Adding a certain compound to certain chemical reactions, such as: 905710-66-9, name is 4-Bromo-3-(hydroxymethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 905710-66-9, Formula: C8H6BrNO
To a solution of 4-bromo-3-(l -hydroxy ethyl)benzonitrile (0.95 g, 0.0045 mol) in dichloromethane (CH2CI2; 10 mL) at 0 C were added NN-diisopropylethylamine (DIPEA; 2.0 g, 0.0157 mol) and methyl chloromethyl ether (MOMCl; 0.72 g, 0.009 mol) slowly. The resulting mixture was stirred at room temperature overnight. The reaction mass was quenched with H2O and extracted with CH2CI2. The organic layer was washed with H2O and brine, dried over Na2S04 and concentrated to provide the crude product. Purification by flash column chromatography (S1O2; gradient of 0-15 % EtOAc in hexane) gave the title compound as a colorless oil (1 g, 90%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(hydroxymethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DOW AGROSCIENCES LLC; BRAVO-ALTAMIRANO, Karla; CASTELLO, Olena; GRUBER, Joseph M.; MARKLEY, Lowell; RIAR, Dilpreet S.; ROTH, Joshua; YAP, Maurice C.; (62 pag.)WO2018/156554; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts