Category: 94087-40-8

Osipyan, Angelina; Sapegin, Alexander; Novikov, Alexander S.; Krasavin, Mikhail published the artcile< Rare Medium-Sized Rings Prepared via Hydrolytic Imidazoline Ring Expansion (HIRE)>, Synthetic Route of 94087-40-8, the main research area is thiazepine dihydroimidazo alkyl halide hydrolytic imidazoline ring expansion; thiazecine preparation.

The hydrolytic imidazoline ring expansion (HIRE) methodol. was extended to readily available tetracyclic [1,4]thiazepines as well as sulfoxide and sulfone analogs thereof. The reactions resulted in the facile formation of a rare medium-sized [1,4,7]thiazecine ring system that has an emerging utility in bioactive compound design. Comparing the HIRE rates for representative compounds in the three groups of substrates allowed drawing some generalizations about the substituent effects on the course of the reaction.

Journal of Organic Chemistry published new progress about Alkylation. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Synthetic Route of 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Taldone, Tony; Patel, Pallav D.; Patel, Hardik J.; Chiosis, Gabriela published the artcile< About the reaction of aryl fluorides with sodium sulfide: investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via SNAr displacement of fluorine>, COA of Formula: C7H3ClFN, the main research area is mercaptobenzonitrile synthesis aryl fluoride sulfide substitution.

In this report we describe a simple synthesis of mercaptobenzonitriles from the reaction of fluorobenzonitriles with Na2S in DMF at room temperature and following direct treatment with Zn/HCl. Significantly, 2- and 4-fluorobenzonitriles substituted with chlorine or bromine, but not iodine, undergo selective substitution of fluorine at room temperature to yield synthetically useful halo-substituted mercaptobenzonitriles.

Tetrahedron Letters published new progress about Aromatic substitution reaction. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, COA of Formula: C7H3ClFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Haoran; DiMagno, Stephen G. published the artcile< Room-temperature nucleophilic aromatic fluorination: experimental and theoretical studies>, Name: 3-Chloro-2-fluorobenzonitrile, the main research area is fluorination aromatic tetrabutylammonium fluoride; fluorobenzene preparation.

The use of anhydrous tetrabutylammonium fluoride in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes, was investigated. It was shown that TBAF permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.

Angewandte Chemie, International Edition published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Name: 3-Chloro-2-fluorobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feng, Jian-Bo; Wu, Xiao-Feng published the artcile< Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions>, Recommanded Product: 3-Chloro-2-fluorobenzonitrile, the main research area is pyridoquinazolinimine preparation; aminopyridine fluorobenzonitrile cyclization nucleophilic aromatic substitution; quinazolinamine preparation; amidine fluorobenzonitrile cyclization nucleophilic aromatic substitution.

A convenient procedure for the synthesis of pyrido[1,2-a]quinazolinimines e.g., I and quinazolinamines e.g., II was developed via cyclization of 2-fluorobenzonitriles with 2-aminopyridines or amidines resp. through SNAr reactions using potassium tert-butoxide as the promoter. Using this methodol., the desired pyrido[1,2-a]quinazolinimines and quinazolinamines were obtained in moderate to good yields under catalyst-free conditions.

Organic & Biomolecular Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Recommanded Product: 3-Chloro-2-fluorobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mo, Xueling; Chen, Bin; Zhang, Guozhu published the artcile< Copper-Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α-Bromoamides>, Category: nitriles-buliding-blocks, the main research area is copper catalyst enantioselective Sonogashira coupling alkyne alpha bromoamide; Sonogashira reaction; copper catalysis; enantioselectivety; terminal alkynes; α-bromoamide.

An asym. copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides was developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylaniline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reutskaya, Elena; Osipyan, Angelina; Sapegin, Alexander; Novikov, Alexander S.; Krasavin, Mikhail published the artcile< Rethinking Hydrolytic Imidazoline Ring Expansion: A Common Approach to the Preparation of Medium-Sized Rings via Side-Chain Insertion into [1.4]Oxa- and [1.4]Thiazepinone Scaffolds>, Application of C7H3ClFN, the main research area is hydrolytic imidazoline ring expansion medium size ring synthesis.

The previously reported ring-expansion strategy involving hydrolytically prone imidazoline rings was thought to include the formation of a hydrated imidazoline intermediate. In this work, we accessed the latter via the addition of a 2-aminoethyl side chain onto a lactam moiety. This led to an efficient three-atom ring expansion of diarene-fused [1.4]oxazepines and [1.4]thiazepines and led us to propose to term this common approach the hydrated imidazoline ring expansion (HIRE) reaction. The strategy was extended to the insertion of longer (containing up to five atoms) side chains, and thus, larger (11- to 12-membered) diarene-fused rings were obtained via the homo-HIRE and homo2-HIRE reactions, resp. This underscores the utility of the HIRE reaction for the preparation of medium-sized rings, an important class of chem. tools for interrogation of various biol. targets.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (reductive alkylation agents). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Application of C7H3ClFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dmitriev, Viktor; Vedekhina, Tatiana; Sapegin, Alexander; Krasavin, Mikhail published the artcile< Convenient Assembly of Privileged (Hetero)Arene-Fused Benzo[1.4]oxazepines via Two Tandem SNAr Events. Part 3 - (Hetero)arene-Fused benzo[f]imidazo[1,2-d][1,4]oxazepines>, Application of C7H3ClFN, the main research area is heteroarene fused benzo imidazo oxazepine preparation regioselective; aryl imidazole ortho dihalo halonitro arene Smiles rearrangement.

A tandem approach to (hetero)arene-fused benzo[f]imidazo[1,2-d][1,4]oxazepines I (R1 = H, Cl; R2 = H, R1 = R2 = -C4H4-; R3 = H, Me, R2 = R3 = -C4H4-; R4 = CN, NO2, COOMe, etc.; X = C, N, C-CN; Y = C, N) has been described which involves condensation of bis-nucleophilic 2-(2-hydroaryl)imidazoles II with reactivity-matched o-dihalo and o-halonitro (hetero)aromatic substrates III (LG1 = F, Cl; LG2 = F, Cl, Br, NO2). The process is generally regioselective with respect to the unsym. substituted imidazole ring and proceeds via two SNAr events (intermol. first and then intramol.) intermitted by a Smiles rearrangement. In some cases, the last SNAr step provides a rare example of nucleophilic displacement of a nitro group or a halogen in non-activated positions of a (hetero)aromatic ring which does not require the use of a metal catalyst.

ChemistrySelect published new progress about Aromatic nitro compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Application of C7H3ClFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Whyte, Andrew; Burton, Katherine I.; Zhang, Jingli; Lautens, Mark published the artcile< Enantioselective Intramolecular Copper-Catalyzed Borylacylation>, Quality Control of 94087-40-8, the main research area is enantioselective intramol copper catalyst borylacylation; mol structure crystal boronic ester preparation chiral; asymmetric catalysis; boron; copper; cyclizations; heterocycles.

An enantioselective copper-catalyzed intramol. borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon-boron bond provides a platform for a wide array of diversification.

Angewandte Chemie, International Edition published new progress about Acylation, stereoselective. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Quality Control of 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feng, Jian-Bo; Wu, Xiao-Feng published the artcile< Base-promoted synthesis of dibenzoxazepinamines and quinazolinimines under metal-free conditions>, Synthetic Route of 94087-40-8, the main research area is dibenzooxazepinamine quinazolinimine preparation.

An interesting base-promoted protocol for the synthesis of dibenzo[b,f][1,4]oxazepin-11-amines, e.g., I and quinazolinimines II (R = H, 2-F, 4-OMe, 3-Br, 3-Cl; R1 = H, 9-F, 7-OMe, 8-Br, 8-Cl; X = O, S) has been developed. Starting from com. available 2-fluorobenzonitriles R2CN (R2 = 2-FC6H4, 6-H2N-2-FC6H3, 5-H3C-2-FC6H3, etc.) and amines R3NH2 (R3 = 2-HOC6H4, CH2CH2OH, 3-hydroxynaphthalen-2-yl, etc.), good to excellent yields can be achieved. Notably, only K3PO4 or K2CO3 was required as the promoter here and the reaction can be easily performed on a large scale.

Green Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Synthetic Route of 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Prasad, A. S. G.; Rao, T. Bhaskara; Rambabu, D.; Basaveswara Rao, Mandava V.; Pal, Manojit published the artcile< Ultrasound Assisted Faster and Milder Approach to 6H-pyrido[1,2-a] quinazolin-6-imine Derivatives as Potential Inhibitors of PDE4>, Safety of 3-Chloro-2-fluorobenzonitrile, the main research area is aminopyridine Quinazolinimine pinner reaction bioactive agents potential inhibitor.

Background: The ultrasound assisted methodol. has been explored first time for the quicker synthesis of 6H-pyrido[1,2-a]quinazolin-6-imine derivatives via the reaction of 2-aminopyridines and 2-fluorobenzontriles under mild conditions. Methods: The methodol. is free from the use of any transition metal catalyst and afforded the desired products in good yields. Some of the synthesized compounds were evaluated for their potential PDE4 inhibition in silico and subsequently in vitro. Conclusion: One compound showed dose dependent inhibition of PDE4B and favorable pharmacol. properties indicating potential of this scaffold for the discovery of new inhibitors of PDE4.

Letters in Drug Design & Discovery published new progress about 94087-40-8. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Safety of 3-Chloro-2-fluorobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts