Category: 873-32-5

Synthetic Route of 873-32-5, A common heterocyclic compound, 873-32-5, name is 2-Chlorobenzonitrile, molecular formula is C7H4ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried reaction tube was charged with Ni(MOTPP)2(1-naphthyl)Cl (2mol%, relative to aryl chloride), K3PO4 (3 equiv., relative to aryl chloride), and phenylboronic acid (1.5 equiv., relative to aryl chloride). Solid aryl chlorides (0.5mmol) were also added at this time. The tube was evacuated and purged with nitrogen for three times. 1,4-dioxane (2mL) and degassed water (0.2mL) were added via syringe. Liquid aryl chlorides were also added via syringe with the solvents. The mixture was stirred at 100C for 1h under a nitrogen atmosphere, and then cooled to room temperature. The reaction mixture was extracted with ethyl acetate, and the organic layers were dried over anhydrous Na2SO4. The organic phase was evaporated under reduced pressure, and the residue was purified by column chromatography on silica gel with hexane/ethylacetate as the eluent to afford the desired product. The products were identified by gas chromatography and NMR spectra.

The synthetic route of 873-32-5 has been constantly updated, and we look forward to future research findings.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 873-32-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873-32-5, name is 2-Chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Aryl chloride (1.0 mmol), phenylboronic acid (1.5 mmol),PdPAN-Ad-0.5 catalyst (13.7 mg, 0.075 mol% Pd), K2CO3(280.5 mg, 2.0 mmol) and i-PrOH/water (2.0 mL, 1:1 volumeratio) were added to a 20-mL pressure tube under argon. After the tube was heated at 100 C for 18 h with stirring in an oilbath, the reaction mixture was cooled to room temperature.The crude product was purified by column chromatography onsilica gel and analysed by 1H NMR spectroscopy to confirm the product.

The chemical industry reduces the impact on the environment during synthesis 2-Chlorobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 873-32-5, A common heterocyclic compound, 873-32-5, name is 2-Chlorobenzonitrile, molecular formula is C7H4ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 50-mL Schlenk tube was charged with aryl halide (1.63 mmol), aryl boronic acid (2.61 mmol), KOH (3.26 mmol), complex 17d (0.5 mol %), TBAB (0.5 mol % relative to the aryl halide) and water (2 mL). The sealed mixture was stirred at 120 C until TLC analysis confirmed completion of the reaction (for GC analysis the products were extracted with toluene). The aqueous solution was then extracted with ethyl acetate (3 10 mL). The combined organic phases were dried over MgSO4, filtered and evaporated in vacuo. The residue product was purified by column chromatography on silica gel using a mixture of hexane and ethyl acetate as eluent to yield biaryls 23a-m:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 873-32-5,Some common heterocyclic compound, 873-32-5, name is 2-Chlorobenzonitrile, molecular formula is C7H4ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Typically, an aryl chloride (2.0 mmol), phenylboronic acid (3.0 mmol), Pd(at)NPad2-1.0 catalyst (5.4 mg, 0.02 mol% Pd), K2CO3 (552.8 mg, 4.0 mmol) and 4.0 mL of i-PrOH/water (1:1) were added into a 25 mL pressure tube under Ar. The reaction mixture was stirred at 100 C for 18 h in an oil bath. After the reaction mixture cooled down to room temperature, the product was isolated by column with silica gel and analyzed by 1H NMR.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chlorobenzonitrile, its application will become more common.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

873-32-5, A common heterocyclic compound, 873-32-5, name is 2-Chlorobenzonitrile, molecular formula is C7H4ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (0159) Pd precatalyst (0160) Base, solvent, (0161) temperature (0162) [0043] In a flask (e.g. 25 mL tube flask) equipped with a stir bar anda nitrogen pad was added an aryl halide (e.g. 1.0 mmol), an arylboronic acid (e.g. 1.1 mmol, 1.1 equiv.), octadecanol (internal standard, e.g. 0.50 mmol, 0. 50 equiv.), an organic solvent (e.g. 5 mL), water (e.g. 1 mL), and a base (e.g. 2.2 mmol, 2.20 equiv.). The mixture was purged with nitrogen (e.g. for 10 min), then a palladacycle precatalyst (e.g. 1 – 3 mol%) was added and the resulting mixture was stirred under nitrogen at the temperature indicated in the table below until the reaction was deemed complete by H NMR analysis. Aliquots (-0.05 mL) were immediately diluted with CDCb and analyzed by H NMR spectroscopy to determine the conversion and yield (yield was determined against the internal standard, (0163) octadecanol). Table 1 shows data for Suzuki couplings conducted according to the scheme above using the stated precatalysts. Entries 6, 8, and 9 are comparative. Tables 2 and 3 show data for Suzuki couplings conducted according to the scheme above using precatalyst 3.

The synthetic route of 873-32-5 has been constantly updated, and we look forward to future research findings.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts