Synthetic Route of 874472-98-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 874472-98-7 as follows.
To prepare compound 109, first 2-Methoxy-3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzonitrile was prepared by combining 3-bromo-2-cyanobenzonitrile (1.0 g), P(cyclohexyl)2biphenyl (200 mg), Pd2dbas (132 mg) and flushing with nitrogen. Then dioxane (32 mL), triethylamine (2.7 mL) and pinacolborane (1.5 mL) was added and the mixture heated at reflux. After 16 h, the reaction was quenched with saturated ammonium chloride, and extracted with EtOAc. The organic layers were washed with brine, dried over magnesium sulfate, an filtered. Flash chromatography (80% dichloromethane/hexanes) affords 2-methoxy-3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzonitrile (416 nig)
According to the analysis of related databases, 874472-98-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LIGAND PHARMACEUTICALS, INC.; WO2006/10142; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts