Category: 99835-27-5

Du, Bingnan et al. published their research in Journal of Organic Chemistry in 2013 | CAS: 99835-27-5

4-Bromo-2,6-dichlorobenzonitrile (cas: 99835-27-5) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Category: nitriles-buliding-blocks

Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group was written by Du, Bingnan;Jiang, Xiaoqing;Sun, Peipei. And the article was included in Journal of Organic Chemistry in 2013.Category: nitriles-buliding-blocks This article mentions the following:

A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature Using cyano as the directing group, the halogenation reaction gave good to excellent yields. E.g., in presence of Pd(OAc)2 and p-toluenesulfonic acid, reaction of PhCN and NIS gave 84% 2-IC6H4CN. The method is compatible for arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available at least the gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F. In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-dichlorobenzonitrile (cas: 99835-27-5Category: nitriles-buliding-blocks).

4-Bromo-2,6-dichlorobenzonitrile (cas: 99835-27-5) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some tips on 4-Bromo-2,6-dichlorobenzonitrile

According to the analysis of related databases, 99835-27-5, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 99835-27-5 as follows. Computed Properties of C7H2BrCl2N

Synthesis of compound 9.3. To a solution of compound 9.2 (1.6 g, 6.37mmol, 1.0 equiv) in toluene (28 mL) was added ammonium chloride (1.7g, 31.8mmol, 5.0 equiv) at room temperature. Trimethylaluminum solution (2M in toluene) (2.29g, 31.8 mmol, 5.0 equiv) was added slowly under a nitrogen atmosphere. The mixture was heated at 110 C for 48 hrs. Upon completion, the reaction mixture was cooled to room temperature and silica was added followed by chloroform (50 mL). The resulting suspension was stirred for 30 minutes, filtered and the filter cake washed with 20% methanol in dichloromethane. The filtrate was concentrated under reduced pressure to obtain crude material, which was triturated with 10% ethyl acetate in hexane to yield compound 9.3 (1.6 g, 93%). MS (ES): m/z 269 [M+H]+.

According to the analysis of related databases, 99835-27-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts