Synthetic Route of 928118-07-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 928118-07-4, name is 3,4-Dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 15 : 4- [5-(3-Morpholin-4-yl-phenoxy)pyridin-2-yl] -3,4-dihydi benzo[l,4]oxazine-6-carboni rile A suspension of 4-{3-[(6-chloropyridin-3-yl)oxy]phenyl}morpholine (200mg, 0.689mmol), 3,4-dihydro-2H-benzo[l,4]oxazine-6-carbonitrile (HOmg, 0.689 mol), in’5′(dibenzylideneacetone)palladium(0) (31mg, 0.034mmol), 4,5-bis,(diphenyl- phosphino)-9,9-dimethylxanthene (30 mg, 0.068mmol) and cesium carbonate (449mg, 1.379mmol) in de-gassed 1,4-dioxane (5mL) was heated at 80C for 2 days. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (MgS04) and the solvent removed under reduced pressure. The crude product was purified by column chromatography using ethyl acetate:hexane (7:3) as the mobile phase to afford 4-[5-(3-Morpholin-4-yl-phenoxy)pyridin-2-yl]-3,4- dihydro-2H-benzo[l,4]oxazine-6-carbonitrile (HOmg, 39%) as a white solid.Mass: (ES+) 415(M+H)+ HPLC: 98.7%NMR: deltaEta ( 6-DMSO) 3.12 (4H, m), 3.72 (4H, m), 3.94 (2H, m), 4.34 (2H, m), 6.40 (1H, dd), 6.55 (1H, br s), 6.74 (1H, dd), 7.04 (1H, d), 7.22 (1H, t), 7.30 (2H, m), 7.47 (1H, dd), 7.82 (1H, d) and 8.65 (1H, d).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter; WO2011/144578; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts