Category: 915394-29-5

Reference of 915394-29-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915394-29-5, name is 2-(3-Aminophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows.

Example 25; l-[3-(Cyano-dimethyl-methyl)-phenyl]- 3-{4-[2-(3-hydroxy-propylamino)- pyrimidin-4-yloxy]-phenyl}-urea196 mg (1.21 mmol) l.l’-Carbonyl-diimidazol (CDI) were given to a solution of 176 mg (l.lOmmol) 3-(cyano-dimethyl-methyl)-phenylamine in 4.0 ml dichloro- methane and stirred for 12 h. A solution of 286 mg (1.10 mmol) 3-[4-(4-Amino- phenoxy)-pyrimidin-2-ylamino]-propan-l-ol in 6 ml dichloromethane was added within 30 min. and the mixture stirred for 12 h at r.t. The reaction mixture was evaporated and the residue was purified by chromatography on silica gel ( dichloromethane/ ethanol 96:4). The obtained material was leached with ether, filtered and dried. Yield 74 mg (15%) of the title compound. MS: 447.38 (ESI+), 445.32 (ESI-).eta-NMR(400Hz, [DJDMSO): delta = 1.59(br, 2H, CH2-CH2-CH2), 1.68(s, 6H, CH3), 3.2(br, 2H, CH2-NH), 3.39(br, 2H, CH2-OH), 4.38(br, IH, OH), 6.06(br, IH, 5-H- pyrimidine), 7.05(br, IH, CH2NH), 7.10(m, 3H, 3-H/5-H -Ar-NH, 4-H-Ar-C-CN),7.34(t, IH, 5-H-Ar-C-CN), 7.42(d, IH, 6-H-Ar-C-CN), 7.48(d, 2H, 2-H/6-H-Ar- NH), 7.66(s, IH, 2-H-Ar-C-CN), 8.12(d, IH, 6-H-pyrimidine), 8.72(s, IH, urea- NH), 8.84(s, IH, urea-NH).

The chemical industry reduces the impact on the environment during synthesis 2-(3-Aminophenyl)-2-methylpropanenitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/77548; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 915394-29-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915394-29-5, name is 2-(3-Aminophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows.

Example 25; l-[3-(Cyano-dimethyl-methyl)-phenyl]- 3-{4-[2-(3-hydroxy-propylamino)- pyrimidin-4-yloxy]-phenyl}-urea196 mg (1.21 mmol) l.l’-Carbonyl-diimidazol (CDI) were given to a solution of 176 mg (l.lOmmol) 3-(cyano-dimethyl-methyl)-phenylamine in 4.0 ml dichloro- methane and stirred for 12 h. A solution of 286 mg (1.10 mmol) 3-[4-(4-Amino- phenoxy)-pyrimidin-2-ylamino]-propan-l-ol in 6 ml dichloromethane was added within 30 min. and the mixture stirred for 12 h at r.t. The reaction mixture was evaporated and the residue was purified by chromatography on silica gel ( dichloromethane/ ethanol 96:4). The obtained material was leached with ether, filtered and dried. Yield 74 mg (15%) of the title compound. MS: 447.38 (ESI+), 445.32 (ESI-).eta-NMR(400Hz, [DJDMSO): delta = 1.59(br, 2H, CH2-CH2-CH2), 1.68(s, 6H, CH3), 3.2(br, 2H, CH2-NH), 3.39(br, 2H, CH2-OH), 4.38(br, IH, OH), 6.06(br, IH, 5-H- pyrimidine), 7.05(br, IH, CH2NH), 7.10(m, 3H, 3-H/5-H -Ar-NH, 4-H-Ar-C-CN),7.34(t, IH, 5-H-Ar-C-CN), 7.42(d, IH, 6-H-Ar-C-CN), 7.48(d, 2H, 2-H/6-H-Ar- NH), 7.66(s, IH, 2-H-Ar-C-CN), 8.12(d, IH, 6-H-pyrimidine), 8.72(s, IH, urea- NH), 8.84(s, IH, urea-NH).

The chemical industry reduces the impact on the environment during synthesis 2-(3-Aminophenyl)-2-methylpropanenitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/77548; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 915394-29-5,Some common heterocyclic compound, 915394-29-5, name is 2-(3-Aminophenyl)-2-methylpropanenitrile, molecular formula is C10H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoic acid (8.95g, 31mmol) was stirred in a solvent of 58 dimethyl formamide (25mL).The reaction solution was added with 59 HATU (12.98g, 34.1mmol), 72 DIPEA (10.26mL, 62.0mmol) and 104 3-(trifluoromethyl)aniline (5g, 31mmol), followed by stirring for about 8h at room temperature. The reaction mixture was diluted with ethyl acetate and washed with a saturated aqueous sodium bicarbonate solution and saline. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting mixture was concentrated to give the crude 132 product, which was purified by silica gel column chromatography.

The synthetic route of 915394-29-5 has been constantly updated, and we look forward to future research findings.

Reference of 915394-29-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915394-29-5, name is 2-(3-Aminophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows.

FIG. 3C shows a modification of Scheme 1 (e.g., Scheme 1A), which uses a different Ring A reactant that results in the Ring A of the product being the structure of Compound 115. Accordingly, variations of Scheme 1 can be implemented to generate the other compounds that fall under Formula A and/or Formula B.Compound 115 is confirmed by the following spectral data: the yellow solid of Compound 115 (37.82 mg, 83.63 u mol, 34.89% yield, 95.630% purity) was confirmed by 1HNMR(EW13467-173-P1A), CNMR(EW13467-173-P1B), LCMS(EW13467-173-P1B) and HPLC(EW13467-173-P1B); LCMS: Retention time: 1.021 min, (M+H)=433.3, 5-95AB_R_220&254.1 cm. EW13467-173-P1B; HPLC: Retention time: 2.403 min, 10-80AB_4min.1 cm. EW13467-173-P1B; NMR: 1H NMR (400 MHz, DMSO-d6) ppm=9.79 (s, 1H), 8.75 (br d, J =4.0 Hz, 1H), 8.28 (br d, J =8.9 Hz, 2H), 8.09 (d, J =8.1 Hz,1H), 7.88 (s, 1H), 7.76-7.67 (m, 1H), 7.48-7.34 (m, 3H), 7.13 (br d, J =7.7 Hz, 1H), 2.69 (s, 3H), 1.72 (s, 6H).

The chemical industry reduces the impact on the environment during synthesis 2-(3-Aminophenyl)-2-methylpropanenitrile. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915394-29-5, name is 2-(3-Aminophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-(3-Aminophenyl)-2-methylpropanenitrile

3-((7H-pyrrolor2,3-dlpyrimidin-4-yl)oxy)-N-(3-(2-cyanopropan-2-yl)phenyl)-4- methylbenzamide (1-11): To a solution of 4-methyl-3-((7-((2-(trimethylsilyl)ethoxy)methyl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)benzoic acid (200 mg, 0.5 mmol), HATU (230 mg, 0.6 mmol), DMAP (73 mg, 0.6 mmol) and iPr2NEt (220 uL, 1.25 mmol) in CH2C12 (3 mL) was added 2-(3-aminophenyl)-2-methylpropanenitrile (80 mg, 0.5 mmol) and the resulting mixture was stirred at room temperature for 24 hours. The solution was filtered to remove solids, concentrated and purified with column chromatography (dichloromethane : methanol = 10: 1) to afford 455 mg of product as a colorless oil. To the solution of the obtained oil in CH2CI2 (5 mL) was added TFA (0.5 mL) and the resulting mixture was stirred at room temperature for 5 hours. The solution was concentrated and dried with vacuum, then dissolved in THF (4 mL) and 1 N NaOH solution (4 mL). The reaction mixture was stirred for 24 h and extracted with ethyl acetate. The combined organic phase was washed with brine and dried with Na2S04, then filtered and concentrated, and purified by reverse phase HPLC to give 185 mg (90%) of title compound as a white solid.

According to the analysis of related databases, 915394-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; TREON, Steven, P.; BUHRLAGE, Sara, Jean; GRAY, Nathanael; TAN, Li; YANG, Guang; WO2015/89479; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts