In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 960370-97-2 as follows. name: 1-Cyclopropyl-4-oxocyclohexanecarbonitrile
e). To the ketone prepared in step d (6.0 g, 37 mmol) in dichloroethane (110 mL) was added cyclopropylamine (3.1 mL, 44 mmol). The solution was cooled to 0 C. (ice bath), and NaBH(OAc)3 (12 g, 55 mmol) and AcOH (2.8 mL, 48 mmol) were added. After 5 minutes the ice bath was removed. The reaction was stirred at room temperature for 4 h. The contents were diluted with CH2Cl2 (100 mL) poured in water (100 mL). The aqueous layer was brought to pH 2 with 5 N HCl. Following removal of the organic layer, the aqueous layer was brought to pH 12 with 5 N NaOH and extracted with 10% MeOH in CH2Cl2 (3¡Á35 mL). The combined organics were dried with Na2SO4 and concentrated in vacuo. Silica gel chromatography (gradient of 5 to 10% ethyl acetate in hexanes with 2.5% triethylamine additive) gave the cis amine followed by the trans amine. 1H NMR (500 Hz, CDCl3, trans isomer): delta 0.15-0.17 (m, 2H), 0.25-0.29 (m, 2H), 0.34-0.37 (m, 4H), 0.58-0.63 (m, 1H), 1.22-1.31 (m, 4H), 1.84-1.90 (m, 4H), 1.96-2.00 (m, 1H), 2.38-2.40 (m, 1H).
According to the analysis of related databases, 960370-97-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Amgen Inc.; US2007/299080; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts