Category: 90433-20-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 90433-20-8, name is 2-(3-Bromophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., Product Details of 90433-20-8

Step 2. A solution of 2-(3-bromo-phenyl)-2-methyl-propionitrile [0.5 g, 2.2 mmol, Intermediate (65)] in toluene (8 mL) and THF (2 mL) is added triisopropyl borate (0.61 mL, 2.68 mmol) at -780C. tert- Butyl lithium (1.7 M in pentane, 1.55 mL, 2.68 mmol) is added dropwise during 15 min. Reaction mixture is stirred at -78C for additional 1 hour, warmed up to -2O0C and quenched with 2N hydrochloric acid (10 mL). The reaction mixture is extracted with ether, combined ether layers are washed with brine, dried and concentrated to obtain 3-fcyano-dimethyl-methyl’)-phenyl boronic acid (0.5 g) [Intermediate (66)] as an oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/44732; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 90433-20-8, name is 2-(3-Bromophenyl)-2-methylpropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90433-20-8, Recommanded Product: 2-(3-Bromophenyl)-2-methylpropanenitrile

General procedure: To a mixture of compound 5 (2.00 g, 12.3 mmol), X-Phos (0.292 g, 0.613 mmol), sodium tert-butoxide (2.94 g, 30.6 mmol) and tris(dibenzylidineacetone)dipalladium (0.224 g, 0.245 mmol) in 1,4-dioxane (25 mL) was added 4-bromoanisole (1.6 mL, 12.9 mmol) and heated to 100 C for 2 h. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and concentrated in vacuo. The residue was powdered from diethyl ether to give the title compound (2.02 g, 61%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Bromophenyl)-2-methylpropanenitrile, and friends who are interested can also refer to it.

Reference:
Article; Mochizuki, Michiyo; Kori, Masakuni; Kono, Mitsunori; Yano, Takahiko; Sako, Yuu; Tanaka, Maiko; Kanzaki, Naoyuki; Gyorkos, Albert C.; Corrette, Christopher P.; Aso, Kazuyoshi; Bioorganic and Medicinal Chemistry; vol. 24; 19; (2016); p. 4675 – 4691;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts