Category: 875664-25-8

Application of 875664-25-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 875664-25-8 as follows.

Dissolve intermediate M1 (63 g, 229 mmol) in EtOH (500 mL), NaOH (27g, 689mmol) was added, and the mixture was heated to 100 C under reflux for 5h under the protection of nitrogen. TLC monitored the reaction to completion. After cooling down, a solid was obtained by filtration and the pH was adjusted to 1 with hydrochloric acid (1N). The aqueous phase was extracted with DCM. DCM was dried over anhydrous sodium sulfate, and concentrated to give 60 g of a light yellow solid, sonicate with n-hexane (10 mL) for 5 minutes. Filtration gave 43 g of white solid product M2

According to the analysis of related databases, 875664-25-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gao Wenzheng; Du Qian; Zhang Chunyu; Ren Xueyan; (40 pag.)CN110407822; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 875664-25-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 875664-25-8, name is 4-Bromo-2-phenoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Compound 5c (35.3 g, 129 mmol) was added to 130 mL EtOH, followed by the addition of 340 ml_ of 20% aqueous NaOH. The reaction was heated to reflux for 20 h. At that time the mixture was cooled to room temperature and poured into 6 N HCI. The solid was collected by vacuum filtration, dissolved in 3:1 THF-ethyl ether, and washed with brine. The organic phase was dried (MgSO4) and concentrated. The solids were dried in a vacuum oven at 60C overnight to give the desired compound 1b. MS m/z (MH+) 292.

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-phenoxybenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/30089; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts