Category: 87150-13-8

Yu, Tian-Yang published the artcileDirect C2-Heteroarylation of Indoles by Rhodium-Catalyzed C-C Bond Cleavage of Secondary Alcohols, COA of Formula: C10H6N2O, the main research area is biheteroaryl preparation; indole secondary alc heteroarylation carbon bond cleavage rhodium catalyst.

A rhodium-catalyzed direct heteroarylation of indoles by cleavage of an inert C-C bond of alcs. is reported. This catalytic system exhibits high reactivity and tolerates various functional groups. This reaction provides a tool for the rapid construction of biheteroaryls without pre-activation of the starting materials. Control experiments were conducted to determine a possible mechanism. This reaction makes a significant contribution to the field of C-C bond activation of alcs.

Asian Journal of Organic Chemistry published new progress about C-C bond activation. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, COA of Formula: C10H6N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kulkarni, Bheemashankar A. published the artcileA solid-phase equivalent of van Leusen’s TosMIC, and its application in oxazole synthesis, Application of 4-(5-Oxazolyl)benzonitrile, the main research area is solid phase synthesis aryloxazole; oxazole aryl solid phase synthesis.

Polystyrene-SH resin, prepared from Merrifield resin in two steps, was converted to polystyrene-SO2-CH2-NC in three steps. This resin functions as a solid-phase equivalent of p-tolylsulfonylmethyl isocyanide (TosMIC). Thus, reaction with aromatic aldehydes and tetrabutylammonium hydroxide as base yields 5-aryloxazoles.

Tetrahedron Letters published new progress about Solid phase synthesis. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Application of 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Bryan published the artcileSyntheses of 4,5-Disubstituted Oxazoles via Regioselective C-4 Bromination, Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is regioselective bromination oxazole derivative; Suzuki coupling bromooxazole phenylboronic acid; aryloxazole preparation; triethylamine removal iron palladium Suzuki coupling reaction.

A scaleable and highly regioselective C-4 bromination of 5-substituted oxazoles is described. The use of DMF as solvent played a critical role in significantly improving the C-4/C-2 bromination ratio. The resulting 4-bromooxazoles were shown to be good Suzuki-Miyaura coupling partners with arylboronic acids. Furthermore, a simple and convenient method that employs triethylamine efficiently purged residual levels of palladium and iron to less than 10 ppm.

Organic Process Research & Development published new progress about Bromination, regioselective. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Bryan published the artcileRegioselective C-4 bromination of oxazoles: 4-bromo-5-(thiophen-2-yl)oxazole, Quality Control of 87150-13-8, the main research area is regioselective bromination oxazole; Suzuki Miyaura coupling brominated oxazole.

A highly regioselective bromination at C-4 of 5-substituted oxazoles is described. The use of DMF as solvent and aging of the lithiated oxazole are critical to drive the equilibrium in favor of the acyclic isonitrile enolate, resulting in significantly improved C-4/C-2 regioselectivity. These 4-bromooxazoles were shown to be good Suzuki-Miyaura coupling partners with arylboronic acids.

Organic Syntheses published new progress about Bromination, regioselective. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Quality Control of 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mukku, Narasimharao published the artcileA Facile Microwave-Assisted Synthesis of Oxazoles and Diastereoselective Oxazolines Using Aryl-Aldehydes, p-Toluenesulfonylmethyl Isocyanide under Controlled Basic Conditions, Name: 4-(5-Oxazolyl)benzonitrile, the main research area is aldehyde toluenesulfonylmethyl isocyanide cycloaddition microwave; oxazole oxazoline preparation.

In this study, a highly efficient two-component [3+2] cycloaddition reaction of substituted aryl aldehydes with 4-toluenesulfonylmethyl isocyanide (TosMIC) in the presence of 2 equiv of potassium phosphate as a base to 5-substituted oxazoles were established in a isopropanol medium under microwave irradiation However, using 1 equiv of K3PO4 as a base resulted in the diastereoselective synthesis of 4,5-disubstituted oxazolines under identical reaction conditions. The foremost benefits of these protocols are the moderate-to-excellent yields with good functional group compatibility, simple exptl. procedure, inexpensive readily available starting materials, nonchromatog. purification, and high bond-forming efficiency. The synthetic manipulation reported herein represents a cleaner route to the sustainable preparation of 5-substituted oxazoles and diastereoselective 4,5-disubstituted oxazolines derivatives

ACS Omega published new progress about [3+2] Cycloaddition reaction. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Name: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Sheng-Qing published the artcileDirect and Regioselective C-H Oxidative Difluoromethylation of Heteroarenes, Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is difluoromethyl heterocycle preparation; heteroarene regioselective oxidative difluoromethylation.

The difluoromethyl group (CF2H) is of great interest in the area of medicinal chem. However, the investigation of mol. scaffolds containing this group has been hampered by the limitation of synthetic methods for the introduction of CF2H into heteroarenes. Herein we disclose a new strategy for the direct introduction of a difluoromethyl group into heteroarenes via the copper-mediated C-H oxidative difluoromethylation of heteroarenes with TMSCF2H. This mild and regioselective method enables the convenient synthesis of a range of difluoromethylated heteroarenes in high yields. The usage of 9,10-phenanthrenequinone (PQ) as an oxidant is critical to the success of this new difluoromethylation reaction.

Journal of the American Chemical Society published new progress about Fluoromethylation (oxidative). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Ban Chin published the artcileNitrogen-15 NMR spectroscopy. Part X. Nitrogen-15 NMR spectra of azoles with two heteroatoms, SDS of cas: 87150-13-8, the main research area is heterocyclic azole nitrogen NMR; tautomerism ring chain oxazolidine.

The 15N-NMR spectra of azoles, with natural isotope abundance, have been measured under different exptl. conditions, and chem. shifts are reported for imidazoles, pyrazoles, oxazoles, isoxazoles, thiazoles, and isothiazoles. General trends of substituent effects in this heterocyclic series are discussed based on the data of 67 substituted azoles, dihydro- and tetrahydroazoles. 15N, 1H spin-coupling constants have been determined from spectra obtained by [1H] → 15N polarization-transfer experiments, i.e. an application of INEPT and DEPT pulse sequences. Two-bond and three-bond coupling constants are fully assigned and are discussed in terms of the specific pathways in azoles. The potential of structural applications of the new data is illustrated for isomeric nitro-imidazoles and highly-substituted pyrazoles, and in the case of ring-chain tautomerism of 2-substituted tetrahydrooxazoles.

Helvetica Chimica Acta published new progress about Heterocyclic compounds, nitrogen Role: PRP (Properties). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, SDS of cas: 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nishino, Mayuko published the artcileCopper-Mediated and Copper-Catalyzed Cross-Coupling of Indoles and 1,3-Azoles: Double C-H Activation, Formula: C10H6N2O, the main research area is copper catalyst cross coupling indole azole.

Copper-mediated intermol. cross-coupling of indoles and 1,3-azoles occurred with chelation assistance of a 2-pyrimidyl group. A catalytic variant has been achieved by using atm. O2 as the sole oxidant. E.g., in presence of 20 mol% Cu(OAc)2 and AcOH, reaction of N-(2-pyrimidyl)indole and benzoxazole in air gave 59% I. The cross-coupling occurs exclusively at the indole C2-postion. The 2-pyrimidyl group may be removed by treatment with NaOMe in DMSO.

Angewandte Chemie, International Edition published new progress about Azoles Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Formula: C10H6N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Odani, Riko published the artcileCopper-Mediated Dehydrogenative Biaryl Coupling of Naphthylamines and 1,3-Azoles, SDS of cas: 87150-13-8, the main research area is dehydrogenative regioselective cross coupling naphthylamine azole picolinamide directing group; copper catalyst dehydrogenative regioselective cross coupling naphthylamine azole.

A copper-mediated dehydrogenative biaryl cross-coupling of naphthylamines and 1,3-azoles has been developed. The key to its success is the introduction of an N,N-bidentate coordination system based on the picolinamide directing group. The reaction proceeds smoothly without precious transition metal catalysts and provides highly π-extended heterobiaryls directly. E.g., in presence of Cu(OAc)2 and pivalic acid in mesitylene, dehydrogenative cross-coupling of N-(2-pyridylcarbonyl)-substituted 2-naphthylamine (I) with benzoxazole gave 73% II.

Journal of Organic Chemistry published new progress about Azoles Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, SDS of cas: 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Alzieu, Thibaut published the artcileConverting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis, Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is imidazole preparation; oxazole amine microwave assisted reaction.

We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidazolyl esters.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts