Electric Literature of 886500-41-0,Some common heterocyclic compound, 886500-41-0, name is 4-Chloro-2,6-difluorobenzonitrile, molecular formula is C7H2ClF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 4-chloro-2,6-difluorobenzonitrile (1.66 g, 9.56 mmol), pyrrole (0.67 g, 10 mmol) and Cs2CO3 (3.7 g, 12 mmol) in DMF (20 ml) was stirred overnight. Then, the solid was filtered off and the solvent was removed by reduced pressure. The residue was purified by column chromatography over silica gel (eluent: EtOAc/petroleum ether 10/1). The desired fractions were collected and the solvent was evaporated. Yield: 1.1 g of intermediate 15 (15% yield; white solid).
The synthetic route of 886500-41-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Meerpoel, Lieven; Maes, Louis Jules Roger Marie; de Wit, Kelly; US2013/85136; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts