Category: 882978-62-3

On February 1, 2007, Ng, Raymond A.; Guan, Jihua; Alford, Vernon C.; Lanter, James C.; Allan, George F.; Sbriscia, Tifanie; Linton, Olivia; Lundeen, Scott G.; Sui, Zhihua published an article.Recommanded Product: 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives. And the article contained the following:

The synthesis and in vivo SAR of 5,6-dichloro-benzimidazole derivatives as novel selective androgen receptor antagonists were described. During screening of 2-alkyl benzimidazoles, it was found that a trifluoromethyl group greatly enhances antagonist activity in the prostate. Benzimidazole I was a potent AR antagonist in the rat prostate (ID50 = 0.15 mg/day). The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Recommanded Product: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to benzimidazole dichloro derivative preparation androgen receptor antagonist sar, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Recommanded Product: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 13, 2006, Ng, Raymond; Sui, Zhihua; Guan, Jihua; Lanter, James C.; Alford, Vernon C., Jr. published a patent.Electric Literature of 882978-62-3 The title of the patent was Preparation of benzimidazole derivatives as selective androgen receptor modulators. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 = H, alkyl, CH2-aryl, alkyl-OH, etc.; R2, R3 = independently H, halo, (halo)alkyl, etc.; n = 0 or 1; R4 = H, (halo)alkyl or OCOR8; R8 = (cyclo)alkyl, (hetero)aryl, aralkyl, etc.; R5 = H, halo or (halo)alkyl; R6 = (halo)alkyl, alkyl-OH, CH2-aryl, etc.; and pharmaceutically acceptable salts thereof] were prepared as selective androgen receptor modulators (SARMS). For example, oxidation of 2-(5,6-dichloro-1-ethyl-1H-benzimidazol-2-yl)-1-ethanesulfanylpropan-2-ol by mCPBA gave II. II showed activity in ventral prostate and seminal vesicle weight in vivo assay and ventral prostate and levator ani weight in vivo assay. Thus, I and their pharmaceutical compositions are useful for the treatment of disorders and conditions modulated by the androgen receptor. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Electric Literature of 882978-62-3

The Article related to benzimidazole preparation selective androgen receptor modulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 882978-62-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 13, 2006, Ng, Raymond; Sui, Zhihua; Guan, Jihua; Lanter, James C.; Alford, Vernon C., Jr. published a patent.COA of Formula: C8H6F3N3 The title of the patent was Preparation of benzimidazole derivatives as selective androgen receptor modulators. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 = H, alkyl, CH2-aryl, alkyl-OH, etc.; R2 = H, halo, (halo)alkyl, etc.; n = 0 or 1; R10 = H, halo, (halo)alkyl or OCOR8; R8 = (cyclo)alkyl, (hetero)aryl, aralkyl, etc.; R11 = H or halo; or R10and R11 are taken together with the carbon atom to which they are bound to form CO, C=N(OH) or C=N(O-alkyl); R12 = (halo)alkyl, alkyl-OH, CH2-aryl, etc.; and pharmaceutically acceptable salts thereof] were prepared as selective androgen receptor modulators (SARMS). For example, oxidation of 2-(5,6-dichloro-1-ethyl-1H-benzimidazol-2-yl)-1-ethanesulfanylpropan-2-ol by mCPBA gave II. II showed activity in ventral prostate and seminal vesicle weight in vivo assay and ventral prostate and levator ani weight in vivo assay. Thus, I and their pharmaceutical compositions are useful for the treatment of disorders and conditions modulated by the androgen receptor. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).COA of Formula: C8H6F3N3

The Article related to benzimidazole preparation selective androgen receptor modulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.COA of Formula: C8H6F3N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 26, 2018, Lee, Jennifer; Burnette, Pearlie; Chellappan, Srikumar; Barczak, Nicholas; Conti, Chiara; Escobedo, Jaime A.; Han, Bingsong; Lancia, David R., Jr.; Liu, Cuixian; Martin, Matthew W.; Ng, Pui Yee; Rudnitskaya, Aleksandra; Thomason, Jennifer R.; Zheng, Xiaozhang published a patent.Synthetic Route of 882978-62-3 The title of the patent was Methods using histone deacetylase 11 (HDAC11) inhibitors for treating proliferative diseases. And the patent contained the following:

The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Synthetic Route of 882978-62-3

The Article related to hdac11 inhibitor cell proliferative disorder treatment, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Synthetic Route of 882978-62-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 11, 2020, Fu, Bang; Li, Yinlong; Ren, Wei; Chen, Jie; Liu, Xiangyong; Wang, Jiabing; Ding, Lieming published a patent.Recommanded Product: 882978-62-3 The title of the patent was Preparation of substituted pyrazolopyrimidines as tyrosine kinase inhibitors, compositions and methods thereof. And the patent contained the following:

The invention relates to compounds of formula I and isomerides, stereoisomers, tautomers, pharmaceutically acceptable salts, prodrugs, chelates, non-covalent complexes, and solvates thereof, methods of using the compounds as Trk inhibitors, and pharmaceutical compositions comprising such compds; their preparation and use in treating cancer. Compounds of formula I, wherein ring A is C5-6 heterocyclyl; ring B is 5-membered aromatic heterocyclyl; X and Z are independently C, N, O, and S; Y is C and N;R1 is absent, H, and C1-8 alkyl; R2 is H, C1-4 alkyl-NH2, C0-4 alkyl-OH, etc.; R3 absent, C3-10 heterocyclyl; R2 and R3 can be taken together to form 5- to 6-membered carbocyclyl, heterocyclyl, aryl, etc.; R4 is (un)substituted 5- to 6-membered heteroaryl, and isomerides, stereoisomers, tautomers, pharmaceutically acceptable salts, prodrugs, chelates, non-covalent complexes, and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their tyrosine kinase inhibitory activity (some data given). The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Recommanded Product: 882978-62-3

The Article related to substituted pyrazolopyrimidine tyrosine kinase inhibitor preparation treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 882978-62-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Xuqing; Ng, Raymond; Lanter, James; Sui, Zhihua published an article in 2007, the title of the article was Synthesis of novel pyrazolines via 1,3-dipolar cycloadditions of heterocyclic isopropenes.Name: 4,5-Diamino-2-(trifluoromethyl)benzonitrile And the article contains the following content:

An efficient and practical synthesis of novel pyrazoline structures was achieved through 1,3-dipolar cycloaddition of the corresponding heterocyclic isopropenes and diazo precursors. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Name: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to heterocyclic isopropene preparation dipolar cycloaddition diazo compound, pyrazoline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2009, Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua published an article.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was An efficient synthetic process for scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine. And the article contained the following:

Starting from 4-amino-2-(trifluoromethyl)benzonitrile, an efficient and nonchromatog. process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)benzonitrile in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline that afforded 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine in 81% overall yield and 99% HPLC area% purity. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to fluoromethyldiaminobenzonitrile production, bromotrifluoromethylbenzenediamine production, amination aniline fluoromethyl derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2009, Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua published an article.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was An efficient synthetic process for scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine. And the article contained the following:

Starting from 4-amino-2-(trifluoromethyl)benzonitrile, an efficient and nonchromatog. process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)benzonitrile in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline that afforded 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine in 81% overall yield and 99% HPLC area% purity. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to fluoromethyldiaminobenzonitrile production, bromotrifluoromethylbenzenediamine production, amination aniline fluoromethyl derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts