Poppe, Leszek published the artcileStructural and Thermodynamic Model for the Activation of Cardiac Troponin, Category: nitriles-buliding-blocks, the main research area is cardiac troponin activator structure thermodn model.
Cardiac troponin is a regulatory protein complex located on the sarcomere that regulates the engagement of myosin on actin filaments. Low-mol. weight modulators of troponin that bind allosterically with the calcium ion have the potential to improve cardiac contractility in patients with reduced cardiac function. Here we propose an approach to the rational design of troponin modulators through the combined use of solution NMR and isothermal titration calorimetry methods. In contrast to traditional approaches limited to calcium and activator-bound troponin structures, here we analyzed the structural and thermodn. impact of an activator in the context of the troponin functional cycle. This led us to propose a rationale for developing an efficacious troponin activator.
Biochemistry published new progress about Conformational transition. 936850-33-8 belongs to class nitriles-buliding-blocks, name is 3-Methylazetidine-3-carbonitrile hydrochloride, and the molecular formula is C5H9ClN2, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts