Application of 916792-09-1,Some common heterocyclic compound, 916792-09-1, name is 2-Bromo-4-fluoro-6-methylbenzonitrile, molecular formula is C8H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Bromo-4-fluoro-6-methyl-benzonitrile (IX) (0.428 g, 2 mmol) was heated in 70% aqueous sulfuric acid (2 mL)overnight at 150 00 The reaction mixture was poured into ice and extracted with ethyl acetate (4 x 2 mL). The organic phase was washed with water (4 x 2 mL), brine (2 x 2 mL), dried over Na2SO4, filtered and concentrated to give 300 mg of crude 2-bromo-4-fluoro-6-methyl-benzamide (VIII). Pure sample was obtained by recrystallization from benzene. 1H NMR (400.5 MHz, DMSO-d6) ppm 3.31 (s, 3H), 7.17 (dd, JH-F = 9.8 Hz, JH-H 2.2 Hz, 1H), 7.41 (dd, JH-F 8.6Hz, JH-H = 2.2 Hz, 1H), 7.89 (br. s, 1H), 7.65 (br. s, 1H).
The synthetic route of 916792-09-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; PAPEO, Gianluca Mariano Enrico; KRASAVIN, Mikhail Yurievitch; ORSINI, Paolo; SCOLARO, Alessandra; WO2014/64149; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts