Category: 91-15-6

Grigor’eva, A. I. published the artcileSynthesis and Antimonoamine Oxidase Activity of 2-(3-Iminoisoindol-1-ylidene)-2-arylacetonitriles, Recommanded Product: Phthalonitrile, the main research area is oxoisoindolylidene arylacetonitrile preparation; iminoisoindolylidene arylacetonitrile preparation diastereoselective hydrolysis antimonoamine oxidase activity; phthalonitrile arylacetonitrile cascade condensation.

A one-pot synthesis of 2-(3-iminoisoindol-1-ylidene)-2-arylacetonitriles (E)-I (Ar = Ph, 3-chlorophenyl, 4-methylphenyl, 4-methoxyphenyl, 1-naphthyl; X = NH) in yields of up to 95% by the cascade condensation of phthalonitrile with arylacetonitriles ArCH2CN in a superbasic NaOH/DMSO medium was proposed. A method for the synthesis of (E)-2-(3-oxoisoindol-1-ylidene)-2-arylacetonitriles I (X = O) by the hydrolysis of 2-(3-iminoisoindol-1-ylidene)-2-arylacetonitriles I (X = NH) in acetic acid was developed. The obtained (E)-2-(3-iminoisoindol-1-ylidene)-2-arylacetonitriles I (X = NH) were shown to be active inhibitors of human monoamine oxidase [IC50 (MAO-A) for I (Ar = 4-methylphenyl, X = NH) 3.26μM].

Russian Journal of Organic Chemistry published new progress about Condensation reaction, stereoselective. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Baechle, Felix published the artcileGlycoconjugated Phthalocyanines as Photosensitizers for PDT – Overcoming Aggregation in Solution, Synthetic Route of 91-15-6, the main research area is glycoconjugated zinc phthalocyanine complex preparation CD spectra fluorescence; cytotoxicity activity glycoconjugated zinc phthalocyanine complex.

A series of new glycoconjugated zinc(II) phthalocyanines (Pcs) was synthesized and fully characterized. The major focus of the structural design for these new Pcs was upon the reduction of aggregate formation in solution Therefore, the aglycons of the Pc-linked sugars, the number and the position of the carbohydrate substituents on the Pc and the linker between sugar and Pc were varied. Specifically, di- and octasubstituted zinc(II) phthalocyanines with triazole and C-C linkages were synthesized and their aggregation behavior was investigated by UV/visible-, CD- and NMR spectroscopy. The C-glycosidically decorated Pcs described here are the first compound types of this kind. These C-glycosidically substituted Pcs not form any aggregation in solution and hence, are considered to be potential photosensitizers in photodynamic therapy. All Pcs synthesized in this study exhibited excellent photophys. properties for use as photosensitizers (λmax > 675 nm with εmax > 105 M-1 cm-1). Preliminary cytotoxicity studies of the Pcs presented here showed that all Pcs are photodynamically effective.

European Journal of Organic Chemistry published new progress about Circular dichroism. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chlupaty, Tomas published the artcileReversible addition of tin(II) amides to nitriles, Related Products of nitriles-buliding-blocks, the main research area is tin silylamide reaction nitrile dinitrile trinitrile; amidotin amidinate preparation crystal mol structure; magnesium lanthanum benzamidinate preparation; crystal mol structure amidotin amidinate.

Lappert’s stannylene (Sn[N(SiMe3)2]2) has been reacted with various nitriles, dinitriles and trinitriles with the formation of heteroleptic amidotin(II) amidinates of the general formulas [RC(NSiMe3)2]SnN(SiMe3)2, R'{[C(NSiMe3)2]SnN(SiMe3)2}2 and R”{[C(NSiMe3)2]SnN(SiMe3)2}3, where R = Ph (1), 2-(CN)-C6H4 (2), 3-(CN)-C6H4 (3); R’ = 1,3-C6H4 (4), 1,4-C6H4 (5) and R” = 1,3,5-C6H3 (6). The reactions of amidotin(II) benzamidinate 1 with an excess of benzonitrile proceed to homoleptic tin(II) bis(benzamidinate) [PhC(NSiMe3)2]2Sn, which reversibly eliminates benzonitrile and 1 when warmed. The premise of reversibility has been supported by a multinuclear time-dependent NMR study and a theor. (DFT) description. On the other hand, magnesium(II) bis(benzamidinate) [PhC(NSiMe3)2]2Mg (8) and lanthanum(II) tris(benzamidinate) [PhC(NSiMe3)2]3La (7) have been synthesized from appropriate metal hexamethyldisilazides and benzonitrile.

Dalton Transactions published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts