Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92616-49-4, name is 4-Bromo-1-naphthonitrile, A new synthetic method of this compound is introduced below., name: 4-Bromo-1-naphthonitrile
Compound B (11.60 g, 50 mmol) was dissolved in dry THF (200 mL) and stirred, and LiAlH4 (2.77 g, 73 mmol) was added slowly in portions with cooling in an ice-water bath. After completion of the addition, the reaction mixture was stirred in the ice-water bath for another 2 hours. The reaction mixture was carefully and slowly poured into stirring ice water (400 mL), stirred, and extracted with CH2Cl2 (200 mL3). The extracted organic phases were combined, washed with 5% saline solution (200 mL), and dried over anhydrous Na2SO4. The dried organic phase was evaporated on a rotary evaporator to remove the solvent, and the resulting residue was purified by column chromatography to give product C as a colorless oil. 1H NMR showed that about 30% debromination by-product (i.e., naphthalene-1-methylamine) was contained therein and a further purification was difficult, and therefore the mixture was used for the next reaction directly.
The synthetic route of 92616-49-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.; Zhao, Guilong; Liu, Changying; Liu, Yuqiang; Chen, Huihui; Li, Yuquan; Zhang, Haizhi; Xie, Yafei; Wu, Jingwei; Liu, Wei; Xu, Weiren; Zou, Meixiang; Tang, Lida; US2019/233381; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts