Category: 97165-77-0

Related Products of 97165-77-0, The chemical industry reduces the impact on the environment during synthesis 97165-77-0, name is 3,5-Dibromobenzonitrile, I believe this compound will play a more active role in future production and life.

In a single-necked flask, intermediate 4-1 (3 g, 12 mmol), 3,5-dibromobenzonitrile (3.1 g, 12 mmol), cuprous bromide (0.18 mmol, 27 mg), o-phenanthroline (0.18 (33 mg), zinc iodide (0.37 mmol, 118 mg) and o-dichlorobenzene (30 mL) at 150 C for 24 hours. After cooling to room temperature, the mixture was diluted with methylene chloride and the inorganic salt was removed by filtration. Column chromatography afforded 3 g of a white solid in 50% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (29 pag.)CN107033143; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 97165-77-0, name is 3,5-Dibromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97165-77-0, Quality Control of 3,5-Dibromobenzonitrile

3,5-dibromobenzene cyanide (20.0 mmol) under nitrogen protection,1-THP-4-pyrazoleboronic acid pinacol ester (48.0 mmol) and 1,4-dioxane (120 mL) and water (30 mL) were added to a 250 mL round bottom flask.Add magnetron stirring, then add K2CO3 (60.0mmol)And Pd(PPh3)4 (1.0 mmol), the reaction was stirred at 100 C for 24 hours. After the reaction is completed, the solvent of the reaction system is spin-dried.The residue was dissolved in ethyl acetate (200 mL).Wash with water (150 mL × 2) and saturated brine (200 mL),After drying over anhydrous Na 2 SO 4 , filtered and concentrated.The crude product was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 20:1 to 1:1).After concentration, 3,5-bis(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenyl cyanide was obtained as a pale yellow solid (yield: 84%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Beijing University of Technology; Li Jianrong; Kong Xiangjing; Zhang Yongzheng; He Tao; (10 pag.)CN109851559; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 97165-77-0, name is 3,5-Dibromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97165-77-0, name: 3,5-Dibromobenzonitrile

15.0 g (52.2 mmol) of (9-phenyl-9H-carbazol-3-yl)boronic acid, 27.3 g (104 mmol) of 3,5-dibromobenzonitrile, 3.02 g (2.61 mmol) of tetrakistriphenylphosphine palladium(0) (Pd(PPh3)4), and 18.1 g (131 mmol) of potassium carbonate were added to a solution of 120 ml of THF and 60 ml of water and mixed. The mixed solution was then stirred under reflux. After completion of the reaction, the resulting reaction solution was cooled to room temperature, and an extraction process was performed thereon to remove an aqueous solution layer therefrom. The obtained residue was filtered through silica gel under reduced pressure, and the filtrate was concentrated under reduced pressure. The resulting residue was then separated by silica gel column chromatography, thereby providing 11.9 g (yield: 54%) of a desired compound, Intermediate (R). LC-Mass (cald: 422.04 g/mol, found: M+1=423 g/mol).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAMSUNG ELECTRONICS CO., LTD.; Samsung SDI Co., Ltd.; JUNG, Yongsik; HUH, Dalho; SON, Jhunmo; KWON, Eunsuk; KIM, Sangmo; LEE, Saeyoun; JEON, Soonok; CHUNG, Yeonsook; KIM, Jongsoo; IHN, Sooghang; (219 pag.)US2017/369439; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 97165-77-0, name is 3,5-Dibromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97165-77-0, Computed Properties of C7H3Br2N

3-Bromo-5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]benzonitrile Tetrabutylammonium fluoride (21 mL, 1M in THF, 21 mmol) was added to a mixture of 3,5-dibromobenzonitrile (5.0 g, 19 mmol), 2-methyl-4-[(trimethylsilyl)ethynyl]-1,3-thiazole (3.8 g, 19 mmol), triethylamine (5.5 mL, 40 mmol), copper (I) iodide (730 mg, 3.8 mmol), dichlorobis(triphenylphosphine)palladium(II) (1.4 g, 1.9 mmol), and N,N-dimethylformamide (25 mL). Nitrogen was bubbled through the resulting mixture for 30 min, and the reaction was heated at 90 C. for 5 h. The reaction was allowed to cool to ambient temperature, poured into a solution of H2O (500 mL) and NH4OH (150 mL), and extracted with methyl tert-butyl ether (100 mL*3). The combined organic extracts were dried (MgSO4), filtered, and concentrated in vacuo. The residue was chromatographed on silica gel with hexanes:EtOAc (9:1?1:1) to afford 3-bromo-5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]benzonitrile as a light-brown solid. 1H NMR (CDCl3, 500 MHz) delta 7.90 (t, J=1.6 Hz, 1H), 7.76-7.73 (m, 2H), 7.46 (s, 1H), 2.75 (s, 3H). MS (ESI) 303.2 (M++H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; US2007/60618; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 97165-77-0, The chemical industry reduces the impact on the environment during synthesis 97165-77-0, name is 3,5-Dibromobenzonitrile, I believe this compound will play a more active role in future production and life.

In a single-necked flask, intermediate 4-1 (3 g, 12 mmol), 3,5-dibromobenzonitrile (3.1 g, 12 mmol), cuprous bromide (0.18 mmol, 27 mg), o-phenanthroline (0.18 (33 mg), zinc iodide (0.37 mmol, 118 mg) and o-dichlorobenzene (30 mL) at 150 C for 24 hours. After cooling to room temperature, the mixture was diluted with methylene chloride and the inorganic salt was removed by filtration. Column chromatography afforded 3 g of a white solid in 50% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (29 pag.)CN107033143; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 97165-77-0, A common heterocyclic compound, 97165-77-0, name is 3,5-Dibromobenzonitrile, molecular formula is C7H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,3,6,8-tetramethyl-9H-carbazole (1.07 g, 4.80 mmol), 3,5-dibromobenzonitrile (0.522 g, 2.00 mmol), sodium tert-butoxide (0.768 g, 8.00 mmol), tris (dibenzylideneacetone) dipalladium (O) (92.8 mg, 0.101 mmol) and tetrafluoroborate tri-tert-butylphosphine (0.220 g, 0.758 mmol) were added to a 100 mL three-neck flask having been substituted with nitrogen. The mixture was added with 35 mL of dehydrated toluene and stirred under heating at 95 C. for 12 hours. After the mixture was returned to room temperature, the mixture was added with chloroform and stirred. Then, the solution was rinsed with saturated saline. After the rinsing, the solution was added with anhydrous magnesium sulfate and dried. After the drying, the mixture was subjected to suction filtration for concentration, so that filtrate was obtained. The obtained filtrate was purified by silica gel column chromatography with hexane:chloroform (=2:1) as a developing solvent. The white solid matter obtained by concentrating the obtained fraction was stirred under heating by hexane and then filtered. The solid matter recovered by filtration was recrystallized with toluene, so that the white crystals of the target material were obtained in a yield amount of 470 mg and a yield of 45.0%. 1H-NMR (500 MHz, CDCl3, delta): 8.07 (d, J=2.0 Hz, 2H), 7.63 (s, 4H), 7.07 (t, J=2.0 Hz, 1H), 6.88 (s, 4H), 2.42 (s, 12H), 1.98 (s, 12H). ASAP mass spectrum analysis: Theoretical value: 545.7 Observed value: 545.7

The synthetic route of 97165-77-0 has been constantly updated, and we look forward to future research findings.

Application of 97165-77-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 97165-77-0 as follows.

To a flask was added 3,5-dibromobenzonitrile (3 g, 11.6 mmol), 4-(1-naphthyl)-benzenesulfonic acid (2.9 g, 11.6 mmol), potassium carbonate (4.1 g, 30 mmol)tetraphenyllphosphine palladium (0.1 g),tetrahydrofuran (30 mL) and water (15 mL)heated to reflux under nitrogen for 12 hours, cooled, extracted with dichloromethane, dried and concentrated. The crude product was purified by column chromatography to give 2.5 g of product in 57% yield.

According to the analysis of related databases, 97165-77-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (29 pag.)CN107033143; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 97165-77-0, name is 3,5-Dibromobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H3Br2N

Compound II – 2 (2.61 g, 10 mmol), compound III (2.06 g, 10 mmol), Pd (OAc)2(0.22 G, 1 mmol), BINAP (2, 2 ‘- bi-phenyl diphenylphosphino – 1, 1’ – binaphthyl, 0.62 g, 1 mmol) and t – BuOK (2.24 g, 20 mmol) is added to the 50 ml dry 1, 2 – dimethoxy ethane (DME), the reaction mixture is stirred under a nitrogen atmosphere overnight, detected in the TLC reaction is completed.The reaction mixture carefully dumped into 200 ml ice water, stirring, for 50 ml ¡Á 3 CH2Cl2Extraction, the combined extraction phase, for sequentially 1% dilute hydrochloric acid and salt is washed with water, dried with anhydrous sodium sulfate. Oil filtration to remove the drying agent, the filtrate on a rotary evaporator to dryness, the residue using silica gel column chromatography purification, to obtain compound IV – 2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 97165-77-0.

Reference:
Patent; Guangdong Sai Bo Technology Co., Ltd.; Guo Huijun; (8 pag.)CN107903271; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 97165-77-0,Some common heterocyclic compound, 97165-77-0, name is 3,5-Dibromobenzonitrile, molecular formula is C7H3Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 79 3-(2′-amino-1^2,2-trimethyl-5′-oxo-r,5′-dihydrospiro[chroman-4,4′-imidazole]-6-yl)-5- bromobenzonitrileA resealable glass pressure tube was charged with 2′-amino-l’,2,2-trimethyl-6-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)spiro[chroman-4,4′-imidazol]-5′(rH)-one (50 mg, 0.13 mmol), 3,5-dibromobenzonitrile (34 mg, 0.13 mmol), dichloro[l, -bis(diphenylphosphino)ferrocene]palladium (II) dichloromethane adduct (5.3 mg, 0.0065 mmol), 20% aqueous Na2C03 (241 mu., 0.45 mmol), and 1 ,4-dioxane (1.3 mL, 0.13 mmol). The reaction mixture was sparged with N? for 5 minutes, capped, stirred at 90C for 2 hours and allowed to cool to room temperature. The mixture was then diluted with EtOAc ( 10 mL) and washed with water (2 mL). The organic layer was separated, dried (MgS04), filtered and concentrated in vacuo. The residue obtained was purified by flash chromatography on silica gel (Biotage Flash 40S+) eluting with 5% MeOH/DCM. The product isolated was triturated with EtOAc. The solid formed was filtered, washed with additional EtOAc (2 X 1 mL) to provide 3-(2′-amino-r,2,2-trimethyI-5′-oxo- ,5′- dihydrospiro[chroman-4,4′-imidazole]-6-yl)-5-bromobenzonitrile ( 12 mg, 21% yield) as a solid. ‘H NMR (400 MHz, (CD3)2SO) delta 8.05 (s, 1H), 7.97 (s, 2H), 7.54 (d, J=7.04Hsz, 1H), 6.99 (s, 1 H), 6.88 (d,J=8.61Hz, 1H), 6.52 (br s, 2H), 3.05 (s, 3H), 2.19 (d, J=14.08 Hz, 1H), 1.82 (d, J=14.08 Hz, 1H), 1.43 (s, 3H), 1.39 (s, 3); LCMS (APCI+) m/z 439, 442 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromobenzonitrile, its application will become more common.

Reference:
Patent; ARRAY BIOPHARMA INC.; HUNT, Kevin, W.; RIZZI, James, P.; COOK, Adam; WO2011/72064; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 97165-77-0,Some common heterocyclic compound, 97165-77-0, name is 3,5-Dibromobenzonitrile, molecular formula is C7H3Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A round-bottomed flask was charged with 3,5-dibromobenzonitrile (15.65 g, 60.00 mmol), sodium azide (7.80 g, 120.00 mmol) and zinc bromide (27.00 g, 120.00 mmol). After degassed, DMF (100 mL) was added. The reaction mixture was heated to 120 C and stirred at this temperature until complete. The reaction was cooled to rt and then in an ice-water bath. 300 mL of IN aqueous HCl was added. The white precipitate formed was collected by suction filtration, washed with water, and dried together with phosphorous pentoxide under vacuum to afford 17.32 g (95 %) of product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromobenzonitrile, its application will become more common.

Reference:
Patent; DENOVAMED INC.; WU, Fan; LU, Erhu; BARDEN, Christopher J.; WO2012/116452; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts