Category: 935-02-4

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 935-02-4 as follows. Computed Properties of C9H5N

The mixture of phenol (0.1 g, 1.1 mmol), 3-phenylpropiolonitrile (0.13 g, 1.0 mmol), sodium carbonate (0.11 g, 1.0 mmol) in DMF (2 mL) was stirred at room temperature for 12 h. The reaction was monitored by TLC. After the completion of the reaction, the mixture was extracted with ethyl acetate (3×10 mL), and the liquor was washed with saturated brine (3×10 mL). The resulting organic phase was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to give product (0.22 g, 99% ). (Z)-3-Phenoxy-3-phenylacrylonitrile (3a)5 Colorless oil. 1H NMR (400 MHz, CDCl3) delta 7.47 (d, J = 7.0 Hz, 2H), 7.34 (d, J = 7.2 Hz, 1H), 7.29 (d, J = 7.8 Hz, 2H), 7.23 – 7.18 (m, 2H), 7.01 (t, J = 7.4 Hz, 1H), 6.93 (d, J = 7.8 Hz, 2H), 5.32 (s, 1H). 13C NMR (150 MHz, CDCl3) delta 168.43, 155.72, 131.47, 129.75, 128.93, 126.92, 124.24, 118.16, 115.32, 115.09, 81.83. Anal. Calcd. for C15H11NO: C, 81.43; H, 5.01; N, 6.33. Found: C, 81.49; H, 4.99; N, 6.30.

According to the analysis of related databases, 935-02-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Du, Yan; Li, Zheng; Tetrahedron Letters; vol. 59; 52; (2018); p. 4622 – 4625;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 935-02-4, name is 3-Phenylpropiolonitrile, A new synthetic method of this compound is introduced below., Quality Control of 3-Phenylpropiolonitrile

General procedure: To a solution of cyanoacetylenes (0.4mmol) with N-tosylimines (0.2 mmol) in toluene (2 mL) was added Ph3P (0.2mmol). The mixture was then stirred at 110 C for 36 h in a reaction flask. Thenthe solvent was removed in vacuo and residue was purified by columnchromatography on silica gel to give the desired annulation product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhang, Jinfeng; Zhang, Qi; Ji, Xin; Meng, Ling-Guo; Synlett; vol. 30; 9; (2019); p. 1095 – 1099;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 935-02-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 935-02-4 as follows.

General procedure: To a solution of cyanoacetylenes (0.4mmol) with N-tosylimines (0.2 mmol) in toluene (2 mL) was added Ph3P (0.2mmol). The mixture was then stirred at 110 C for 36 h in a reaction flask. Thenthe solvent was removed in vacuo and residue was purified by columnchromatography on silica gel to give the desired annulation product.

According to the analysis of related databases, 935-02-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Jinfeng; Zhang, Qi; Ji, Xin; Meng, Ling-Guo; Synlett; vol. 30; 9; (2019); p. 1095 – 1099;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 935-02-4, name is 3-Phenylpropiolonitrile, molecular formula is C9H5N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-Phenylpropiolonitrile

4.3.1 (Z)-3-(3-Methyl-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)-3-phenyl-2-propenenitrile (3a) To a mixture of acetylene 2 (127 mg, 1 mmol) and S (32 mg, 1 mmol) was added 1-methylimidazole (1a; 82 mg, 1 mmol). The mixture was stirred at 20-25 C for 24 h. Column chromatography afforded thione 3a (132 mg, 67%), yellow microcrystalline powder, mp 159-161 C (washed with ether). Initial imidazole 1a was recovered (15 mg, conversion was 82%). 1H NMR (400.13 MHz, CDCl3): delta=7.45-7.25 [m, 5H, Ho,m,p from C(6)-Ph], 6.89 (s, 1H, 4-H), 6.80 (s, 1H, 5-H), 6.05 (s, 1H, 7-H), 3.63 (s, 3H from N-CH3) ppm. 13C NMR (100.62 MHz, CDCl3): delta=164.4 (C-2), 154.2 (C-6), 132.5 [Ci from C(6)-Ph], 131.8 [Cp from C(6)-Ph], 129.1 [Cm from C(6)-Ph], 126.8 [Co from C(6)-Ph], 119.8 (C-4), 116.9 (C-5), 114.6 (CN), 97.0 (C-7), 35.3 (N-CH3) ppm. 15N NMR (40.55 MHz, CDCl3): delta=-110.6 (CN), -207.8 (N-3), -217.9 (N-1) ppm. IR (KBr): 2220 (CN), 1621 (C=C), 1383 (C=S) cm-1. Anal. Calcd for C13H11N3S (241.31): C, 64.70; H, 4.59; N, 17.41; S, 13.29. Found: C, 64.44; H, 4.32; N, 17.72; S, 13.34.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 935-02-4, its application will become more common.

Reference:
Article; Belyaeva, Kseniya V.; Andriyankova, Ludmila V.; Nikitina, Lina P.; Mal’Kina, Anastasiya G.; Afonin, Andrei V.; Ushakov, Igor A.; Bagryanskaya, Irina Yu.; Trofimov, Boris A.; Tetrahedron; vol. 70; 5; (2014); p. 1091 – 1098;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 935-02-4, name is 3-Phenylpropiolonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Phenylpropiolonitrile

General procedure: To a solution of cyanoacetylenes (0.4mmol) with N-tosylimines (0.2 mmol) in toluene (2 mL) was added Ph3P (0.2mmol). The mixture was then stirred at 110 C for 36 h in a reaction flask. Thenthe solvent was removed in vacuo and residue was purified by columnchromatography on silica gel to give the desired annulation product.

The synthetic route of 935-02-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Jinfeng; Zhang, Qi; Ji, Xin; Meng, Ling-Guo; Synlett; vol. 30; 9; (2019); p. 1095 – 1099;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

935-02-4, name is 3-Phenylpropiolonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H5N

General procedure: To a solution of cyanoacetylenes (0.4mmol) with N-tosylimines (0.2 mmol) in toluene (2 mL) was added Ph3P (0.2mmol). The mixture was then stirred at 110 C for 36 h in a reaction flask. Thenthe solvent was removed in vacuo and residue was purified by columnchromatography on silica gel to give the desired annulation product.

The synthetic route of 935-02-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Jinfeng; Zhang, Qi; Ji, Xin; Meng, Ling-Guo; Synlett; vol. 30; 9; (2019); p. 1095 – 1099;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding some certain compound to certain chemical reactions, such as: 935-02-4, name is 3-Phenylpropiolonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 935-02-4. 935-02-4

General procedure: To a mixture of acetylene 2 (127 mg, 1 mmol) and S (32 mg, 1 mmol) was added 1-methylimidazole (1a; 82 mg, 1 mmol). The mixture was stirred at 20-25 C for 24 h. Column chromatography afforded thione 3a (132 mg, 67%), 4.3.8 (Z)-3-(3-Allyl-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)-3-phenyl-2-propenenitrile (3f) Analogously, from acetylene 2 (127 mg, 1 mmol), S (32 mg, 1 mmol), and 1-allylimidazole (1f; 108 mg, 1 mmol) (20-25 C, 24 h) thione 3f (186 mg, 87%) was obtained as a yellow microcrystalline powder, mp 140-142 C (washed with ether). Initial imidazole 1f was recovered (23 mg, conversion was 79%). 1H NMR (400.13 MHz, CDCl3): delta=7.49-7.29 [m, 5H, Ho,m,p from C(6)-Ph], 6.90 (s, 1H, 4-H), 6.80 (s, 1H, 5-H), 6.07 (s, 1H, 7-H), 6.02-5.92 (m, 1H, Hx from N-Allyl), 5.34 (d, 3JHA,Hx=10.3 Hz, 1H, HA from N-Allyl), 5.28 (d, 3JHB,Hx=17.0 Hz, 1H, HB from N-Allyl), 4.70 (d, =5.9 Hz, 2H, N-CH2 from N-Allyl) ppm. 13C NMR (100.62 MHz, CDCl3): delta=164.3 (C-2), 154.3 (C-6), 132.6 [Ci from C(6)-Ph], 132.0 [Cp from C(6)-Ph], 131.3 (CHx from N-Allyl), 129.3 [Cm from C(6)-Ph], 126.9 [Co from C(6)-Ph], 119.7 (C-4), 118.4 (CHA,HB from N-Allyl), 117.2 (C-5), 114.7 (CN), 97.3 (C-7), 50.3 (CH2 from N-Allyl) ppm. IR (KBr): 2222 (CN), 1621 (C=C), 1398 (C=S) cm-1. Anal. Calcd for C15H13N3S (267.35): C, 67.39; H, 4.90; N, 15.72; S, 11.99. Found: C, 67.26; H, 4.81; N, 15.80; S, 11.69.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Phenylpropiolonitrile.

Reference:
Article; Belyaeva, Kseniya V.; Andriyankova, Ludmila V.; Nikitina, Lina P.; Mal’Kina, Anastasiya G.; Afonin, Andrei V.; Ushakov, Igor A.; Bagryanskaya, Irina Yu.; Trofimov, Boris A.; Tetrahedron; vol. 70; 5; (2014); p. 1091 – 1098;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 935-02-4, name is 3-Phenylpropiolonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 935-02-4

General procedure: A solution of benzimidazole 1a-c (1.0 mmol) in dry acetonitrile (0.3 ml) was added to a solution of phenylcyanoacetylene (2) (127 mg, 1.0 mmol) and isothiocyanate 3a-c (1.0 mmol) in dry acetonitrile (0.2 ml). The reaction mixture was stirred at 50-55C for 12-20 h. The solvent was removed, and carbothioamides 4a-e were separated by chromatography on an alumina column using 20:4:1 chloroform-benzene-ethanol as the eluent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 935-02-4.

Reference:
Article; Andriyankova; Nikitina; Belyaeva; Mal’Kina; Afonin; Vashchenko; Smirnov; Trofimov; Chemistry of Heterocyclic Compounds; vol. 50; 6; (2014); p. 807 – 813; Khim. Geterotsikl. Soedin.; vol. 50; 6; (2014); p. 876 – 882,7;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts