Category: 99902-72-4

The author of 《Regioselective C-H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds》 were Gao, Chao; Li, Hongchen; Liu, Miaochang; Ding, Jinchang; Huang, Xiaobo; Wu, Huayue; Gao, Wenxia; Wu, Ge. And the article was published in RSC Advances in 2017. Recommanded Product: 6-Phenoxynicotinonitrile The author mentioned the following in the article:

A protocol for the auxillary directed C-H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone was developed. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C-H functionalization reaction of phenol derivatives to produce a variety of sym. and unsym. 2,4,6-trisubstituted phenols. In the experimental materials used by the author, we found 6-Phenoxynicotinonitrile(cas: 99902-72-4Recommanded Product: 6-Phenoxynicotinonitrile)

6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 6-Phenoxynicotinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Thieme Chemistry Journals Awardees – Where Are They Now? Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl) Ethers Using Heteroaryl Exchange Reaction》 was written by Tanii, Saori; Arisawa, Mieko; Tougo, Takaya; Horiuchi, Kiyofumi; Yamaguchi, Masahiko. SDS of cas: 99902-72-4 And the article was included in Synlett on August 31 ,2017. The article conveys some information:

Unsym. di(heteroaryl) ethers were synthesized by the rhodium-catalyzed heteroaryl exchange reaction of heteroaryl aryl ethers and heteroaryl esters at equilibrium [e.g., 2-phenoxybenzothiazole + 3-pyridyl benzoate → 2-(3-pyridyloxy)benzothiazole + Ph benzoate]. Diverse unsym. di(heteroaryl) ethers containing five- and six-membered heteroarenes were obtained. Di(heteroaryl) ethers can be synthesized starting from diaryl ethers, because heteroaryl aryl ethers are obtained by the heteroaryl exchange reaction of diaryl ethers. In the experiment, the researchers used many compounds, for example, 6-Phenoxynicotinonitrile(cas: 99902-72-4SDS of cas: 99902-72-4)

6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.SDS of cas: 99902-72-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Quan; Lu, Zhongxiang; Ren, Wenfei; Shen, Kaibo; Wang, Yu; Xu, Qing published an article in Chinese Journal of Chemistry. The title of the article was 《Efficient synthesis of unsymmetrical heteroaryl ethers by a transition metal-free C-O cross-coupling reaction of activated and unactivated heteroaryl chlorides with alcohols and phenols》.Application In Synthesis of 6-Phenoxynicotinonitrile The author mentioned the following in the article:

By optimizing the reaction conditions via a careful screening of the bases and solvents, an efficient transition metal-free method for C-O cross-coupling of activated and unactivated heteroaryl chlorides with primary and secondary alcs. and phenols was developed, providing a simple, efficient, and practical method for the synthesis of the useful unsym. heteroaryl alkyl and heteroaryl aryl ethers. The experimental part of the paper was very detailed, including the reaction process of 6-Phenoxynicotinonitrile(cas: 99902-72-4Application In Synthesis of 6-Phenoxynicotinonitrile)

6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Application In Synthesis of 6-Phenoxynicotinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Yongbao; Cameron, Beth R.; Skerlj, Renato T. published an article in Journal of Organometallic Chemistry. The title of the article was 《Cycloauration of substituted 2-phenoxypyridine derivatives and X-ray crystal structure of gold, dichloro[2-[[5-[(cyclopentylamino)carbonyl]-2-pyridinyl-κN]oxy]phenyl-κC]-, (SP-4-3)-》.Recommanded Product: 6-Phenoxynicotinonitrile The author mentioned the following in the article:

Direct cycloauration of 2-phenoxypyridines with different substituents at the 5-position of the pyridine ring was carried out in an CH3CN/H2O medium, leading to isolation of cycloaurated compounds AuCl2(L) (HL = substituted 2-phenoxypyridine ligand) with alkyl, substituted alkyl, Ph, halo, ester, and amido groups. Preparation of cycloaurated compounds involved formation of an intermediate AuCl3(HL) via coordination reaction between the pyridine ligand and NaAuCl4 at room temperature and subsequent formation of the Au-C bond at elevated temperature in an CH3CN/H2O medium. The presence of a bulky lipophilic group decreased the yield of cycloaurated compounds and favored decomposition of the reaction species to Au(0). No coordination reaction was observed for ligands with a strong electron-withdrawing substituent (nitro or nitrile) in the pyridine ring. The ligand having the electron-donating dimethylamino group was oxidized by NaAuCl4 at room temperature The presence of a thienyl or an acetyl group allowed the isolation of the intermediate AuCl3(HL), but had an adverse effect on the subsequent cycloauration. The result of direct cycloauration of methyl-substituted 2-phenoxypyridine ligands indicated that the presence of a Me group at the 6-position in the pyridine ring closest to the Au-N(py) bond resulted in poor cycloauration and a decrease in compound stability. The X-ray crystal structure of cycloaurated compound AuCl2L (L = [2-[[5-[(cyclopentylamino)carbonyl]-2-pyridinyl-κN]oxy]phenyl-κC]) 1 was determined, depicting a four-coordinate Au atom located in the center of a slightly distorted square. The results came from multiple reactions, including the reaction of 6-Phenoxynicotinonitrile(cas: 99902-72-4Recommanded Product: 6-Phenoxynicotinonitrile)

6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Recommanded Product: 6-Phenoxynicotinonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines》 were Markley, Lowell D.; Tong, Yulan C.; Dulworth, Jacqueline K.; Steward, David L.; Goralski, Christopher T.; Johnston, Howard; Wood, Steven G.; Vinogradoff, Anna P.; Bargar, Thomas M.. And the article was published in Journal of Medicinal Chemistry in 1986. Recommanded Product: 99902-72-4 The author mentioned the following in the article:

Seventy-four title compounds [I; R1 and R2 = e.g. H, 3-, 4-, 5-, or 6-MeSO2, 4-NO2, 2,4-(NO2)2, 4-MeSO2-2-CN, 5-CN, 4-MeO, 4-MeCONH-2-CN, etc.; R3 and R4 = e.g. H, 4-Cl, 3,4-Cl2, 4-COMe, 3,4-(MeO)2, 4-SMe 3-CF3, 4-CN, etc.; and X = CH or N] were prepared, mostly by nucleophilic aromatic substitution reactions of the appropriate phenol with aryl halides with subsequent functional group transformations where necessary, and tested for activity against picornaviruses (rhino- and coxsackie-virus) in vitro; selected I were also tested for protection from coxsackievirus infection in mice. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile  [78940-62-2] demonstrated broad-spectrum antipicornavirus activity; this compound and several of its analogs were also effective antiviral agents in vivo. Some structure-activity relations are discussed.6-Phenoxynicotinonitrile(cas: 99902-72-4Recommanded Product: 99902-72-4) was used in this study.

6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Recommanded Product: 99902-72-4 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts