Related Products of 91054-33-0, These common heterocyclic compound, 91054-33-0, name is 2-Acetylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 10 mL thick-walled pressure-resistant tube, combine 2-acetylbenzonitrile (100 mg, 0.69 mmol), copper acetylacetonate (36 mg, 0.14 mmol), ethyl isocyanoacetate (91 muL, 0.83 mmol) and 1 , 8-Diazabicycloundec-7-ene (124 muL, 0.83 mmol), added to stirred acetonitrile (2 mL) in sequence, and reacted at 85 C. for 12 hours to complete the reaction, dried on a rotary evaporator The solvent was subjected to column chromatography to obtain a pale yellow solid (31.6 mg, 20%).
The synthetic route of 91054-33-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lanzhou University; Wang Shaohua; Bao Wen; Zhang Banghong; (6 pag.)CN110627720; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts