Tag: 100-200

The author of 《Novel phthalimide based analogues: Design, synthesis, biological evaluation, and molecular docking studies》 were Othman, Ismail M. M.; Gad-Elkareem, Mohamed A. M.; El-Naggar, Mohamed; Nossier, Eman S.; Amr, Abd El-Galil E.. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. SDS of cas: 614-16-4 The author mentioned the following in the article:

Pyrazolylphthalimide derivative I was synthesized and reacted with different reagents to afford the target imidazopyrazoles II, III, and IV, pyrazolopyrimidines V (R = NH2, R1 = CN, R2 = SMe; R = H, R1 = COPh, R2 = NH2; R = H, R1 = CN, R2 = NH2) and pyrazolotriazines VI (R3 = CN, R4 = NH2; R3 = CO2Et, R4 = Me) containing phthalimide moiety. The prepared compounds were established by different spectral data and elemental analyses. Addnl., all synthesized derivatives were screened for their antibacterial activity against four types of Gram + ve and Gram-ve strains, and for antifungal activity against two fungi micro-organisms by well diffusion method. Moreover, the antiproliferative activity was tested for all compounds against human liver (HepG-2) cell line in comparison with the reference vinblastine. Moreover, drug-likeness and toxicity risk parameters of the newly synthesized compounds were calculated using in-silico studies. The data from structure-activity relationship (SAR) anal. suggested that phthalimide derivative bearing 3-aminopyrazolone moiety, illustrated the best antimicrobial and antitumor activities and might be considered as a lead for further optimization. To investigate the mechanism of the antimicrobial and anticancer activities, enzymic assay and mol. docking studies were carried out on E. coli topoisomerase II DNA gyrase B and VEGFR-2 enzymes. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4SDS of cas: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.SDS of cas: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Eldehna, Wagdy M.; Salem, Rofaida; Elsayed, Zainab M.; Al-Warhi, Tarfah; Knany, Hamada R.; Ayyad, Rezk R.; Traiki, Thamer Bin; Abdulla, Maha-Hamadien; Ahmad, Rehan; Abdel-Aziz, Hatem A.; El-Haggar, Radwan published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021. The article was titled 《Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer》.Application In Synthesis of 4-Cyanobenzyl bromide The article contains the following contents:

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates ( and ) was designed and synthesized. The anticancer activity for compounds (, and ) was measured against NCI-55 human cancer cell lines. Compound was the most efficient, and thus subjected to the five-dose screen where it showed excellent broad activity against almost all tested cancer subpanels. Furthermore, all conjugates ( and ) showed a good anti-proliferative activity towards colorectal cancer SW-620 and HT-29 cell lines, with an excellent inhibitory effect for compounds and (IC50 = 8.7 and 9.4μM (), and 6.5 and 9.8μM for (), resp.). Both compounds displayed selective cytotoxicity with good safety profile. In addition, both compounds provoked apoptosis in a dose dependent manner in SW-620 cells. Also, they significantly inhibited the anti-apoptotic Bcl2 protein expression and increased the cleaved PARP level that resulted in SW-620 cells apoptosis. After reading the article, we found that the author used 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Application In Synthesis of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. These research results belong to Al-Rashood, Sara T.; Hamed, Ahmed R.; Hassan, Ghada S.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Alharbi, Amal; Al-Sanea, Mohammad M.; Eldehna, Wagdy M.. HPLC of Formula: 614-16-4 The article mentions the following:

In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic compounds Interestingly, no much attention has been paid to develop spirooxindole derivatives with dual antioxidant and anticancer activities. In this context, a series of spirooxindoles 6a-p was examined for their anticancer effect towards HepG2 hepatocellular carcinoma and PC-3 prostate cancer cell lines. Spirooxindole 6a was found to be an efficient anti-proliferative agent towards both HepG2 and PC-3 cells (IC50 = 6.9 and 11.8μM, resp.). Afterwards, spirooxindole 6a was assessed for its apoptosis induction potential in HepG2 cells, where its pro-apoptotic impact was approved via the significant elevation in the Bax/Bcl-2 ratio and the expression levels of caspase-3,. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Parent-amido (NH₂) palladium(II) complexes: Synthesis, reactions, and catalytic hydroamination was written by Kim, Youngwon;Park, Soonheum. And the article was included in Comptes Rendus Chimie in 2016.Recommanded Product: 3,3′,3”-Nitrilotripropanenitrile This article mentions the following:

The treatment of [PdL₃(NH₃)](OTf)_n [n = 1; L₃ = (PEt₃)₂(Ph), 2,6-(Cy₂PCH₂)₂C₆H₃; n = 2; L₃ = (dppe)(NH₃)] with NaNH₂ in THF at ambient temperature or -78鎺?afforded the dimeric and monomeric parent-amido palladium(II) complexes anti-[Pd(PEt₃)(Ph)(娓?NH₂)]₂ (1), [Pd(dppe)(娓?NH₂)]₂(OTf)₂ (2), and Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(NH₂) (3), resp. The mol. structures of the amido-bridged (娓?NH₂) dimeric complexes 1 and 2 were determined by single-crystal x-ray crystallog. The monomeric amido complex 3 reacted with trace amounts of water to give a hydroxo complex, Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(OH) (4). Exposing complex 3 to an excess of water resulted in the complete conversion of the complex into two species [Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(OH₂)]⁺ and [Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(NH₃)]⁺. Complex 3 reacted with diphenyliodonium triflate ([Ph₂I]OTf) to give the aniline complex [Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(NH₂Ph)]OTf. The reaction of 3 with phenylacetylene (HC椤氬挵Ph) yielded a palladium(II) acetylenide Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(C椤氬挵Ph) (5), quant., along with the liberation of ammonia. The reaction of 3 with dialkyl acetylenedicarboxylate yielded diastereospecific palladium(II) vinyl derivatives (Z)-[Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(CR:CRNH₂)] (6a,b, R = CO₂Me, CO₂Et). The reaction of complexes 6a and 6b with p-nitrophenol produced Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(OC₆H₄-p-NO₂) (7) and cis-CHR:CR(NH₂), exclusively. Reactions of 3 with either dialkyl maleate cis-(CO₂R)CH=CH(CO₂R) (R = Me, Et) or cis-stilbene cis-CHPh:CHPh did not result in any addition product. Instead, isomerization of the cis-isomers to the trans-isomers occurred in the presence of catalytic amounts of 3. Complex 3 reacted with a stoichiometric amount of acrylonitrile CH₂:CHCN to generate a metastable insertion product, Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(CH(CN)CH₂NH₂). On the other hand, the reaction of 3 with an excess of acrylonitrile slowly produced polymeric species of acrylonitrile. The catalytic hydroamination of olefins with NH₃ was examined in the presence of Pd(2,6-(Cy₂PCH₂)₂C₆H₃)(OTf), producing a range of hydroaminated products of primary, secondary, and tertiary amines with different molar ratios of more than 99% overall yield. A mechanistic feature for the observed catalytic hydroamination is described with regard to the aminated derivatives of palladium(II). In the experiment, the researchers used many compounds, for example, 3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1Recommanded Product: 3,3′,3”-Nitrilotripropanenitrile).

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Recommanded Product: 3,3′,3”-Nitrilotripropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts