Category: 939-79-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: nitriles-buliding-blocks

To a mixture of 4-bromobenzaldehyde (2; 100g, 543 mmol) and piperidine (26 mL, 260 mmol) was added 4-cyano-2-nitrotoluene (1; 92 g, 567mmol). The resulting slurry was heated at 125 C for 4 h until it became a solid. After cooling to room temperature, CH2Cl2 (200 mL) was added to the solid mass and the mixture was stirred for 30 min. To the resulting mixture was added hexane (200mL), and the suspension was stirred at room temperature overnight. The solid was filtered, washed with hexane (1 L), and dried under vacuum to provide 178 g (99 %) of product as yellow solid, which was used in the next step without further purification.

The synthetic route of 939-79-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nguyen, Son T.; Williams, John D.; Butler, Michelle M.; Ding, Xiaoyuan; Mills, Debra M.; Tashjian, Tommy F.; Panchal, Rekha G.; Weir, Susan K.; Moon, Chaeho; Kim, Hwa-Ok; Marsden, Jeremiah A.; Peet, Norton P.; Bowlin, Terry L.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3366 – 3372;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 939-79-7, The chemical industry reduces the impact on the environment during synthesis 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.

Furan-2,5-dicarboxaldehyde (197mg, 1.6mmol) and 4-cyano-2-nitrotoluene (12; 600mg, 3.7mmol) were dissolved in sulfolane (1mL) to which was added piperidine (200 muL, 2.0mmol). The mixture was heated to 150C in a sealed tube for 30min, producing a dark suspension. The reaction was cooled to room temperature, and MeOH (5mL) and Et2O (5mL) were added. The solids were triturated, filtered, rinsed with Et2O, and dried to yield 417mg (64%) of product as a brown powder. Material is too insoluble for 1H NMR evaluation.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Williams, John D.; Nguyen, Son T.; Gu, Shen; Ding, Xiaoyuan; Butler, Michelle M.; Tashjian, Tommy F.; Opperman, Timothy J.; Panchal, Rekha G.; Bavari, Sina; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7790 – 7806;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 939-79-7, These common heterocyclic compound, 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 4-methyl-3-nitrobenzontitrile (2.4Ig), 10% Pd on C ( ~lg) and ethanol was stirred under hydrogen. After 24 hours the reaction mixture was filtered through Celite, and the solvent reduced in vacuo and purified using flash chromatography to yield 3-amino-4-methyl-benzonitrile (1.2Ig).

Statistics shows that 4-Methyl-3-nitrobenzonitrile is playing an increasingly important role. we look forward to future research findings about 939-79-7.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/93049; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-79-7, category: nitriles-buliding-blocks

Dissolve sodium metal (0.345 g) in absolute EtOH (25 mL), add diethyloxalate (10 mL) and then add 4-methyl-3-nitrobenzonitrile (lb, m=0, 1.6 g, Aldrich) as an EtOH solution (25 mL). Stir the reaction mixture at rt for 16 hours, neutralize the reaction by addition of 5N HC1 (3 mL) and remove the EtOH under reduced pressure. Partition the residue between CH2C12 (100 mL) and H20 (50 mL). Wash the organic layer successively with H20 (50 mL) and brine (50 mL), dry (MgSO4) and concentrate to give a crude oil. Purify the oil by chromatography on SiO2 eluting with cyclohexane-EtOAc, 70-30 v/v, to afford gave after drying (40C, house vacuum), the title compound (1.5 g) as yellow crystals, mp 118 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/23467; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 939-79-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

4-methyl-3- nitrobenzonitrile (Compound 11, manufactured by Tokyo Chemical Industry Co., Ltd.) (965.0 mg, 5.95 mmol) Was dissolved in carbon tetrachloride (10 mL), N-bromosuccinimide (1.270 g, 7.14 mmol) and azobisisobutyronitrile (390.8 mg, 2.38 mmol) were added, and under argon gas atmosphere, 2 And heated under reflux for days. After completion of the reaction, the reaction solution was cooled, water was added, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = 8/1) to obtain Compound 12 (724 mg, 2.99 mmol, yield 50%).

The chemical industry reduces the impact on the environment during synthesis 4-Methyl-3-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NIHON MEDI-PHYSICS COMPANY LIMITED; KYOTO UNIVERSITY; IZAWA, AKIHIRO; OKUMURA, YUKI; KOBASHI, NOBUYA; ABE, TSUTOMU; SAJI, HIDEO; KIMURA, HIROYUKI; (34 pag.)JP2015/93832; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-79-7, Computed Properties of C8H6N2O2

A mixture of 3-nitro-p-tolunitrile (9.30 g, 57.4 mmol, 1 equiv) and 10% Pd/C (4.00 g, 3.76 mmol, 0.066 equiv) in ethanol (100 mL) was stirred under a hydrogen balloon at 23 0C for 20 h. The catalyst was filtered onto a pad a celite and washed with EtOAc (300 mL). The filtrate was concentrated to give 3- amino-4-methylbenzonitrile (1-2) as an off-white solid. 1H NMR (300 MHz, CDCl3) delta 7.10 (d, IH, J= 7.6 Hz), 6.98 (dd, IH, J = 7.9, 1.5 Hz), 6.89 (d, IH, J= 1.5 Hz), 3.78 (br s, 2H), 2.20 (s, 3H). LRMS m/z (M+H + CH3CN) 174.2 found, 174.1 required

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2007/88400; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-79-7, Formula: C8H6N2O2

A mixture of 3-nitro-p-tolunitrile (9.30 g, 57.4 mmol, 1 equiv) and 10% Pd/C (4.00 g,3.76 mmol, 0.066 equiv) in ethanol (100 mL) was stirred under a hydrogen balloon at 23 C for 20 h. The catalyst was filtered onto a pad a celite and washed with EtOAc (300 mL). The filtrate was concentrated to give 3-amino-4-methylbenzonitrile (1-2) as an off-white solid. 1H NMR (300 MHz, CDCl3) delta 7.10 (d, 1H, J = 7.6 Hz), 6.98 (dd, 1H, J = 7.9, 1.5 Hz), 6.89 (d, 1H, J = 1.5 Hz), 3.78 (br s, 2H), 2.20 (s, 3H). LRMS m/z (M+H + CH3CN) 174.2 found, 174.1 required.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MERCK & CO., INC.; WO2006/86255; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 939-79-7

B. 4-Cyano-2-nitrobenzoic acid. To a 0 C. solution of 4-methyl-3-nitrobenzonitrile (5.0 g, 0.031 mol) in H2SO4 (83 mL) was added dropwise over 2 h a mixture of Na2Cr2O7 (14 g, 0.047 mol) and H2SO4 (15 mL). The reaction mixture was allowed to warm to room temperature with stirring over 48 h. The resulting green mixture was poured onto crushed ice, and the precipitate was collected by filtration. The filtered solids were dissolved in 5% aq. Na2CO3 (60 mL) and the residual solids were removed by filtration. The filtrate was treated with dilute HCl and the resulting precipitate was collected by filtration and dried in air to provide the title compound as a white solid (2.7 g, 46%). 1H NMR (500 MHz, CD3OD): 8.39 (d, J=1.3 Hz, 1H), 8.12 (dd, J=8.0, 1.3 Hz, 1H), 8.00 (d, J=8.0, 1H).

The synthetic route of 939-79-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Allison, Brett D.; Hack, Michael D.; Phuong, Victor K.; Rabinowitz, Michael H.; Rosen, Mark D.; US2005/38032; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 939-79-7 as follows. HPLC of Formula: C8H6N2O2

(2) 4-Bromomethyl-3-nitrobenzonitrile A solution of 4-methyl-3-nitrobenzonitrile (30 g), N-bromosuccinimide (37 g) and azobisisobutyronitrile (3.1 g) in carbon tetrachloride (300 ml) was refluxed under heating for 8 hr. To the reaction mixture was added water (100 ml) and the mixture was extracted with chloroform. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by silica gel column chromatography (developing solvent; ethyl acetate_hexane=1:4) and recrystallized from ethyl acetate-hexane to give the title compound (23.7 g) as pale-yellow crystals, m.p.=85-89 C. 1H-NMR(DMSO-d6)delta: 4.96(2H, s), 7.97(1H, d, J=7.9 Hz), 8.22(1H, dd, J=1.3, 7.9 Hz), 8.61(1H, d, J=1.3 Hz); IR(KBr): 3082, 2235, 1614, 1530 cm-1; MS(EI): 241(M+); Elemental analysis: Calculated: C; 39.86, H; 2.09, N; 11.62; Found: C; 40.64, H; 2.15, N; 11.85.

According to the analysis of related databases, 939-79-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Pharma Corporation; US6455528; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

939-79-7, These common heterocyclic compound, 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of 3-(4-Methyl-3-nitro-phenyl)-4H-[1,2,4]triazole Hydrogen chloride was bubbled through a solution of 3-nitro-p-tolunitrile (0.49 g, 3 mmol) in 40 mL of ethanol at room temp for 10 min. The solution was continued stirring at room temp for 60 min and the solvent was then evaporated under vacuum to dryness to give a white solid. The intermediate so obtained was dissolved in 20 mL of ethanol, neutralized with sodium ethoxide solution and the resulting precipitate was removed by filtration. To the filtrate was added at room temp formic hydrazide (0.2 g, 3 mmol) and the solution was continued stirring at room temp for 2 h. After removal of volatiles in vacuo, the residue was dissolved in 30 mL of m-xylene and refluxed at 150 C. for 16 h. Removal of volatiles in vacuo and purification using flash chromatography afforded 0.26 g of the final productproduct. (Yield: 43%). MS (m/z) calcd for C9H8N4O2 (MH+) 205.2, found, 205.1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 939-79-7.

Reference:
Patent; Bristol-Myers Squibb Company; Pharmaceopeia, Inc.; US6906067; (2005); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts