Category: 886761-96-2

Zhang, Wei; Tao, Shanqing; Ge, Huaibin; Li, Qiao; Ai, Zhenkang; Li, Xiaoxian; Zhang, Beibei; Sun, Fengxia; Xu, Xiaqing; Du, Yunfei published the artcile< Construction of 2-Arylbenzo[4,5]thieno[2,3-d]thiazole Skeleton via CuCl/S-Mediated Three-Component Reaction>, Quality Control of 886761-96-2, the main research area is arylbenzothienothiazole derivative preparation; bromophenylacetonitrile arylaldehyde sulfur three component reaction copper chloride.

An exclusive thiophene-fused polycyclic π-conjugated 2-arylbenzo[4,5]thieno[2,3-d]thiazole skeleton was constructed via a one-pot CuCl-mediated three-component reaction, using 2-(2-bromophenyl)acetonitrile and aromatic aldehydes as substrates and elemental sulfur as sulfur source in the presence of K2CO3 and 1,10-phenanthroline in DMSO. A plausible reaction mechanism was proposed, which involved formation of benzo[b]thiophen-2-amines through cyclization of 2-bromophenyl acetonitrile and sulfur, and subsequent intramol. condensation/dehydrogenation with aromatic aldehydes.

Organic Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Quality Control of 886761-96-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Carny, Tomas; Rocaboy, Ronan; Clemenceau, Antonin; Baudoin, Olivier published the artcile< Synthesis of Amides and Esters by Palladium(0)-Catalyzed Carbonylative C(sp3)-H Activation>, Reference of 886761-96-2, the main research area is amide ester preparation palladium catalyst carbonylative activation alkoxycarbonylation aminocarbonylation; C−H activation; amides; carbonylation; domino reactions; palladium.

The 1,4-palladium shift strategy allows the functionalization of remote C-H bonds that are difficult to reach directly. Reported here is a domino reaction proceeding by C(sp3)-H activation, 1,4-palladium shift, and amino- or alkoxycarbonylation, which generates a variety of amides and esters bearing a quaternary β-carbon atom. Mechanistic studies showed that the aminocarbonylation of the σ-alkylpalladium intermediate arising from the palladium shift is fast using PPh3 as the ligand, and leads to the amide rather than the previously reported indanone product.

Angewandte Chemie, International Edition published new progress about Alkoxycarbonylation. 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Reference of 886761-96-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Park, Kyeong-Yong; Lee, Jinyong; Park, Seong Jun; Heo, Jung-Nyoung; Lim, Hwan Jung published the artcile< Regioselective Synthesis of 1,2- and 1,4-Dihydroquinolines by Palladium-Catalyzed Intramolecular N-Arylation>, Related Products of 886761-96-2, the main research area is bromoaryl enamine palladium intramol arylation catalyst; dihydroquinoline regioselective preparation.

A series of 1,2- and 1,4-dihydroquinolines has been successfully prepared The Pd-catalyzed intramol. N-arylation of Z-enamines, formally prepared by the Horner-Wadsworth-Emmons olefination, proceeded efficiently to furnish the cyclized products. Depending on the cyclization conditions, substituted 1,4-dihydroquinolines and further isomerized 1,2-dihydroquinolines were independently obtained in high yields with an excellent control of isomerization of the double bond.

Advanced Synthesis & Catalysis published new progress about Arylation (intramol.). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Related Products of 886761-96-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Martin, Nicolas; Pierre, Cathleen; Davi, Michael; Jazzar, Rodolphe; Baudoin, Olivier published the artcile< Diastereo- and Enantioselective Intramolecular C(sp3)-H Arylation for the Synthesis of Fused Cyclopentanes [Erratum to document cited in CA157:076425]>, COA of Formula: C8H5BrFN, the main research area is erratum indane stereoselective preparation; intramol arylation bromoisobutylbenzene palladium binepine catalyst erratum.

On pages 4482, Scheme 2 and Figure 1 contained an incorrect absolute configuration; the corrected scheme and figure are given.

Chemistry – A European Journal published new progress about Arylation (intramol.). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, COA of Formula: C8H5BrFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhan, Linjun; Hu, Wei; Wang, Mei; Huang, Bin; Long, Yaqiu published the artcile< Imidoyl chloride mediated one-pot synthesis of 3-electron withdrawing group substituted indoles>, Computed Properties of 886761-96-2, the main research area is imidoyl chloride electron withdrawing group substituted indole synthesis.

Indole scaffold is widely present in pharmaceutical and pesticide products, dyes and natural products. The indole skeleton substituted by the electron withdrawing group at position 3 is an important class of bioactive indole derivatives Among them, 3-cyanoindole is a key module in the construction of privileged scaffold-based combinatory library and diversity-oriented synthesis for drug discovery. For these reasons, the design and synthesis of these scaffolds have received considerable attention in organic synthesis and have been extensively studied. However, the cyano group on the indole was introduced directly in previously reported methods. Due to the high toxicity of cyanide, the application of these reactions is limited. Imidoyl chloride, a highly reactive synthon, which was successfully used as a module for the construction of quinolones, quinazolines, benzimidazoles and other drug-like privileged scaffolds by our group. By making use of the imidoyl chloride as the active intermediate to mediate a cascade reaction to form the heterocycle, we developed a new one-pot synthesis to construct the 3-cyano or carboxylate-indole derivatives The reaction proceeded via two sequential steps: initial formation of imidoyl chloride starting from N-substituted arylamide and thionyl chloride, followed by 2-bromo-arylnitrile carbanion nucleophilic addition, elimination and Ulmann reaction. This synthetic methodol. is featured with cheap and readily available starting materials, high reaction yields, high functional group tolerance and broad substrate scope. This reaction is a direct synthesis not requiring prefunctionalization, and highly atom- and step-economic. It’s worth noting that it’s the first time building 3-cyanoindole scaffold commenced with the substrates bearing cyano group, which is of great importance for avoiding potential safety hazards.

Huaxue Xuebao published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Computed Properties of 886761-96-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Martin, Nicolas; Pierre, Cathleen; Davi, Michael; Jazzar, Rodolphe; Baudoin, Olivier published the artcile< Diastereo- and Enantioselective Intramolecular C(sp3)-H Arylation for the Synthesis of Fused Cyclopentanes>, Product Details of C8H5BrFN, the main research area is indane stereoselective preparation intramol arylation bromoisobutylbenzene palladium binepine catalyst.

The diastereo- and enantioselective synthesis of indanes and some heterocyclic analogs by intramol. C(sp3)-H arylation of 1-bromo-2-isobutylbenzenes using a chiral Pd-binepine catalyst is reported.

Chemistry – A European Journal published new progress about Arylation (intramol.). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Product Details of C8H5BrFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hou, Chuanwei; He, Qian; Yang, Chunhao published the artcile< Direct Synthesis of Diverse 2-Aminobenzo[b]thiophenes via Palladium-Catalyzed Carbon-Sulfur Bond Formation Using Na2S2O3 as the Sulfur Source>, SDS of cas: 886761-96-2, the main research area is diverse aminobenzothiophene synthesis palladium catalyzed carbon sulfur bond formation; sodium thiosulfate sulfur source aminobenzothiophene synthesis.

A novel and direct synthesis of various 2-aminobenzo[b]thiophenes has been developed. The reactions were catalyzed by a combination of Pd(dppf)Cl2 and dppf using odorless and cheap Na2S2O3 as the sulfur source. This strategy allowed us to synthesize important 2-aminobenzo[b]thiophene scaffold more efficiently and conveniently. Thus, e.g., sulfuration of (2-bromophenyl)acetonitrile with Na2S2O3 in presence of Pd(dppf)Cl2 and dppf afforded 2-aminobenzothiophene in up to 64% yield.

Organic Letters published new progress about Acetylation (nucleophilic substitution of dimethylamine formed in situ from DMF under attempted acetylation conditions). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, SDS of cas: 886761-96-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wan, Bin; Lu, Zhuoer; Wu, Zhuo; Cheng, Cang; Zhang, Yanghui published the artcile< Diastereoselective Construction of Eight-Membered Carbocycles through Palladium-Catalyzed C(sp3)-H Functionalization>, COA of Formula: C8H5BrFN, the main research area is alkylphenyl bromide biphenylene palladium catalyst diastereoselective cross coupling reaction; dihydrotribenzoannulene preparation.

A palladium-catalyzed cross-coupling reaction of 2-alkylphenyl bromides with biphenylene was developed. The reactions formed eight-membered carbocycles through C(sp3)-H activation and the formation of two C-C bonds, and the chiral products were obtained with excellent diastereoselectivity. The reaction provided a new strategy for the construction of eight-membered carbocycles, and the products represent a novel type of chiral scaffold.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, COA of Formula: C8H5BrFN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chatterjee, Arpita; Murmu, Chudamani; Peruncheralathan, S. published the artcile< Copper-catalysed N-arylation of 5-aminopyrazoles: a simple route to pyrazolo[3,4-b]indoles>, Recommanded Product: 2-(2-Bromo-5-fluorophenyl)acetonitrile, the main research area is phenylaminopyrazole preparation copper catalyst arylation; phenyl pyrazoloindole preparation.

A copper-catalyzed intramol. N-arylation of 5-aminopyrazoles is demonstrated for the first time. Highly substituted pyrazolo[3,4-b]indoles were synthesized. In particular, the indole core was decorated with halogens and alkyl and methoxy groups. Furthermore, a selective N-arylation of unsym. diaryl bromide containing pyrazoles was exemplified, resulting in valuable pyrazolo[1,5-a]benzimidazoles.

Organic & Biomolecular Chemistry published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Recommanded Product: 2-(2-Bromo-5-fluorophenyl)acetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Flores-Gaspar, Areli; Martin, Ruben published the artcile< Mechanistic Switch via Subtle Ligand Modulation: Palladium-Catalyzed Synthesis of α,β-Substituted Styrenes via C-H Bond Functionalization>, Recommanded Product: 2-(2-Bromo-5-fluorophenyl)acetonitrile, the main research area is palladium catalyst aldehyde bromophenylmethyl olefination; alkene aryl preparation.

A new catalyst system for the efficient use of aldehydes I [R1 = H, F, MeO, etc.; R2 = H, Cl, etc.; R3 = H, 3-HO, 3,5-Me2, etc.] for the synthesis of styrenes II via C-H bond functionalization and a subtle ligand modification is described. The high level of activity achieved allows to synthesize highly functionalized α,β-substituted styrenes, even the elusive E-configured trisubstituted olefins, in a regio- and stereoselective manner. Mechanistic experiments allowed to identify the corresponding synthetic intermediates.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Recommanded Product: 2-(2-Bromo-5-fluorophenyl)acetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts