Tag: 200-300

In 2022,Bawden, Joseph C.; Francis, Paul S.; DiLuzio, Stephen; Hayne, David J.; Doeven, Egan H.; Truong, Johnny; Alexander, Richard; Henderson, Luke C.; Gomez, Daniel E.; Massi, Massimiliano; Armstrong, Blake I.; Draper, Felicity A.; Bernhard, Stefan; Connell, Timothy U. published an article in Journal of the American Chemical Society. The title of the article was 《Reinterpreting the Fate of Iridium(III) Photocatalysts-Screening a Combinatorial Library to Explore Light-Driven Side-Reactions》.Electric Literature of C7H3BrFN The author mentioned the following in the article:

Photoredox catalysts are primarily selected based on ground and excited state properties, but their activity is also intrinsically tied to the nature of their reduced (or oxidized) intermediates. Catalyst reactivity often necessitates an inherent instability, thus these intermediates represent a mechanistic turning point that affords either product formation or side-reactions. In this work, we explore the scope of a previously demonstrated side-reaction that partially saturates one pyridine ring of the ancillary ligand in heteroleptic iridium(III) complexes. Using high-throughput synthesis and screening under photochem. conditions, we identified different chem. pathways, ultimately governed by ligand composition The ancillary ligand was the key factor that determined photochem. stability. Following photoinitiated electron transfer from a sacrificial tertiary amine, the reduced intermediate of complexes containing 1,10-phenanthroline derivatives exhibited long-term stability. In contrast, complexes containing 2,2′-bipyridines were highly susceptible to hydrogen atom transfer and ancillary ligand modification. Detailed characterization of selected complexes before and after transformation showed differing effects on the ground and excited state reduction potentials dependent on the nature of the cyclometalating ligands and excited states. The implications of catalyst stability and reactivity in chem. synthesis was demonstrated in a model photoredox reaction. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Electric Literature of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Electric Literature of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Haoyu; Liu, Yuliang; Chiba, Shunsuke published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Anti-Markovnikov hydroarylation of alkenes via polysulfide anion photocatalysis》.Formula: C7H3BrFN The article contains the following contents:

A protocol for anti-Markovnikov hydroarylation of alkenes, e.g., 2,3-dihydrofuran with aryl halides ArX (Ar = (4-CO2CH3)C6H4, 2-naphthyl, 5-cyanothiophen-2-yl, etc.; X = Br, Cl) has been developed using polysulfide anions as photocatalysts in the presence of the Hantzsch ester and water under irradiation with visible light. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Formula: C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Cobalt-Catalyzed Cross-Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Lutter, Ferdinand H.; Grokenberger, Lucie; Spiess, Philipp; Hammann, Jeffrey M.; Karaghiosoff, Konstantin; Knochel, Paul. HPLC of Formula: 105942-08-3 The article mentions the following:

A combination of 10% CoCl2 and 20% 2,2′-bipyridine ligands enables cross-coupling of functionalized primary and secondary alkylzinc reagents RZnY (R = 3-phenylpropyl, 3-(2,5-dimethyl-1H-pyrrol-1-yl)propyl, cyclopropyl, etc.; Y = Cl, Br) with various (hetero)aryl halides R1X (R1 = 5-cyanopyridin-2-yl, quinolin-2-yl, pyrimidin-2-yl, etc.; X = Cl, Br). Couplings with 1,3- and 1,4-substituted cycloalkylzinc reagents R2ZnI (R2 = 3-methylcyclohexyl, 4-(1H-pyrrol-1-yl)cyclohexyl, (4R,4aS,6R,8aR)-4,4a-dimethyl-6-(propan-2-yl)-decahydronaphthalen-2-yl, etc.) proceeded diastereoselectively leading to functionalized heterocycles R1R2 with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides R3CCBr (R3 = Ph, tris(propan-2-yl)silyl) react with primary and secondary alkylzinc reagents RZnY (R = 2-(1,3-dioxan-2-yl)ethyl, 4-phenylcyclohexyl; Y = Cl, I) providing the alkylated alkynes RCCR3. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3HPLC of Formula: 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.HPLC of Formula: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Hendrick, Charles E.; Bitting, Katie J.; Cho, Seoyoung; Wang, Qiu published 《Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation》.Journal of the American Chemical Society published the findings.Product Details of 105942-08-3 The information in the text is summarized as follows:

Arene amination is achieved by site-selective C-H zincation followed by copper-catalyzed coupling with O-benzoylhydroxylamines under mild conditions. Key to this success is ortho-zincation mediated by lithium amidodiethylzincate base that is effective for a wide range of arenes, including nonactivated arenes bearing simple functionalities such as fluoride, chloride, ester, amide, ether, nitrile, and trifluoromethyl groups as well as heteroarenes including indole, thiophene, pyridine, and isoquinoline. An analogous C-H azidation is also accomplished using azidoiodinane for direct introduction of a useful azide group onto a broad scope of arenes and heteroarenes. These new transformations offer rapid access to valuable and diverse chem. space of aminoarenes. Their broad applications in organic synthesis and drug discovery are demonstrated in the synthesis of novel analogs of natural product (-)-nicotine and antidepressant sertraline by late-stage amination and azidation reactions. After reading the article, we found that the author used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Protective effects of piper betel phenol, hydroxychavicol and its derivatives against rotenone induced neurotoxicity: synthesis, in vitro and in vivo efficacy studies》 were Ghanta, Venkata Rao; Pasula, Aparna; Pindiprolu, Sai Kiran S. S.; Krishnamurthy, Praveen T.; Ravi, Chandran J. K.; Raman, Balamurali. And the article was published in World Journal of Pharmaceutical Research in 2019. Quality Control of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

Hydroxychavicol or 4-Allylpyrocatechol (4-APC) is a Piper betel phenol, reported to modulate vital pathways involved in inflammation and oxidative stress. However, the potential neuro protective benefits of 4APC against neurodegeneration, where similar pathways are involved was not reported and hence 4APC and its derivatives (3a – 3j) were evaluated for their possible neuroprotective activity against rotenone induced neurotoxicity. In the present study 4-allyl pyrocatechol (APC) and its derivatives (3a – 3j) were synthesized via heck coupling with aryl bromides and evaluated for their possible in vitro and in vivo neuroprotective activity against rotenone induced neurotoxicity in SH-SY5Y cell lines and in Swiss albino mice, resp. In the in vitro studies, among the tested compounds, the 4APC and its derivative, 3c, have shown significant protection against rotenone induced cytotoxicity. In mice, these 2 mols. significantly prevent the rotenone (3 mg/kg, s.c.) induced changes in grip strength, locomotor activity and oxidative & inflammatory stress markers at a tested oral dose of 20/mg/kg. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Quality Control of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Quality Control of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Hammann, Jeffrey M.; Lutter, Ferdinand H.; Haas, Diana; Knochel, Paul published 《A Robust and Broadly Applicable Cobalt-Catalyzed Cross-Coupling of Functionalized Bench-Stable Organozinc Pivalates with Unsaturated Halides》.Angewandte Chemie, International Edition published the findings.Name: 4-Bromo-2-fluorobenzonitrile The information in the text is summarized as follows:

We report a robust and broadly applicable CoCl2-catalyzed cross-coupling between functionalized aryl and heteroaryl zinc pivalates and various electron-poor aryl and heteroaryl halides (X=Cl, Br, I). Couplings with (E)- or (Z)-bromo- or iodo-alkenes proceed with retention of configuration. Also, alkynyl bromides react with arylzinc pivalates providing arylated alkynes. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Name: 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2008,Rapid Communications in Mass Spectrometry included an article by Barrero-Moreno, Josefa M.; Tirendi, Salvatore; Reniero, Fabiano; Giordano, Giuseppe; Kotzias, Dimitrios. Recommanded Product: 2,3-Diisobutyl-2,3-dimethylsuccinonitrile. The article was titled 《Identification of 2,3-dimethyl-2,3-diisobutyl succinonitrile in laser printer emissions》. The information in the text is summarized as follows:

2,3-Dimethyl-2,3-diisobutyl succinonitrile was identified as the main volatile organic compound (>90%) emitted from laser printers during printing. Experiments were conducted in a large environmental chamber (30 m3) where printers were placed and working to simulate actual office setting conditions. Air, collected on Tenax TA adsorbent cartridges near the printers, was analyzed by thermal desorption gas chromatog.-mass spectrometry. Determined compounds are discussed. Addnl. data obtained by NMR, Fourier transform IR spectroscopy, and liquid chromatog.-tandem mass spectrometry (LC-MS/MS) supported the proposed structure (having no reported Chem. Abstracts Service number), as 2,3-dimethyl-2,3-diisobutyl succinonitrile. This compound is a byproduct of the thermal decomposition of 2,2′-azobis(2,4-di-Me valeronitrile), a com. available free radical polymerization initiator used in polymerization processes during toner manufacturing By headspace GC/MS, 15 toners used in black and white and color printers were examined; 6 contained 2,3-dimethyl-2,3-diisobutyl succinonitrile, which was also detected in processed paper. The experimental process involved the reaction of 2,3-Diisobutyl-2,3-dimethylsuccinonitrile(cas: 80822-82-8Recommanded Product: 2,3-Diisobutyl-2,3-dimethylsuccinonitrile)

2,3-Diisobutyl-2,3-dimethylsuccinonitrile(cas: 80822-82-8) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Recommanded Product: 2,3-Diisobutyl-2,3-dimethylsuccinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reddy, G. Jagath; Latha, D.; Thirupathaiah, C.; Rao, K. Srinivasa published an article in Organic Preparations and Procedures International. The title of the article was 《An efficient one step conversion of 3-formylchromones into 3-cyanochromones》.Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The author mentioned the following in the article:

A one step conversion of 3-formylchromones into 3-cyanochromones. Substituted 3-formylchromones were heated with hydroxylamine hydrochloride in refluxing acetonitrile in the presence of sodium iodide to give 3-cyanochromones in good yields. The results came from multiple reactions, including the reaction of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Safety of 4-Bromo-2-fluorobenzonitrileIn 2017 ,《Triplet decay-induced negative temperature dependence of the transient photoluminescence decay of thermally activated delayed fluorescence emitter》 was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. The article was written by Wei, Xiaofang; Chen, Yongzhen; Duan, Ruihong; Liu, Jianjun; Wang, Ruifang; Liu, Yanwei; Li, Zhiyi; Yi, Yuanping; Yamada-Takamura, Yukiko; Wang, Pengfei; Wang, Ying. The article contains the following contents:

The photophys. properties of three TX-based D-A isomers (TXO-PhCz1, TXO-PhCz3, and TXO-PhCz4) with a PhCz donor at different substitution positions of Ph group on a TXO unit were studied. The substitution position of the PhCz unit significantly impacts the photophys. properties of these isomers. TXO-PhCz1 exhibits a very weak emission in both undoped and doped films, while TXO-PhCz3 and TXO-PhCz4 exhibit a strong emission with the requisite properties for TADF emitters, including a small ΔEST and transient PL decay curves with a prompt and delayed fluorescent component. TXO-PhCz4 exhibits a much stronger orbital coupling than TXO-PhCz3 and then the phosphorescent emission causes the inverse temperature dependence of the transient PL decay, which is contrary to that of TXO-PhCz3 and other TADF emitters. TXO-PhCz4 exhibits a small ΔEST of 23 meV and a short decay time of 14 μs at room temperature, which are much smaller and shorter than those of TXO-PhCz3. Multilayer OLEDs based on TXO-PhCz4 exhibit a very low-efficiency roll-off with a maximum current efficiency of 49.2 cd A-1, a maximum power efficiency of 47.7 lm W-1, and a maximum EQE of 16.3%. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Safety of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Safety of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Category: nitriles-buliding-blocksOn November 30, 2012 ,《Isothermal high-pressure studies of 4-cyano-3-fluorophenyl 4-butylbenzoate dynamics near room temperature》 appeared in Physical Review E: Statistical, Nonlinear, and Soft Matter Physics. The author of the article were Rozwadowski, Tomasz; Massalska-Arodz, Maria; Wojnarowska, Zaneta; Paluch, Marian; Juszynska, Ewa; Krawczyk, Jan. The article conveys some information:

For 4-cyano-3-fluorophenyl 4-butylbenzoate, a glass former giving glass of nematic phase at ambient pressure and after rapid pressurizing, isothermal studies of complex dielec. permittivity vs. pressure were performed near room temperature In the previous isobaric experiment, on cooling the nematic phase two super-Arrhenius α relaxations, ascribed to the reorientations of mols. around short axes (main process) and precession of long mol. axes, and β relaxation related to intramol. motions were found. In the present isothermal experiments nematic-smectic phase transition was induced by increasing pressure. Linear pressure dependence of the logarithm of the dielec. relaxation time gives activation volume of ∼70 cm3/mol for liquid crystalline phases and 50 cm3/mol for the isotropic phase. The time-temperature-pressure superposition principle for the α-relaxation process is valid (i.e., a single master curve can be obtained by superpositioning dielec. loss curves measured at various temperatures and pressures). In addition to this study using 4-Cyano-3-fluorophenyl 4-butylbenzoate, there are many other studies that have used 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5Category: nitriles-buliding-blocks) was used in this study.

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts