Adding a certain compound to certain chemical reactions, such as: 91132-15-9, name is 2-(4-(Hydroxymethyl)phenyl)-2-methylpropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 91132-15-9, Safety of 2-(4-(Hydroxymethyl)phenyl)-2-methylpropanenitrile
a- Synthesis of Int. 51 : To a suspension of 7 (2.5 g, 1 1 .3 mmol ), 2-[4-(hydroxymethyl)phenyl]-2- methylpropanenitrile (1.8 g, 10.3 mmol ), PPh3 supp (3.8 g, 12.3 mmol ) in d y DCM (50 mL) was added DBAD (2.8 g, 12.3 mmol) and the r.m. was stirred at r.t. for 18 h. The mixture was filtered through Celite, washed with DCM and the filtrate was evaporated until dryness. The residue (7g) was purified by prep. LC (irregular SiOH 35-40muiotaeta, 90g GraceResolv, gradient from 95% heptanes, 5% EtOAc to 80% heptanes, 20%> EtOAc). The fractions were collected and evaporated until dryness to give 2. lg of Int. 51 (54%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-(Hydroxymethyl)phenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; MEVELLEC, Laurence, Anne; PASQUIER, Elisabeth, Therese, Jeanne; DESCAMPS, Sophie; MERCEY, Guillaume, Jean, Maurice; WROBLOWSKI, Berthold; VIALARD, Jorge, Eduardo; MEERPOEL, Lieven; JEANTY, Matthieu, Ludovic; JOUSSEAUME, Thierry, Francois, Alain, Jean; WO2015/144799; (2015); A1;,
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