Category: 89245-35-2

See, Cheng Shang; Kitagawa, Mayumi; Liao, Pei-Ju; Lee, Kyung Hee; Wong, Jasmine; Lee, Sang Hyun; Dymock, Brian W. published their research in European Journal of Medicinal Chemistry on August 5 ,2018. The article was titled 《Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131)》.Application of 89245-35-2 The article contains the following contents:

Selective targeting of cancer cells over normal cells is a key objective of targeted therapy. However few approaches achieve true mechanistic selectivity resulting in debilitating side effects and dose limitation. In this work we describe the discovery of A131 (4a), a new agent with an unprecedented dual mechanism of action targeting both mitosis and autophagy. Compound 4a was first identified in a phenotypic screen in which HeLa cells treated with 4a manifested mitotic arrest along with formation of multiple vesicles. Further investigations showed that 4a causes an increase in mitotic marker pH3 and autophagy marker LC3. Importantly 4a induces cell death in cancer cells while sparing normal cells which regrow after 4a is removed. Dual activities against pH3 and LC3 markers are required for cancer cell selectivity. An extensive SAR investigation confirmed 4a as the optimal dual inhibitor with potency against a panel of 30 cancer cell lines (average antiproliferative GI50 1.5μM). In a mouse model of paclitaxel-resistant colon cancer, 4a showed 74% tumor growth inhibition when administered at a dose of 20mg/kg IP twice a day. After reading the article, we found that the author used 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Application of 89245-35-2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Application of 89245-35-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C10H7BrN2On November 3, 1993 ,《Novel applications of vinylogous Mannich reactions. Total synthesis of rugulovasines A and B》 appeared in Journal of the American Chemical Society. The author of the article were Martin, Stephen F.; Liras, Spiros. The article conveys some information:

The total syntheses of the Ergot alkaloids rugulovasines A (I, R = MeNH, R1 = H) and B (R = H, R1 = MeNH) were completed in a concise sequence requiring only eight reactions from com. available 4-bromoindole. The two key steps of the synthesis were the vinylogous Mannich reaction of the iminium salt of II with the furan III and the cyclization of IV by a SRN1 reaction. Thus, 4-bromoindole was converted in a straightforward manner to the 3-acetaldehyde derivative, which after treatment with benzylmethylamine provided the intermediate enamine II. Treatment of II with silyloxyfuran III in the presence of acid produced IV via a vinylogous Mannich reaction. A photostimulated SRN1 reaction of IV was employed to construct the spirocyclic lactone moiety followed by hydrogenolysis gave rugulovasines A and B. The experimental process involved the reaction of 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2COA of Formula: C10H7BrN2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.COA of Formula: C10H7BrN2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mao, Qiu-Xia; Zhang, Chen-Guang; Li, Jin-Feng published their research in Acta Crystallographica, Section E: Structure Reports Online on February 29 ,2012. The article was titled 《2-(4-Bromo-1H-indol-3-yl)acetonitrile》.Product Details of 89245-35-2 The article contains the following contents:

In the title compound, C10H7BrN2, the non-H atoms, except the N atom of the acetonitrile group and the C atom bonded to it, lie in the least-squares plane defined by the atoms of the indole ring system (r.m.s deviation = 0.019 Å), with the N and C atom of the cyano group displaced by 2.278 (1) and 1.289 (1) Å, resp., out of that plane. In the crystal, N-H···N hydrogen bonds link the mols. into a C(7) chain along [100]. Crystallog. data are given.2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Product Details of 89245-35-2) was used in this study.

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Product Details of 89245-35-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts