Category: 87376-25-8

Application of 87376-25-8, These common heterocyclic compound, 87376-25-8, name is 2-Amino-4-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a typical procedure, 5-aryl-1H-tetrazoles (1-24) were synthesized by adding aryl nitriles (1 eq.), sodium azide (1.2 eq.), and ammonium chloride (1 eq.) in solvent, the mixture was refluxed for 24 h. Progress of the reaction was monitored by thin layer chromatography. After completion of the reaction, 2.5 mL of 2M NaOH was added and the solution was stirred for half an hour. The reaction mixture was concentrated on reduced pressure, and dissolved in water. 3M HCl was added to the reaction mixture until precipitates formed. The precipitates were filtered and washed with distilled water. The yields of title compounds were found to be moderate to high.

Statistics shows that 2-Amino-4-nitrobenzonitrile is playing an increasingly important role. we look forward to future research findings about 87376-25-8.

Reference:
Article; Fatima, Itrat; Zafar, Humaira; Khan, Khalid Mohammed; Saad, Syed Muhammad; Javaid, Sumaira; Perveen, Shahnaz; Choudhary, M. Iqbal; Bioorganic Chemistry; vol. 79; (2018); p. 201 – 211;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 87376-25-8, name is 2-Amino-4-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87376-25-8, Product Details of 87376-25-8

General procedure: A mixture of 2-aminobenzonitrile 1a (0.3 mmol), trans-beta-nitrostyrene 2a (0.3 mmol), and CuBr (0.03mmol) in DMSO (2 mL) was stirred at 120 C for 8 hours till almost completed conversion of thesubstrates by TLC analysis. Then 30% NaCl solution (50 mL) was added to the mixture, which was thenextracted with EtOAc three times (3×50 mL). The extract was dried over anhydrous Na2SO4 andconcentrated in vacuo. The crude product was purified by column chromatography on silica gel (eluent:petroleumether/EtOAc) to afford the product 3a (70.8 mg, 89%) as a yellow solid.

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Reference:
Article; Cai, Qun; Chen, Hui; Liao, Meng; Liu, Yi; Peng, Na; Sheng, Hui-Yang; Yang, Mian; Chemistry Letters; vol. 49; 5; (2020); p. 526 – 529;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 87376-25-8, The chemical industry reduces the impact on the environment during synthesis 87376-25-8, name is 2-Amino-4-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.

Step 1. 2-(Ethoxycarbonylamino)-4-nitrobenzonitrile The title compound was prepared according to the procedure described in step 1 of Example 1 (Method B) from 2-amino-4-nitrobenzonitrile. tlc: Rf=0.45 (33% ethyl acetate in hexanes)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc.; US6300363; (2001); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts