Tag: 100-200

TiO₂/nanoclinoptilolite as an efficient nanocatalyst in the synthesis of substituted 2-aminothiophenes was written by Javadi, Farzad;Tayebee, Reza;Bahramian, Bahram. And the article was included in Applied Organometallic Chemistry in 2017.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile This article mentions the following:

TiO₂/nanoclinoptilolite (TiO₂/NCP) was prepared by the mediation of hexadecyltrimethylammonium (HDTMA) as surfactant and used as an effective heterogeneous nanocatalyst for the preparation of substituted 2-aminothiophenes. The modified HDTMA/NCP was impregnated with titanium(IV) chloride solution followed by calcination at 500 鎺矯 for 20 h. The obtained nanocomposite was characterized using Fourier transform IR spectroscopy, field emission SEM, inductively coupled plasma optical emission spectroscopy and X-ray diffraction. Moreover, the prepared nanocomposite had high stability and recoverability under mild and solvent-free conditions. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The R-C-N bond angle in and nitrile is 180鎺?which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two 锜? bond in the triple bond. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The Cascade Methylation/Cyclization of ortho-Cyanoarylacrylamides with Dicumyl Peroxide was written by Yang, Tao;Xia, Wen-Jin;Zhou, Bin;Xin, Yangchun;Shen, Yuehai;Li, Ya-Min. And the article was included in European Journal of Organic Chemistry in 2019.SDS of cas: 1483-54-1 This article mentions the following:

A radical cascade methylation/cyclization of ortho-cyanoarylacrylamides was developed by utilizing dicumyl peroxide as a methylation reagent. This transformation provides a simple and straight forward approach to methylated quinoline-2,4(1H,3H)-diones, and exhibits a wide substrate scope. Furthermore, this reaction could be readily scaled up. A possible mechanism is also proposed. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1SDS of cas: 1483-54-1).

2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).SDS of cas: 1483-54-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis and Biological Evaluation of 2- and 3-Aminobenzo[b]thiophene Derivatives as Antimitotic Agents and Inhibitors of Tubulin Polymerization was written by Romagnoli, Romeo;Baraldi, Pier Giovanni;Carrion, Maria Dora;Lopez Cara, Carlota;Preti, Delia;Fruttarolo, Francesca;Pavani, Maria Giovanna;Tabrizi, Mojgan Aghazadeh;Tolomeo, Manlio;Grimaudo, Stefania;Di Antonella, Cristina;Balzarini, Jan;Hadfield, John A.;Brancale, Andrea;Hamel, Ernest. And the article was included in Journal of Medicinal Chemistry in 2007.Recommanded Product: 5-Methyl-2-nitrobenzonitrile This article mentions the following:

Two new series of inhibitors of tubulin polymerization based on the 2-amino-3-(3,4,5-trimethoxybenzoyl)benzo[b]thiophene mol. skeleton and its 3-amino positional isomer were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. Although many more 3-amino derivatives have been synthesized so far, the most promising compound in this series was 2-amino-6-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]thiophene, which inhibits cancer cell growth at subnanomolar concentrations and interacts strongly with tubulin by binding to the colchicine site. In the experiment, the researchers used many compounds, for example, 5-Methyl-2-nitrobenzonitrile (cas: 64113-86-6Recommanded Product: 5-Methyl-2-nitrobenzonitrile).

5-Methyl-2-nitrobenzonitrile (cas: 64113-86-6) belongs to nitriles. Nitrile carbon shifts are in the range of 115閳?25 ppm whereas in isonitriles the shifts are around 155閳?65 ppm. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Recommanded Product: 5-Methyl-2-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Studying of porous polymer surface properties changes by energetic heterogeneity function was written by Guskov, V. Yu.;Ganieva, A. G.;Kudasheva, F. Kh.. And the article was included in Sorbtsionnye i Khromatograficheskie Protsessy in 2014.Computed Properties of C9H12N4 This article mentions the following:

In present work we try to detect changes on styrene-divinylbenzene microporous polymer surface by adsorption energy distribution function (heterogeneity function, 锠?. Polymer surface was modified by 0.1-10⁴ ppm of polyethylene glycol, polyethylene glycol adipate and tripropionitrilamine. Heterogeneity function was calculated from the inverse gas chromatog. data. It was determined that function 锠?was capable to detect surface properties variations only at 10³ ppm and above modifier impregnation. If one use the first derivative of 锠? it allows detecting surface properties changes after 0.1-1 ppm modifier impregnation. In the experiment, the researchers used many compounds, for example, 3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1Computed Properties of C9H12N4).

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Computed Properties of C9H12N4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Combinatorial synthesis of chemical building blocks 1. Azomethines was written by Ryabukhin, Sergey V.;Panov, Dmitriy M.;Plaskon, Andrey S.;Chuprina, Alexander;Pipko, Sergey E.;Tolmachev, Andrey A.;Shivanyuk, Alexander N.. And the article was included in Molecular Diversity in 2012.Synthetic Route of C8H8N2S This article mentions the following:

128 Azomethines were synthesized through condensation of carbonyl compounds with various amines in pyridine in the presence of Me₃SiCl as promoter and water scavenger in 58-98% yield. Et₃N was added to reaction mixtures before precipitating the product with H₂O to prevent acid catalyzed hydrolysis of the C:N bond. The scope and limitation of the method are discussed. High yields and a simple setup/workup procedure make this method suitable for the combinatorial synthesis of azomethines, which are suitable as starting materials for high throughput synthesis of various combinatorial libraries. The azomethines synthesized were intermediates in a one-pot combinatorial synthesis of amines and amides. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Synthetic Route of C8H8N2S).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile carbon shifts are in the range of 115閳?25 ppm whereas in isonitriles the shifts are around 155閳?65 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Synthetic Route of C8H8N2S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asymmetric Reduction of Ketones by Phosphoric Acid Derived Catalysts was written by Zhang, Zuhui;Jain, Pankaj;Antilla, Jon C.. And the article was included in Angewandte Chemie, International Edition in 2011.Related Products of 101219-69-6 This article mentions the following:

Asym. reduction of ketones using a phosphoric acid derivative as the precatalyst was reported. Using catecholborane as a reducing agent, chiral secondary alcs. were produced with high levels of enantioselectivities over a resonably broad substrate scope. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Related Products of 101219-69-6).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Related Products of 101219-69-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Redox-Active Reagents for Photocatalytic Generation of the OCF₃ Radical and (Hetero)Aryl C-H Trifluoromethoxylation was written by Zheng, Weijia;Lee, Johnny W.;Morales-Rivera, Cristian A.;Liu, Peng;Ngai, Ming-Yu. And the article was included in Angewandte Chemie, International Edition in 2018.HPLC of Formula: 55406-13-8 This article mentions the following:

The trifluoromethoxy (OCF₃) radical is of great importance in organic chem. Yet, the catalytic and selective generation of this radical at room temperature and pressure remains a longstanding challenge. Herein, the design and development of a redox-active cationic reagent (1) that enables the formation of the OCF₃ radical in a controllable, selective, and catalytic fashion under visible-light photocatalytic conditions is reported. More importantly, the reagent allows catalytic, intermol. C-H trifluoromethoxylation of a broad array of (hetero)arenes and biorelevant compounds Exptl. and computational studies suggest single electron transfer (SET) from excited photoredox catalysts to 1 resulting in exclusive liberation of the OCF₃ radical. Addition of this radical to (hetero)arenes gives trifluoromethoxylated cyclohexadienyl radicals that are oxidized and deprotonated to afford the products of trifluoromethoxylation. In the experiment, the researchers used many compounds, for example, 3-Methylthiophene-2-carbonitrile (cas: 55406-13-8HPLC of Formula: 55406-13-8).

3-Methylthiophene-2-carbonitrile (cas: 55406-13-8) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.HPLC of Formula: 55406-13-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Experimental and Computational Studies on Cp*^CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks was written by Li, Liping;Gao, Hui;Sun, Ming;Zhou, Zhi;Yi, Wei. And the article was included in Organic Letters in 2020.Quality Control of 2-Amino-3-chlorobenzonitrile This article mentions the following:

Described herein is an unusual Cp*CyRh(III)-catalyzed intramol. site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams I (R¹ = H, 9-Me, 7-Cl, etc; R² = Me, Et, Ph, 4-Br-C₆H₄; R³ = H, 2-Me, 3-OMe, etc.)and II (X = CO, PO-Ph; Ar = Ph, 2-Me-C₆H₄, Naph, Py, etc.) with broad substrate/functional group tolerance. Exptl. and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/灏?H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H₂ as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features. In the experiment, the researchers used many compounds, for example, 2-Amino-3-chlorobenzonitrile (cas: 53312-77-9Quality Control of 2-Amino-3-chlorobenzonitrile).

2-Amino-3-chlorobenzonitrile (cas: 53312-77-9) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Quality Control of 2-Amino-3-chlorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pyrazole NNRTIs 3: Optimisation of physicochemical properties was written by Mowbray, Charles E.;Corbau, Romuald;Hawes, Michael;Jones, Lyn H.;Mills, James E.;Perros, Manos;Selby, Matthew D.;Stupple, Paul A.;Webster, Rob;Wood, Anthony. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Reference of 104798-53-0 This article mentions the following:

Our efforts to reduce overall lipophilicity and increase ligand-lipophilicity efficiency (LLE) by modification of the 3- and 5-substituents of pyrazole I, a novel non-nucleoside HIV reverse transcriptase inhibitor (NNRTI) prototype were unsuccessful. In contrast replacement of the substituted benzyl group with corresponding phenylthio or phenoxy groups resulted in marked improvements in potency, ligand efficiency (LE) and LLE. In the experiment, the researchers used many compounds, for example, 2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0Reference of 104798-53-0).

2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Reference of 104798-53-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Piperazine-Grafted Magnetic Reduced Graphene Oxide (Fe₃O₄@rGO-NH) as a Reusable Heterogeneous Catalyst for Gewald Three-Component Reaction was written by Rezaei-Seresht, Esmail;Bakhshi-Noroozi, Morteza;Maleki, Behrooz. And the article was included in Polycyclic Aromatic Compounds in 2021.Application of 70291-62-2 This article mentions the following:

In recent years, interesting phys. and chem. properties of graphene oxide (GO) have led to a great deal of excitement in the chem. One of the most promising results is the use of GO and the functionalized GOs as heterogeneous catalysts in organic synthesis. In this work, GO was functionalized with piperazine (GO-NH), converted to magnetic GO-NH by incorporating Fe₃O₄ particles into GO-NH (Fe₃O₄@rGO-NH), and then reduced with hydrazine hydrate to yield piperazine-grafted magnetic reduced graphene oxide (Fe₃O₄@rGO-NH). The obtained Fe₃O₄@rGO-NH was used as a heterogeneous catalyst in the Gewald three-component reaction between some aldehydes or ketones, sulfur, and malononitrile or Et cyanoacetate. The catalyst showed good activity for various starting materials, easy separation from the reaction mixture using an ordinary magnet and reusability. Also, the catalyst was used six times without significant loss of activity. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Application of 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Application of 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts