Adding a certain compound to certain chemical reactions, such as: 97582-88-2, name is 3-(Difluoromethoxy)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97582-88-2, Safety of 3-(Difluoromethoxy)benzonitrile
(1) A Grignard reagent prepared by using 0.75 g of magnesium, 4.46 g of 2-bromopropane and 24 ml of anhydrous diethyl ether, was dropwise added to a mixture comprising 4.09 g of 3-difluoromethoxybenzonitrile and 20 ml of anhydrous diethyl ether. After completion of the dropwise addition, the mixture was reacted at room temperature for 27 hours. The reaction mixture was put into ice water, and 6N sulfuric acid was added to bring the mixture to be weakly acidic, followed by stirring for 0.5 hour. The mixture was extracted with diethyl ether and washed with water. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (developing solvent: ethyl acetate/n-hexane=l/19), to obtain 2.04 g of 3-difluoromethoxyisobutyrophenone. The NMR spectrum data of this product is as follows.XH-NMR 5ppm (Solvent: CDCl3/300 MHz)1.23(d,6H),3.52(m,lH),6.56(t,lH),7.32(dd,lH),7.48(t, 1H),7.70(s,lH),7.80(d,lH)
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Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.; WO2006/16708; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts