Simple exploration of 92616-49-4

The synthetic route of 92616-49-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92616-49-4, name is 4-Bromo-1-naphthonitrile, A new synthetic method of this compound is introduced below., name: 4-Bromo-1-naphthonitrile

Compound B (11.60 g, 50 mmol) was dissolved in dry THF (200 mL) and stirred, and LiAlH4 (2.77 g, 73 mmol) was added slowly in portions with cooling in an ice-water bath. After completion of the addition, the reaction mixture was stirred in the ice-water bath for another 2 hours. The reaction mixture was carefully and slowly poured into stirring ice water (400 mL), stirred, and extracted with CH2Cl2 (200 mL3). The extracted organic phases were combined, washed with 5% saline solution (200 mL), and dried over anhydrous Na2SO4. The dried organic phase was evaporated on a rotary evaporator to remove the solvent, and the resulting residue was purified by column chromatography to give product C as a colorless oil. 1H NMR showed that about 30% debromination by-product (i.e., naphthalene-1-methylamine) was contained therein and a further purification was difficult, and therefore the mixture was used for the next reaction directly.

The synthetic route of 92616-49-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.; Zhao, Guilong; Liu, Changying; Liu, Yuqiang; Chen, Huihui; Li, Yuquan; Zhang, Haizhi; Xie, Yafei; Wu, Jingwei; Liu, Wei; Xu, Weiren; Zou, Meixiang; Tang, Lida; US2019/233381; (2019); A1;,
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New downstream synthetic route of 4-Bromo-1-naphthonitrile

The synthetic route of 92616-49-4 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92616-49-4, name is 4-Bromo-1-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C11H6BrN

Under N2 atmosphere, bis(pinacolato)diboron (8.4g, 33mmol), potassium acetate (6.5g, 66mmol) and [1,1?-bis(diphenylphosphine)ferrocene]palladium dichloride (1.2g, 1.76mmol) were respectively added to a solution of compound3-d (5.1g, 22mmol) in dioxane (150mL), the mixture was stirred at 80C for 6hrs. The mixture was evaporatedunder reduced pressure, the residue was filtered through celite, the filtrate cake was washed with dioxane (50mL), thefiltrate was evaporated under reduced pressure. The residue was purified with silica column chromatography (PE:EA =10:1) to give compound 3-c (6 g, yield 97%). LC-MS (ESI): m/z = 280 [M+H]+.

The synthetic route of 92616-49-4 has been constantly updated, and we look forward to future research findings.

Sources of common compounds: 4-Bromo-1-naphthonitrile

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92616-49-4, name is 4-Bromo-1-naphthonitrile, A new synthetic method of this compound is introduced below., Formula: C11H6BrN

2-[(1H-Indol-2-yl)hydrazino]acetic acid methyl ester (2.2 g), 4-bromo-1-naphthalenecarbonitrile (2.3 g), CuI (1.0 g), Cs2CO3 (3.0 g),Dimethyl glycine (500 mg) was added to DMSO (50 mL) and replaced by argon gas. The reaction was stirred at 130 C for 12 h.After cooling to room temperature, ethyl acetate and saturated water were added to separate the layers. The ethyl acetate phase was washed twice with saturated brine, dried over anhydrous sodium sulfate and filtered.Concentration under reduced pressure and purification by column chromatography (eluent: dichloromethane:methanol = 10:1, v:v) gave 0.9 g of pure product in 24% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some scientific research about 92616-49-4

According to the analysis of related databases, 92616-49-4, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 92616-49-4 as follows. Recommanded Product: 4-Bromo-1-naphthonitrile

To a solution of 4-bromo-1-naphthonitrile 10 (5g, 21.7mmol) in 1,4-dioxane and water (V:V=5:1, 100ml), was added bis(pinacolato)diboron (11g, 43.4mmol), PdCl2(dppf) (1.588g, 2.17mmol), KOAc (3.189g ,32.5mmol). The mixture was heated to 90 C and stirred for 16 h under N2. The solution was allowed to cool to room temperature and the water (200ml) was added to the solution. Then the solution was extracted with ethyl acetate (80ml¡Á3). The organic phase was combined and dried over Na2SO4, filtered, and concentrated to give crude 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthonitrile 11 (4.3g, yield = 71%), which was used without further purification.

According to the analysis of related databases, 92616-49-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yang, Xintuo; Pang, Xuehai; Fan, Lei; Li, Xinghai; Chen, Yuanwei; Bioorganic and Medicinal Chemistry Letters; vol. 27; 9; (2017); p. 1919 – 1922;,
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The origin of a common compound about 92616-49-4

The synthetic route of 4-Bromo-1-naphthonitrile has been constantly updated, and we look forward to future research findings.

Synthetic Route of 92616-49-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92616-49-4, name is 4-Bromo-1-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 4-bromo-1-naphthonitrile (230 mg, 0.991 mmol), bis(pinacolato)diboron (277 mg,1.090 mmol), potassium acetate (292 mg, 2.97 mmol) in DMSO (2 ml) was degassed and treatedwith PdC12(dppf) (21.75 mg, 0.030 mmol). The mixture was then capped and heated to 80 Covernight. The reaction mixture was then washed with water and exctracted with ethyl acetate. Theorganics were collected, dried, filtered, and concentrated. The mixture was purified by silica gel chromatography (24 G, 0-50% EtOAc-hexanes) to provide 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1-naphthonitrile as a white solid (118 mg, 43%). 1H NMR (400 MHz, Chloroform-d) 8.86-8.80 (m, 1H), 8.30-8.24 (m, 1H), 8.08 (d, J= 7.1 Hz, 1H), 7.89 (d, J 7.1Hz, 1H), 7.71 – 7.62 (m, 2H), 1.44 (s, 12H).

The synthetic route of 4-Bromo-1-naphthonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; LEE, Arthur; MCKEW, John, C.; PATEL, Paresma, R.; YU, Paul, B.; MOHEDAS, Agustin, H.; SANDERSON, Philip, E.; ZHENG, Wei; HUANG, Xiuli; UNIVERSITY OF HOUSTON SYSTEM; CUNY, Gregory, D.; (304 pag.)WO2016/11019; (2016); A1;,
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Share a compound : 92616-49-4

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92616-49-4, name is 4-Bromo-1-naphthonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 92616-49-4

19.5g (84mmol) 4-bromo-1-naphthonitrile, 5.88g (48mmol) hydroxylamine hydrochloride, 4.65g (84mmol) sodium methoxide in a methanol solvent paste has better mouth feeling and the reflux time 18. Reactants as ethyl acetate 10% sodium hydroxide aqueous solution 3 which has ethyl water insoluble chemical additives present after extracted times. Saline to which washes the 3 times during the drying process and magnesium sulfate anhydride, filtration, after concentrating dissolved back to solvent ethanol 16 doesn’t have any error frames, Raney nickel 2g the reflux time. Product to filter out removing the catalyst after concentrated within, silica gel chromatography (CHCl2/ethanol) purified after solid compound (10.0g) of 48% are obtained

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Choe, Don Soo; Jo, Yun Hwan; (92 pag.)KR2015/80966; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts