.061 mol) was added to a 500 mL eggplant-shaped bottle. Add N,N-dimethylformamide (150 mL), triethylamine (18 mL, 13.5 g), HOBt (9.7 g, 0.071 mol), and stirred at room temperature for 10 min. After the solid was substantially dissolved, EDCI (13.8 g, 0.071 mol) was added and stirring was continued for 1 h. Aminoacetonitrile hydrochloride (6.16 g, 0.067 mol) was added to react at room temperature, and the reaction was followed by thin layer chromatography (TLC). After 4 h, TLC showed the reaction was completed. A large amount of solid is formed, and the reaction solution is poured into dilute hydrochloric acid (concentration: 12 to 18% by weight), stirred for 30 minutes, and the solid is precipitated, suction filtered, washed with water, and dried to obtain 4-acetyl-N-(cyanomethyl)benzoamide 11.7 g, yield 95%.

According to the analysis of related databases, 6011-14-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fushun Daheng Chemical Co., Ltd.; Shenyang Jinjiuqi Technology Co., Ltd.; Yu Kai; Zhao Zhiwei; Qu Yuanyuan; Wang Wei; Wang Han; (25 pag.)CN108707119; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6011-14-9, name is 2-Aminoacetonitrile hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Aminoacetonitrile hydrochloride

To 2g (5.3mmol) C4 was added 4.42 ml (32mmol) triethylamine, 0.98g (10.6mmol) aminoacetonitrile hydrochloride, 1.22g (6.6mmol) EDCI, and 860 ml (6.6mmol) HOBT. It was dissolved in 20mL DMF. After reacting at room temperature overnight, concentrate to dry, by adding dichloromethane, with saturated sodium bicarbonate solution, salt water after washing, concentrating, methanol used for recrystallization to obtain the yellow solid, yield 90%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; China Pharmaceutical University; Wang, Peng; Gu, Yueqing; Huang, Jinxin; (9 pag.)(2016);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2469-99-0, name is 3-Oxobutanenitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 2469-99-0

General procedure: 3-Acetyl-2-aminothiophene Derivatives; General Procedure Carbonyl compound (0.025 mol) was added to freshly prepared cya-noacetone (0.03 mol) in either MeOH or EtOH (40 mL). Sublimed sul-fur S8 (0.03 mol) and piperidine (0.03 mol) were added and the mix-ture was stirred and heated to 55-65 C for 24 h. Ice was then addedand the formed precipitate was filtered under vacuum and washedwith water. The obtained solid was crystallised from a suitable sol-vent, with the exception of 4g and 4j, which were collected directlywithout further purification.

According to the analysis of related databases, 2469-99-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Abdelwahab, Ahmed B.; Hanna, Atef G.; Kirsch, Gilbert; Synthesis; vol. 48; 17; (2016); p. 2881 – 2888;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 6011-14-9, name is 2-Aminoacetonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6011-14-9, name: 2-Aminoacetonitrile hydrochloride

The coupling of an aminonitrile to a carboxylic acid and subsequentBoc-deprotection is described and is referred to as General Method 6. To a solution ofCompound 101-N (180 mg, 0.15 mmol), aminoacetonitrile hydrochloride (31 mg, 0.33 mmol) and DIPEA (38 mg, 0.29 mmol) in DCM/DMF (3 mL, 2:1) at 0C, HATU (56 mg, 0.15 mmol) was added while stirring. The resulting mixture was stirred at room temperature for lh. Most DCM was removed under reduced pressure and the residue was poured into water (10 mL),which was extracted with EtOAc (20 mL x 3). The combined organic layers were washed with brine (50 mL), dried over Na2504, concentrated to the residue, which was purified by flash chromatography column to afford Compound 101-0 (140 mg, 76%) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Aminoacetonitrile hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; RQX PHARMACEUTICALS, INC.; GENENTECH, INC.; CHEN, Yongsheng; SMITH, Peter Andrew; ROBERTS, Tucker Curran; HIGUCHI, Robert I.; PARASELLI, Prasuna; KOEHLER, Michael F. T.; SCHWARZ, Jacob Bradley; CRAWFORD, James John; LY, Cuong Q.; HANAN, Emily J.; HU, Huiyong; YU, Zhiyong; (424 pag.)WO2017/84630; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 6330-25-2, A common heterocyclic compound, 6330-25-2, name is 2-Cyano-N-methyl-acetamide, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 1-methyl-3-cyano-4-methyl-6-hydroxy-2-pyridone required as intermediate may be prepared, for instance, by condensation of methyl acetoacetate with N-methyl-cyanoacetamide in an aqueous alkaline medium at room temperature. It constitutes a colorless powder melting at 280 to 282.

The synthetic route of 6330-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cassella Farbwerke Mainkur Aktiengesellschaft; US3957749; (1976); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts