September 18, 2021 News Simple exploration of 868-54-2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 868-54-2

General procedure: In a 25 mL round bottom flask, a mixture of 2,3-dihydroxynaphthalene (1 mmol),aldehyde (1 mmol), malononitrile (1 mmol) or 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1 mmol) and guanidine hydrochloride (10 mol%) were taken, and the mixture was stirred at 100C in an oil bath for an appropriate amount of time as indicated in Tables 3 and 4. The progress of the reaction was monitored by thin-layerchromatography (TLC). After completion, the reaction mixture was cooled to room temperature and CH3CN (5 mL) was added, and then a precipitate was allowed to form. The precipitate was filtered, washed with CH3CN and dried. The crude product was stirred for 5 min in boiling EtOH,and the resulting precipitate was filtered. The product 4 and 9 thus obtained was found to be pure upon 1H and 13CNMR, mass spectra, elemental analyses, and TLC examination.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Olyaei, Abolfazl; Shahsavari, Mohammad Sadegh; Sadeghpour, Mahdieh; Research on Chemical Intermediates; vol. 44; 2; (2018); p. 943 – 956;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

15-Sep-21 News Discovery of 868-54-2

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H4N4

General procedure: Heterocyclic ketene aminals (1 mmol), aryl aldehydes (1.2 mmol), malononitriledimer (1.5 mmol), acetic acid (1 mmol), piperidine (1 mmol) and ethanol (10 mL)were stirred at refluxing for 1 h. After completion of the reaction (confirmed by TLC),the reaction mixture was filtered to afford the crude product, which was furtherwashed with 95% ethanol to give pure product 4.

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sun, Feilong; Zhu, Fengjuan; Shao, Xusheng; Li, Zhong; Synlett; vol. 26; 16; (2015); p. 2306 – 2312;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

September 9,2021 News Application of 868-54-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, its application will become more common.

Synthetic Route of 868-54-2,Some common heterocyclic compound, 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, molecular formula is C6H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Heterocyclic ketene aminals (1 mmol), aryl aldehydes (1.2 mmol), malononitriledimer (1.5 mmol), acetic acid (1 mmol), piperidine (1 mmol) and ethanol (10 mL)were stirred at refluxing for 1 h. After completion of the reaction (confirmed by TLC),the reaction mixture was filtered to afford the crude product, which was furtherwashed with 95% ethanol to give pure product 4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, its application will become more common.

Reference:
Article; Sun, Feilong; Zhu, Fengjuan; Shao, Xusheng; Li, Zhong; Synlett; vol. 26; 16; (2015); p. 2306 – 2312;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 868-54-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 868-54-2.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H4N4

General procedure: A mixture of aliphatic aldehyde (10 mmol), malononitriledimer (10 mmol) and piperidine acetate (1 mmol) in i-PrOH (10 mL) washeated at reflux temperature with vigorous stirring for 20 min. After cooling,cold H2O (20 mL) was added, and the resulting precipitate was filtered, washedwith H2O and then recrystallized from a mixture of H2O/i-PrOH. Mp 267-268 C (dec.); 1H NMR (500.13 MHz, DMSO-d6): d0.87 (6H, t, J = 7.5 Hz, 2CH3), 1.36-1.45 (2H, m, CH2), 1.53-1.61 (2H, m, CH2),2.37-2.44 (1H, m, CH), 7.12 (1H, d, J = 10.8 Hz, CH), 8.91 (1H, s, NH2), 9.09 (1H,s, NH2). IR (mineral oil, cm1): 3327, 3181 (NH2), 2222, 2209 (CN). MS (EI,70 eV): m/z (%) 214 [M]+ (18), 199 [M15]+ (25), 185 [M29]+ (39). Anal. Calcdfor C12H14N4: C, 67.27; H, 6.59; N, 26.15. Found: C, 67.34; H, 6.77; N, 25.89

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 868-54-2.

Reference:
Article; Bardasov, Ivan N.; Alekseeva, Anastasiya U.; Mihailov, Denis L.; Ershov, Oleg V.; Grishanov, Dmitry A.; Tetrahedron Letters; vol. 56; 14; (2015); p. 1830 – 1832;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Extracurricular laboratory: Synthetic route of 868-54-2

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Aminoprop-1-ene-1,1,3-tricarbonitrile

General procedure: mmol), malononitrile dimer (1.5 mmol), AcOH (1 mmol), piperidine(1 mmol), and EtOH (10 mL) were stirred at refluxing for1 h. After completion of the reaction (confirmed by TLC), thereaction mixture was filtered to afford the crude product, whichwas further washed with 95% EtOH to give pure product 4. Thestructures of the products were well characterized by NMR andHRMS studies. The characterization data of representative compound 4a. Compound 4a: light yellow solid; mp 300.9-302.0 C. 1H NMR(400 MHz, DMSO-d6): delta = 9.33 (s, 1 H), 7.37 (d, J = 7.6 Hz, 2 H),7.25 (d, J = 7.6 Hz, 2 H), 6.41 (s, 2 H), 6.24 (s, 2 H), 5.40 (s, 1 H),4.08 (t, 2 H), 3.89-3.73 (m, 2 H) ppm. 13C NMR (100 MHz,DMSO-d6): delta = 159.8, 154.2, 152.4, 149.1, 142.5, 130.9, 129.7,127.6, 116.6, 106.6, 92.6, 69.9, 44.4, 43.3, 36.6 ppm. ESI-HRMS:m/z calcd for C17H1435ClN7O2 [M – H]-: 382.0898; found:382.0811; calcd for C17H1437ClN7O2 [M – H]-: 384.0898; found:384.0771

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sun, Feilong; Zhu, Fengjuan; Shao, Xusheng; Li, Zhong; Synlett; vol. 26; 16; (2015); p. 2306 – 2312;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some tips on 868-54-2

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 868-54-2,Some common heterocyclic compound, 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, molecular formula is C6H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 20 mL reaction vial, 4-hydroxycarbazole 1{1} (0.183g, 1mmol) with benzaldehyde 2{1} (0.106g, 1mmol), and 2-aminoprop-1-ene-1,1,3-tricarbonitrile 3 (0.132g, 1mmol) and ethanol (3 mL), as well as EtONa (0.064g, 1mmol)were mixed and then capped (the automatic mode stirring helped the mixing and uniform heating of the reactants). The mixture was heated for 15 min at 80 C under microwave irradiation. Upon completion, confirmed by TLC, the reaction mixture was cooled to room temperature. The crystalline solid product was collected by Buchner filtration, subsequently washed with two different solvents of ethanol and ethylether in sequence to give the pure product 4{1,1}.

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Wenhui; Wang, Jianqiang; Mao, Jingpeng; Hu, Li; Wu, Xiaohua; Guo, Cheng; Tetrahedron Letters; vol. 57; 18; (2016); p. 1985 – 1989;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Extended knowledge of 868-54-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 868-54-2, its application will become more common.

Some common heterocyclic compound, 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, molecular formula is C6H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H4N4

General procedure: A solution of 0.264 g (2 mmol) of2-aminoprop-1-ene-1,1,3-tricarbonitrile and 0.088 g(2 mmol) of freshly distilled acetaldehyde in 5 mL of1,4-dioxane containing a catalytic amount of piperidiniumacetate was stirred for 2 h at 60C. A solution of0.320 g (2 mmol) of bromine in a mixture of 1 mL ofconcentrated aqueous HBr and 2 mL of 1,4-dioxanewas then added, and the mixture was stirred for 4 hat 70C. When the reaction was complete (TLC), themixture was cooled, neutralized to pH 7 witha 5% aqueous solution of sodium carbonate, anddiluted with 20 mL of water. A tarry material separatedand was ground in water until a solid precipitate wasobtained. It was filtered off, washed with a smallamount of isopropyl alcohol and distilled water, and recrystallized from ethyl acetate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 868-54-2, its application will become more common.

Reference:
Article; Bardasov; Alekseeva, A. Yu.; Ershov; Russian Journal of Organic Chemistry; vol. 54; 7; (2018); p. 1106 – 1108; Zh. Org. Khim.; vol. 54; 7; (2018); p. 1098 – 1099,2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some scientific research about 868-54-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, its application will become more common.

Synthetic Route of 868-54-2,Some common heterocyclic compound, 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, molecular formula is C6H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 0.085 g (1 mmol) of piperidine, 0.182 g (1 mmol) of enaminoketone 2, 0.132 g (1 mmol) of 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and 0.106 g (1 mmol) of benzaldehyde in 5 mL of ethanol was stirred at 30-40 for 30 min. On the completion of the reaction (TLC monitoring) the mixture was cooled, the separated precipitate was filtered off, washed with a little 2-propanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, its application will become more common.

Reference:
Article; Alekseeva, A. Yu.; Bardasov; Mikhailov; Ershov; Russian Journal of Organic Chemistry; vol. 53; 8; (2017); p. 1243 – 1248; Zh. Org. Khim.; vol. 53; 8; (2017); p. 1227 – 1232,6;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Simple exploration of 2-Aminoprop-1-ene-1,1,3-tricarbonitrile

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C6H4N4

General procedure: In a 25 mL round bottom flask, a mixture of 2,3-dihydroxynaphthalene (1 mmol),aldehyde (1 mmol), malononitrile (1 mmol) or 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1 mmol) and guanidine hydrochloride (10 mol%) were taken, and the mixture was stirred at 100C in an oil bath for an appropriate amount of time as indicated in Tables 3 and 4. The progress of the reaction was monitored by thin-layerchromatography (TLC). After completion, the reaction mixture was cooled to room temperature and CH3CN (5 mL) was added, and then a precipitate was allowed to form. The precipitate was filtered, washed with CH3CN and dried. The crude product was stirred for 5 min in boiling EtOH,and the resulting precipitate was filtered. The product 4 and 9 thus obtained was found to be pure upon 1H and 13CNMR, mass spectra, elemental analyses, and TLC examination.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Olyaei, Abolfazl; Shahsavari, Mohammad Sadegh; Sadeghpour, Mahdieh; Research on Chemical Intermediates; vol. 44; 2; (2018); p. 943 – 956;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Simple exploration of 2-Aminoprop-1-ene-1,1,3-tricarbonitrile

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 868-54-2, Formula: C6H4N4

General procedure: A mixture of 0.085 g (1 mmol) of piperidine, 0.182 g (1 mmol) of enaminoketone 2, 0.132 g (1 mmol) of 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and 0.106 g (1 mmol) of benzaldehyde in 5 mL of ethanol was stirred at 30-40 for 30 min. On the completion of the reaction (TLC monitoring) the mixture was cooled, the separated precipitate was filtered off, washed with a little 2-propanol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Alekseeva, A. Yu.; Bardasov; Mikhailov; Ershov; Russian Journal of Organic Chemistry; vol. 53; 8; (2017); p. 1243 – 1248; Zh. Org. Khim.; vol. 53; 8; (2017); p. 1227 – 1232,6;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts