Category: 914637-31-3

Application of 914637-31-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 914637-31-3 as follows.

4.2 g (181 mmol) of sodium in small pieces were added gradually to a solution of25 g (151 mmol) of(3-fluoro-5-methoxyphenyl)-acetonitrile in 200 mL of diethyl carbonate in such a manner that the temperature remained at approximately 100C.Thereafter, the reaction mixture was heated to reflux for 1 hr. After evaporation under reduced pressure, the mixture was treated with cooled water. The solution was acidifiedwith acetic acid and extracted with EA. The combined organic extracts were dried andevaporated. The residue was purified by silica gel (EA: PE/1 :10) to give 23 g of the title compound as light brown oil (yield: 64%).LC-MS: m/z 238 (M+H); RT=1.72 min/2.5 min.

According to the analysis of related databases, 914637-31-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBVIE DEUTSCHLAND GMBH & CO. KG; ABBVIE INC.; GENESTE, Herve; OCHSE, Michael; DRESCHER, Karla; JAKOB, Clarissa; WO2014/27078; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 914637-31-3,Some common heterocyclic compound, 914637-31-3, name is 2-(3-Fluoro-5-methoxyphenyl)acetonitrile, molecular formula is C9H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2-(3-fluoro-5-methoxyphenyl)acetonitrile (2.62 g, 16 mmol) in MeOH:H20 (1 :1; 15 mL), NaOH (1.28 g, 32 mmol) was added. Then the mixture was stirred at 65 C for 4 h. The mixture was cooled to room temperature, and 4M aqueous HCl solution was added until the pH was adjusted to 4~5. The mixture was filtered and the solid obtained was washed with H20 (2 x 5 mL) to give 2.33 g of 2-(3-fluoro-5-methoxyphenyl)acetic acid. H NMR (CDC13): delta 6.52-6.62 (m, 3H), 3.78 (s, 3H), 3.59 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(3-Fluoro-5-methoxyphenyl)acetonitrile, its application will become more common.

Reference:
Patent; ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.; WO2011/156518; (2011); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts